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作者：Hwang, Yen-Ting; Xie, Shang Ping; Chen, Po-Ju; Tseng, Hung-Yi; Deser, Clara
作者单位：National Taiwan University; University of California System; University of California San Diego; Scripps Institution of Oceanography; George Mason University; National Center Atmospheric Research (NCAR) - USA
摘要：The discrepancy between the observed lack of surface warming in the eastern equatorial Pacific and climate model projections of an El Nino- like warming pattern confronts the climate research community. While anthropogenic aerosols have been suggested as a cause, the prolonged cooling trend over the equatorial Pacific appears in conflict with Northern Hemisphere aerosol emission reduction since the 1980s. Here, using CESM, we show that the superposition of fast and slow responses to aerosol em...
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作者：Ma, Yongshuo; Shang, Yi; Stephanopoulos, Gregory
作者单位：Massachusetts Institute of Technology (MIT); Chinese Academy of Agricultural Sciences; Yunnan Normal University; Yunnan Normal University
摘要：Constructing efficient cell factories for product synthesis is frequently hampered by competing pathways and/or insufficient precursor supply. This is particularly evident in the case of triterpenoid biosynthesis in Yarrowia lipolytica, where squalene biosynthesis is tightly coupled to cytosolic biosynthesis of sterols essential for cell viability. Here, we addressed this problem by reconstructing the complete squalene biosynthetic pathway, starting from acetyl-CoA, in the peroxisome, thus har...
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作者：Lin, Liang; Li, Jiantao; Zhang, Yinggan; Zheng, Hongfei; Huang, Youzhang; Zhang, Chengkun; Sa, Baisheng; Wang, Laisen; Lin, Jie; Peng, Dong-Liang; Lu, Jun; Amine, Khalil; Xie, Qingshui
作者单位：Xiamen University; United States Department of Energy (DOE); Argonne National Laboratory; Zhejiang University; Fuzhou University; Xiamen University
摘要：High electrochemical reversibility is required for the application of high- energy- density lithium (Li) metal batteries; however, inactive Li formation and SEI (solid electrolyte interface)- instability- induced electrolyte consumption cause low Coulombic efficiency (CE). The prior interfacial chemical designs in terms of alloying kinetics have been used to enhance the CE of Li metal anode; however, the role of its redox chemistry at heterointerfaces remains a mystery. Herein, the relationshi...
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作者：Nelson, Anders R.; Christiansen, Steven L.; Naegle, Kristen M.; Saucerman, Jeffrey J.
作者单位：University of Virginia; Brigham Young University
摘要：Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti- fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high- content microscopy screen of human cardiac fibroblasts treated with 13 clinically r...
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作者：Connelly, Blair C.; Taylor, Patrick J.; de Coster, George J.
作者单位：United States Department of Defense; US Army Research, Development & Engineering Command (RDECOM); US Army Research Laboratory (ARL); United States Army
摘要：We present evidence of a strong circular photon drag effect (PDE) in topological insulators (TIs) through the observation of helicity- dependent topological photocurrents with threefold rotational symmetry using THz spectroscopy in epitaxially-grown Bi2Se3 with reduced crystallographic twinning. We establish how twinned domains introduce competing nonlinear optical (NLO) responses inherent to the crystal structure that obscure geometry- sensitive optical processes through the introduction of a...
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作者：Li, Chenglong; Luo, Hongyu; Lin, Xinyi; Zhang, Shun; Song, Jizhou
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Tsinghua University
摘要：Transfer printing that enables heterogeneous integration of materials into spatially organized, functional arrangements is essential for developing unconventional electronic systems. Here, we report a laser- driven noncontact bubble transfer printing via a hydrogel composite stamp, which features a circular reservoir filled with hydrogel inside a stamp body and encapsulated by a laser absorption layer and an adhesion layer. This composite structure of stamp provides a reversible thermal contro...
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作者：Green, Natalie A.
作者单位：New York University
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作者：Yuan, Ye; Yadlapalli, Swathi
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
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作者：Baghdasaryan, Ani; Liu, Haoran; Ren, Fuqiang; Hsu, Rusiou; Jiang, Yingying; Wang, Feifei; Zhang, Mengzhen; Grigoryan, Lilit; Dai, Hongjie
作者单位：Stanford University; Stanford University; Stanford University
摘要：Surgical resections of solid tumors guided by visual inspection of tumor margins have been performed for over a century to treat cancer. Near- infrared (NIR) fluorescence labeling/imaging of tumor in the NIR-I (800 to 900 nm) range with systemically administrated fluorophore/tumor- targeting antibody conjugates have been introduced to improve tumor margin delineation, tumor removal accuracy, and patient survival. Here, we show Au25 molecular clusters functionalized with phosphorylcholine ligan...
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作者：Leone, Stephen R.
