5期

最新文章

• The sparse macroecology of microbiology AI翻译
  作者：Kempes, Christopher P.
  作者单位：The Santa Fe Institute
• Surface- mediated spontaneous emulsification of the acylated peptide semaglutide AI翻译
  作者：Li, Qi; Tangry, Vasudev; Allen, David P.; Seibert, Kevin D.; Qian, Ken K.; Wagner, Norman J.
  作者单位：University of Delaware; Eli Lilly
  摘要：Acylated peptides composed of glucagon-like peptide- 1 receptor agonists modified with a fatty acid side chain are an important class of therapeutics for type 2 diabetes and obesity but are susceptible to an unusual physical instability in the presence of hydrophobic surfaces, i.e., spontaneous emulsification, also known as ouzo formation in practice. In this work, light scattering, small - angle X - ray scattering, and circular dichroism measurements are used to characterize the physical prop...
• Boosted hydrogen evolution kinetics of heteroatom-doped carbons with isolated Zn as an accelerant AI翻译
  作者：Li, Yang; Zuo, Shouwei; Wei, Fen; Chen, Cailing; Zhang, Guikai; Zhao, Xiaojuan; Wu, Zhipeng; Wang, Sibo; Zhou, Wei; Rueping, Magnus; Han, Yu; Zhang, Huabin
  作者单位：King Abdullah University of Science & Technology; Fuzhou University; King Abdullah University of Science & Technology; Chinese Academy of Sciences; Institute of High Energy Physics, CAS; Tianjin University
  摘要：Carbon - based single - atom catalysts, a promising candidate in electrocatalysis, offer insights into electron- donating effects of metal center on adjacent atoms. Herein, we present a practical strategy to rationally design a model catalyst with a single zinc (Zn) atom coordinated with nitrogen and sulfur atoms in a multilevel carbon matrix. The Zn site exhibits an atomic interface configuration of ZnN4S1, where Zn's electron injection effect enables thermal- neutral hydrogen adsorption on n...
• Health and equity implications of individual adaptation to air pollution in a changing climate AI翻译
  作者：Sparks, Matt S.; Farahbakhsh, Isaiah; Anand, Madhur; Bauch, Chris T.; Conlon, Kathryn C.; East, James D.; Li, Tianyuan; Lickley, Megan; Garcia-Menendez, Fernando; Monier, Erwan; Saari, Rebecca K.
  作者单位：University of Waterloo; University of Guelph; University of Waterloo; University of California System; University of California Davis; University of California System; University of California Davis; North Carolina State University; Massachusetts Institute of Technology (MIT); University of California System; University of California Davis; Harvard University; Georgetown University
  摘要：Future climate change can cause more days with poor air quality. This could trigger more alerts telling people to stay inside to protect themselves, with potential consequences for health and health equity. Here, we study the change in US air quality alerts over this century due to fine particulate matter (PM2.5), who they may affect, and how they may respond. We find air quality alerts increase by over 1 mo per year in the eastern United States by 2100 and quadruple on average. They predomina...
• Identification of KU-55933 as an anti- atherosclerosis compound by using a hemodynamic-based high- throughput drug screening platform AI翻译
  作者：Wei, Shu-Yi; Fu, Wei-Shan; Liu, Chang-Hsuan; Wang, Wei-Li; Shih, Yu-Tsung; Chien, Shu; Chiu, Jeng-Jiann
  作者单位：National Health Research Institutes - Taiwan; Taipei Medical University; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Taipei Medical University; Taipei Medical University; National Tsing Hua University
  摘要：Several compounds have been used for atherosclerosis treatment, including clinical trials; however, no anti- atherosclerotic drugs based on hemodynamic force- mediated atherogenesis have been discovered. Our previous studies demonstrated that small mothers against decapentaplegic homolog 1/5 (Smad1/5) is a convergent signaling molecule for chemical [e.g., bone morphogenetic proteins (BMPs)] and mechanical (e.g., disturbed flow) stimulations and hence may serve as a promising hemodynamic-based ...
