-
作者：Ke, Fang; Benet, Zachary L.; Shelyakin, Pavel; V. Britanova, Olga; Gupta, Neetu; Dent, Alexander L.; Moore, Bethany B.; Grigorova, Irina L.
作者单位：Pirogov Russian National Research Medical University; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences; University of Kiel; Cleveland Clinic Foundation; Indiana University System; Indiana University Bloomington
摘要：Follicular regulatory T cells (Tfr) can play opposite roles in the regulation of germinal center (GC) responses. Depending on the studies, Tfr suppress or support GC and B cell affinity maturation. However, which factors determine positive vs. negative effects of Tfr on the GC B cell is unclear. In this study, we show that GC centrocytes that express MYC up- regulate expression of CCL3 chemokine that is needed for both the positive and negative regulation of GC B cells by Tfr. B cell-intrinsic...
-
作者：Ahmed, A. Razzaque; Kalesinskas, Mikole; Kaveri, Srini, V
作者单位：Tufts University; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite Paris Cite
摘要：Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use and therapeutic success, its mechanisms of action are not completely understood. Some of its anti- inflammatory and immunomodulatory actions have been studied. In this study, the authors present a twenty ...
-
作者：Banuelos, Allison; Zhang, Allison; Berouti, Hala; Baez, Michelle; Yilmaz, Leyla; Georgeos, Nardin; Marjon, Kristopher D.; Miyanishi, Masanori; Weissman, Irving L.
作者单位：Stanford University; Stanford University; Kobe University; Stanford University
摘要：The use of colony- stimulating factor - 1 receptor (CSF1R) inhibitors has been widely explored as a strategy for cancer immunotherapy due to their robust depletion of tumor- associated macrophages (TAMs). While CSF1R blockade effectively eliminates TAMs from the solid tumor microenvironment, its clinical efficacy is limited. Here, we use an inducible CSF1R knockout model to investigate the persistence of tumor progression in the absence of TAMs. We find increased frequencies of granulocytic my...
-
作者：Xu, Jie; Gao, Xiaoyin; Zheng, Liming; Jia, Xia; Xu, Kui; Ma, Yuwei; Wei, Xiaoding; Liu, Nan; Peng, Hailin; Wang, Hong-Wei
作者单位：Tsinghua University; Tsinghua University; Chinese Academy of Sciences; Peking University; Peking University; Beijing Graphene Institute; Peking University
摘要：High- quality specimen preparation plays a crucial role in cryo- electron microscopy (cryo-EM) structural analysis. In this study, we have developed a reliable and convenient technique called the graphene sandwich method for preparing cryo-EM specimens. This method involves using two layers of graphene films that enclose macromolecules on both sides, allowing for an appropriate ice thickness for cryo-EM analysis. The graphene sandwich helps to mitigate beam- induced charging effect and reduce ...
-
作者：Franze, Kristian
作者单位：University of Cambridge; University of Erlangen Nuremberg
-
作者：Mao, Minglei; Gong, Lei; Wang, Xiaobo; Wang, Qiyu; Zhang, Guoqun; Wang, Haoxiang; Xie, Wei; Suo, Liumin; Wang, Chengliang
作者单位：Huazhong University of Science & Technology; Chinese Academy of Sciences; Institute of Physics, CAS; Huazhong University of Science & Technology
摘要：Fluoro- substitution solvents have achieved great success in electrolyte engineering for high- energy lithium metal batteries, which, however, is beset by low solvating power, thermal and chemical instability, and possible battery swelling. Instead, we herein introduce cyanogen as the electron- withdrawing group to enhance the oxidative stability of ether solvents, in which cyanogen and ether oxygen form the chelating structure with Li+ not notably undermining the solvating power. Cyano-group ...
-
作者：Matsumoto, Ayaka; Toyoshima, Yu; Zhang, Chenqi; Isozaki, Akihiro; Goda, Keisuke; Iino, Yuichi
作者单位：University of Tokyo; University of Tokyo; Ritsumeikan University; University of California System; University of California Los Angeles; Wuhan University
摘要：Animals navigate their environment by manipulating their movements and adjusting their trajectory which requires a sophisticated integration of sensory data with their current motor status. Here, we utilize the nematode Caenorhabditis elegans to explore the neural mechanisms of processing the sensory and motor information for navigation. We developed a microfluidic device which allows animals to freely move their heads while receiving temporal NaCl stimuli. We found that C. elegans regulates n...
-
作者：Zhou, Xunzhu; Huang, Yaohui; Wen, Bo; Yang, Zhuo; Hao, Zhiqiang; Li, Lin; Chou, Shu-Lei; Li, Fujun
作者单位：Nankai University; Wenzhou University; Nankai University; Haihe Laboratory of Sustainable Chemical Transformations
摘要：High- performance sodium storage at low temperature is urgent with the increasingly stringent demand for energy storage systems. However, the aggravated capacity loss is induced by the sluggish interfacial kinetics, which originates from the interfacial Na+ desolvation. Herein, all- fluorinated anions with ultrahigh electron donicity, trifluoroacetate (TFA-), are introduced into the diglyme (G2) - based electrolyte for the anion- reinforced solvates in a wide temperature range. The unique solv...
-
作者：Hoskins, Joel R.; Wickramaratne, Anushka C.; Jewell, Connor P.; Jenkins, Lisa M.; Wickner, Sue
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
摘要：Hsp70, Hsp90, and ClpB/Hsp100 are molecular chaperones that help regulate proteostasis. Bacterial and yeast Hsp70s and their cochaperones function synergistically with Hsp90s to reactivate inactive and aggregated proteins by a mechanism that requires a direct interaction between Hsp90 and Hsp70 both in vitro and in vivo. Escherichia coli and yeast Hsp70s also collaborate in bichaperone systems with ClpB and Hsp104, respectively, to disaggregate and reactivate aggregated proteins and amyloids s...
-
作者：Lee, Seong-Kyun; Crosnier, Cecile; Valenzuela-Leon, Paola Carolina; Dizon, Brian L. P.; Atkinson, John P.; Mu, Jianbing; Wright, Gavin J.; Calvo, Eric; Gunalan, Karthigayan; Miller, Louis H.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of York - UK; University of Hull; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Washington University (WUSTL)
摘要：The discovery that Africans were resistant to infection by Plasmodium vivax (P. vivax) led to the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) interacting with the Duffy Antigen Receptor for Chemokines (DARC) expressed on erythrocytes. However, the recent reporting of P. vivax infections in DARC- negative Africans suggests that the parasite might use an alternate invasion pathway to infect DARC-negative reticulocytes. To identify the parasite ligands a...
