COP1 controls light- dependent chromatin remodeling

• 成果类型: Article
• 署名作者: Wang, Wenli; Kim, Junghyun; Martinez, Teresa S.; Huq, Enamul; Sung, Sibum; Baulcombe, David
• 署名单位: University of Texas System; University of Texas Austin
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15198
• DOI: 10.1073/pnas.2312853121
• 发表日期: 2024-02-20
• 关键词: regulated gene-expression; mediated regulation; plant-growth; arabidopsis; phytochrome; protein; photomorphogenesis; hy5; vernalization; transcription

摘要

Light is a crucial environmental factor that impacts various aspects of plant development. Phytochromes, as light sensors, regulate myriads of downstream genes to mediate developmental reprogramming in response to changes in environmental conditions. CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) is an E3 ligase for a number of substrates in light signaling, acting as a central repressor of photomorphogenesis. The interplay between phytochrome B (phyB) and COP1 forms an antagonistic regulatory module that triggers extensive gene expression reprogramming when exposed to light. Here, we uncover a role of COP1 in light- dependent chromatin remodeling through the regulation of VIL1 (VIN3- LIKE 1)/VERNALIZATION 5, a Polycomb protein. VIL1 directly interacts with phyB and regulates photomorphogenesis through the formation of repressive chromatin loops at downstream growth- promoting genes in response to light. Furthermore, we reveal that COP1 governs light- dependent formation of chromatin loop and limiting a repressive histone modification to fine- tune expressions of growth- promoting genes during photomorphogenesis through VIL1.