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作者：Wang, Wenli; Kim, Junghyun; Martinez, Teresa S.; Huq, Enamul; Sung, Sibum; Baulcombe, David
作者单位：University of Texas System; University of Texas Austin
摘要：Light is a crucial environmental factor that impacts various aspects of plant development. Phytochromes, as light sensors, regulate myriads of downstream genes to mediate developmental reprogramming in response to changes in environmental conditions. CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is an E3 ligase for a number of substrates in light signaling, acting as a central repressor of photomorphogenesis. The interplay between phytochrome B (phyB) and COP1 forms an antagonistic regulatory modul...
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作者：Stokes, Leah C.; Franzblau, Emma; Lovering, Jessica R.; Miljanich, Chris
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作者：Xu, Ting; Chen, Zhiyi; Zhou, Xinqi; Wang, Lan; Zhou, Feng; Yao, Dezhong; Zhou, Bo; Becker, Benjamin
作者单位：Sichuan Provincial People's Hospital; University of Electronic Science & Technology of China; University of Electronic Science & Technology of China; Army Medical University; Southwest University - China; Southwest University - China; Sichuan Normal University; University of Hong Kong; University of Hong Kong
摘要：Accumulating evidence suggests that the brain renin angiotensin system (RAS) plays a pivotal role in the regulation of cognition and behavior as well as in the neuropathology of neurological and mental disorders. The angiotensin II type 1 receptor (AT1R) mediates most functional and neuropathology-relevant actions associated with the central RAS. However, an overarching comprehension to guide translation and utilize the therapeutic potential of the central RAS in humans is currently lacking. W...
