5期

最新文章

• A spatiotemporal molecular atlas of the ovulating mouse ovary AI翻译
  作者：Mantri, Madhav; Zhang, Hanxue Hannah; Spanos, Emmanuel; Ren, Yi A.; De Vlaminck, Andiwijn
  作者单位：Cornell University; Cornell University
  摘要：Ovulation is essential for reproductive success, yet the underlying cellular and molecular mechanisms are far from clear. Here, we applied high- resolution spatiotemporal transcriptomics to map out cell type- and ovulation stage-specific molecular programs as function of time during follicle maturation and ovulation in mice. Our analysis revealed dynamic molecular transitions within granulosa cell types that occur in tight coordination with mesenchymal cell proliferation. We identified molecul...
• Expression of Atoh1, Gfi1, and Pou4f3 in the mature cochlea reprograms nonsensory cells into hair cells AI翻译
  作者：Mcgovern, Melissa M.; Hosamani, Ishwar, V; Niu, Yichi; Nguyen, Ken Y.; Zong, Chenghang; Groves, Andrew K.
  作者单位：Baylor College of Medicine; Baylor College of Medicine
  摘要：Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate; consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian vertebrates can regenerate hair cells from neighboring supporting cells, many humans with severe hearing loss lack both hair cells and supporting cells, with the organ of Corti being replaced by a flat epithelium of nonsensory cells. To determine whether the mature cochlea can produce hair cells in vivo, we reprogrammed nons...
• Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector) AI翻译
  作者：Swanson, Larry W.; Hahn, Joel D.; Sporns, Olaf
  作者单位：University of Southern California; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：The vertebrate spinal cord (SP) is the long, thin extension of the brain forming the central nervous system's caudal sector. Functionally, the SP directly mediates motor and somatic sensory interactions with most parts of the body except the face, and it is the preferred model for analyzing relatively simple reflex behaviors. Here, we analyze the organization of axonal connections between the 50 gray matter regions forming the bilaterally symmetric rat SP. The assembled dataset suggests that t...
• Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β- dependent metabolic shifts in osteoclastogenesis AI翻译
  作者：Zhang, Zheng; Meng, Yichen; Lin, Tao; Zhang, Zhanrong; Tao, Zhengbo; Yin, Haozan; Yang, Fu; Zhou, Xuhui
  作者单位：Naval Medical University; Naval Medical University; Shanghai Jiao Tong University
  摘要：Long non- coding RNA (lncRNA) serves as a vital regulator of bone metabolism, but its role in pathologically overactive osteoclast differentiation remains elusive. Here, we identify lncRNA Dancr (Differentiation Antagonizing Non- protein Coding RNA) as a critical suppressor of osteoclastogenesis and bone resorption, which is down- regulated in response to estrogen deficiency. Global or osteoclast- specific Dancr Knockout mice display significant trabecular bone deterioration and enhanced osteo...
• Art promotes exploration of negative content AI翻译
  作者：Ozbay, Yagmur; Stamkou, Eftychia; Oosterwijk, Suzanne
  作者单位：University of Amsterdam
  摘要：Experiencing negative content through art has a unique power to transform our percepdence is scarce, since experimental testing of art experiences poses significant challenges. Here, we aimed to fill this gap by quantifying and comparing individuals' preference for engaging with art and nonart depicting matched negative content via two behavioral measures: the choice to engage vs. avoid and the duration of engagement. Across five studies (total N = 1,063), results revealed a preference for eng...
• Recurrent viral capture of cellular phosphodiesterases that antagonize OAS- RNase L AI翻译
  作者：Goldstein, Stephen A.; Elde, Nels C.
  作者单位：Utah System of Higher Education; University of Utah; Howard Hughes Medical Institute
  摘要：Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral pathway, a key effector component of the innate immune response. Although the function of these proteins is well- characterized, the origins of these gene acquisitions are less clear. Phylogenetic analysis revealed at least five independent PDE acquisition events by ancestral viruses. We found evidence that PDE- encoding genes ...
• Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses AI翻译
  作者：Sutter, Pearl A.; Willis, Cory M.; Menoret, Antoine; Nicaise, Alexandra M.; Sacino, Anthony; Sikkema, Arend. H.; Jellison, Evan R.; Win, Kyaw K.; Han, David K.; Church, William; Baron, Wia; Vella, Anthony T.; Crocker, Stephen J.
  作者单位：University of Connecticut; University of Connecticut; University of Groningen; University of Connecticut; Trinity College; Trinity College
  摘要：Astrocyte activation is associated with neuropathology and the production of tissue inhibitor of metalloproteinase-1 (TIMP1). TIMP1 is a pleiotropic extracellular protein that functions both as a protease inhibitor and as a growth factor. Astrocytes that lack expression of Timp1 do not support rat oligodendrocyte progenitor cell (rOPC) differentiation, and adult global Timp1 knockout (Timp1KO) mice do not efficiently remyelinate following a demyelinating injury. Here, we performed an unbiased ...
• Remembering Ronald L. Phillips: Pioneer in crop biotechnology, mentor, and humanitarian AI翻译
  作者：Kaeppler, Shawn M.; Springer, Nathan
  作者单位：University of Wisconsin System; University of Wisconsin Madison; Bayer AG; Bayer CropScience; University of Minnesota System; University of Minnesota Twin Cities
• Reductions in premature deaths from heat and particulate matter air pollution in South Asia, China, and the United States under decarbonization AI翻译
  作者：Shindell, Drew; Faluvegi, Greg; Nagamoto, Emily; Parsons, Luke; Zhang, Yuqiang
  作者单位：Duke University; Columbia University; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Goddard Institute for Space Studies; Shandong University
  摘要：Following a sustainable development pathway designed to keep warming below 2 degrees C will benefit human health. We quantify premature deaths attributable to fine particulate matter (PM2.5) air pollution and heat exposures for China, South Asia, and the United States using projections from multiple climate models under high- and low-emission scenarios. Projected changes in premature deaths are typically dominated by population aging, primarily reflecting increased longevity leading to greater...
• Water striders are impervious to raindrop collision forces and submerged by collapsing craters AI翻译
  作者：Watson, Daren A.; Thornton, Mason R.; Khan, Hiba A.; Diamco, Ryan C.; Yilmaz-Aydin, Duygu; Dickerson, Andrew K.
  作者单位：Florida Polytechnic University; State University System of Florida; University of Central Florida; Malatya Turgut Ozal University; University of Tennessee System; University of Tennessee Knoxville
  摘要：Water striders are abundant in areas with high humidity and rainfall. Raindrops can weigh more than 40 times the adult water strider and some pelagic species spend their entire lives at sea, never contacting ground. Until now, researchers have not systematically investigated the survival of water striders when impacted by raindrops. In this experimental study, we use high-speed videography to film drop impacts on water striders. Drops force the insects subsurface upon direct contact. As the en...