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作者：Kulak, Klaudia; Kuska, Katarzyna; Colineau, Lucie; Mckay, Marina; Maziarz, Karolina; Slaby, Julia; Blom, Anna M.; King, Ben C.
作者单位：Lund University
摘要：One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation, associated with altered pancreatic islet function and structure, if unresolved. IL-1 beta is a proinflammatory cytokine which detrimentally affects beta-cell function. In the course of diabetes, complement components, including the central complement protein C3, are deregulated. Previously, we reported high C3 expression in human pancreatic islets, with upregulation after IL-1 beta treatment. In the curre...
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作者：Liao, Xuelong; Chen, Shan; Chen, Jialei; Li, Youzeng; Wang, Wei; Lu, Tiantian; Chen, Zhuo; Cao, Lixin; Wang, Yaxin; Huang, Rong; Sun, Xiaoting; Lv, Runyu; Wang, Huan
作者单位：Nankai University
摘要：Tremendous attention has been paid to the water-associated side reactions and zinc (Zn) dendrite growth on the electrode-electrolyte interface. However, the Zn pulverization that can cause continuous depletion of active Zn metal and exacerbate hydrogen evolution is severely neglected. Here, we disclose that the excessive Zn feeding that causes incomplete crystallization is responsible for Zn pulverization formation through analyzing the thermodynamic and kinetics process of Zn deposition. On t...
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作者：Wu, Shaoyuan; Rheindt, Frank E.; Zhang, Jin; Wang, Jiajia; Zhang, Lei; Quan, Cheng; Li, Zhiheng; Wang, Min; Wu, Feixiang; Qu, Yanhua; Edwards, Scott, V; Zhou, Zhonghe; Liu, Liang
作者单位：Jiangsu Normal University; National University of Singapore; Changsha University of Science & Technology; Chang'an University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Harvard University; University System of Georgia; University of Georgia
摘要：The phylogeny and divergence timing of the Neoavian radiation remain controversial despite recent progress. We analyzed the genomes of 124 species across all Neoavian orders, using data from 25,460 loci spanning four DNA classes, including 5,756 coding sequences, 12,449 conserved nonexonic elements, 4,871 introns, and 2,384 intergenic segments. We conducted a comprehensive sensitivity analysis to account for the heterogeneity across different DNA classes, leading to an optimal tree of Neoaves ...
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作者：Yang, Yanyan; Wu, Gang; Sancar, Aziz; Hogenesch, John B.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center
摘要：One important goal of circadian medicine is to apply time- of- day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism- based clinical application. We studied time- series genome- wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (Cry1-/-Cry2-/-, Per1-/-Per2-/-, and Bmal1-/-). Rhythmic repair on the nontranscribed strand was lost in ...
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作者：Rains, Stephen A.; Richards, Adam S.
作者单位：University of Arizona
摘要：During the COVID- 19 pandemic, some US states mandated vaccination for certain citizens. We used state- level data from the CDC to test whether vaccine mandates predicted changes in COVID- 19 vaccine uptake, as well as related voluntary behaviors involving COVID- 19 boosters and seasonal influenza vaccines. Results showed that COVID- 19 vaccine adoption did not significantly change in the weeks before and after states implemented vaccine mandates, suggesting that mandates did not directly impa...
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作者：Davidson, Michael R.; Filatova, Tatiana; Peng, Wei; Verbeek, Liz; Kucuksayacigil, Fikri
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Delft University of Technology; Princeton University; Princeton University
摘要：Sustainability outcomes are influenced by the laws and configurations of natural and engineered systems as well as activities in socio- economic systems. An important subset of human activity is the creation and implementation of institutions, formal and informal rules shaping a wide range of human behavior. Understanding these rules and codifying them in computational models can provide important missing insights into why systems function the way they do (static) as well as the pace and struc...
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作者：Casey, Joan A.; Kioumourtzoglou, Marianthi-Anna; Padula, Amy; Gonzalez, David J. X.; Elser, Holly; Aguilera, Rosana; Northrop, Alexander J.; Tartof, Sara Y.; Mayeda, Elizabeth Rose; Braun, Danielle; Dominici, Francesca; Eisen, Ellen A.; Morello-Frosch, Rachel; Benmarhnia, Tarik
作者单位：Columbia University; University of Washington; University of Washington Seattle; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Pennsylvania; University of California System; University of California San Diego; Scripps Institution of Oceanography; Columbia University; Kaiser Permanente; University of California System; University of California Los Angeles; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Wildfires have become more frequent and intense due to climate change and outdoor wildfire fine particulate matter (PM2.5) concentrations differ from relatively smoothly varying total PM2.5. Thus, we introduced a conceptual model for computing long-term wildfire PM2.5 and assessed disproportionate exposures among marginalized communities. We used monitoring data and statistical techniques to characterize annual wildfire PM2.5 exposure based on intermittent and extreme daily wildfire PM2.5 conc...
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作者：Chennakesavalu, Shriram; Manikandan, Sreekanth K.; Hu, Frank; Rotskoff, Grant M.
作者单位：Stanford University; Stanford University
摘要：The adaptive and surprising emergent properties of biological materials self -assembled in far -from -equilibrium environments serve as an inspiration for efforts to design nanomaterials. In particular, controlling the conditions of self -assembly can modulate material properties, but there is no systematic understanding of either how to parameterize external control or how controllable a given material can be. Here, we demonstrate that branched actin networks can be encoded with metamaterial ...
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作者：Menand, Nicolas; Seshadhri, C.
作者单位：University of Pennsylvania; University of California System; University of California Santa Cruz
摘要：Graph representation learning is a fundamental technique for machine learning (ML) success in link prediction. On closer investigation, we observe that the performance is measured by the AUC (area under the curve), which suffers biases. Since the ground truth in link prediction is sparse, we design a vertex-centric measure of performance, called the VCMPR@k plots. Under this measure, we show that link predictors using graph representations show poor scores. Despite having extremely high AUC sc...
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作者：Pan, Jun; Liu, Yanhong; Yang, Jian; Wu, Jiawen; Fan, Hong Jin
作者单位：Nanyang Technological University; Shandong University
摘要：Oxidation self- charging batteries have emerged with the demand for powering electronic devices around the clock. The low efficiency of self- charging has been the key challenge at present. Here, a more efficient autoxidation self- charging mechanism is realized by introducing hemoglobin (Hb) as a positive electrode additive in the polyaniline (PANI)-zinc battery system. The heme acts as a catalyst that reduces the energy barrier of the autoxidation reaction by regulating the charge and spin s...