• Computational inference of eIF4F complex function and structure in human cancers AI翻译
  作者：Wu, Su; Wagner, Gerhard
  作者单位：Harvard University; Harvard Medical School
  摘要：The canonical eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4G1, eIF4A1, and the cap- binding protein eIF4E, plays a crucial role in cap- dependent translation initiation in eukaryotic cells. An alternative cap- independent initiation can occur, involving only eIF4G1 and eIF4A1 through internal ribosome entry sites (IRESs). This mechanism is considered complementary to cap- dependent initiation, particularly in tumors under stress conditions. However, the selection and molecu...
• Essential role of MFSD1- GLMP- GIMAP5 in lymphocyte survival and liver homeostasis (VOL 120, e2314429120, 2023) AI翻译
  作者：Zhong, Xue; Moresco, James J.; Diedrich, Jolene K.; Pinto, Antonio F. M.; SoRelle, Jeffrey A.; Wang, Jianhui; Keller, Katie; Ludwig, Sara; Moresco, Eva Marie Y.; Saghatelian, Alan; Yates, John R., III; Beutler, Bruce; Choi, Jin Huk
  作者单位：Salk Institute
• A plant flavonol and genetic suppressors rescue a pathogenic mutation associated with kinesin in neurons AI翻译
  作者：Chai, Yongping; Li, Dong; Gong, Weibin; Ke, Jingyi; Tian, Dianzhe; Chen, Zhe; Guo, Angel; Guo, Zhengyang; Li, Wei; Feng, Wei; Ou, Guangshuo
  作者单位：Tsinghua University; Tsinghua University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University
  摘要：KIF1A, a microtubule- based motor protein responsible for axonal transport, is linked to a group of neurological disorders known as KIF1A- associated neurological disorder (KAND). Current therapeutic options for KAND are limited. Here, we introduced the clinically relevant KIF1A(R11Q) variant into the Caenorhabditis elegans homolog UNC- 104, resulting in uncoordinated animal behaviors. Through genetic suppressor screens, we identified intragenic mutations in UNC- 104's motor domain that rescue...
• Increased expression of SSEA-4 on TKI- resistant non-small cell lung cancer with EGFR-T790M mutation AI翻译
  作者：Chen, Nai- Yu; Lin, Chih- Wei; Lai, Ting- Yen; Wu, Chung-Yi; Liao, Pei-Chi; Hsu, Tsui-Ling; Wong, Chi-Huey
  作者单位：Academia Sinica - Taiwan; National Yang Ming Chiao Tung University; China Medical University Taiwan; China Medical University Taiwan; Scripps Research Institute
  摘要：Non-small cell lung cancer (NSCLC), a major life-threatening disease accounting for 85% of all lung cancer cases, has been treated with tyrosine kinase inhibitors (TKIs), but often resulted in drug resistance, and approximately 60% of TKI-resistant cases are due to acquired secondary (epithelial growth factor receptor) EGFR-T790M mutation. To identify alternative targets for TKI-resistant NSCLC with EGFR-T790M mutation, we found that the three globo - series glycosphingolipids are increasingly...
• Single- cell RNA sequencing unveils unique transcriptomic signatures of endothelial cells and role of ENO1 in response to disturbed flow AI翻译
  作者：Chen, Li- Jing; Li, Julie Yi- Shuan; Nguyen, Phu; He, Ming; Chen, Zhen Bouman; Subramaniam, Shankar; Shyy, John Y. - J.; Chien, Shu
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; City of Hope; Beckman Research Institute of City of Hope; University of California System; University of California San Diego
  摘要：Flow patterns exert significant effects on vascular endothelial cells (ECs) to lead to the focal nature of atherosclerosis. Using a step flow chamber to investigate the effects of disturbed shear (DS) and pulsatile shear (PS) on ECs in the same flow channel, we conducted single - cell RNA sequencing analyses to explore the distinct transcriptomic profiles regulated by DS vs. PS. Integrated analysis identified eight cell clusters and demonstrated that DS induces EC transition from atheroprotect...