8期

最新文章

• Bio- catalyzed oxidation selfcharging zinc-polymer batteries AI翻译
  作者：Pan, Jun; Liu, Yanhong; Yang, Jian; Wu, Jiawen; Fan, Hong Jin
  作者单位：Nanyang Technological University; Shandong University
  摘要：Oxidation selfcharging batteries have emerged with the demand for powering electronic devices around the clock. The low efficiency of selfcharging has been the key challenge at present. Here, a more efficient autoxidation selfcharging mechanism is realized by introducing hemoglobin (Hb) as a positive electrode additive in the polyaniline (PANI) - zinc battery system. The heme acts as a catalyst that reduces the energy barrier of the autoxidation reaction by regulating the charge and spin state...
• Functional constraints on the number and shape of flight feathers AI翻译
  作者：Kiat, Yosef; O'Connor, Jingmai K.
  作者单位：Field Museum of Natural History (Chicago)
  摘要：As a fundamental ecological aspect of most organisms, locomotor function significantly constrains morphology. At the same time, the evolution of novel locomotor abilities has produced dramatic morphological transformations, initiating some of the most significant diversifications in life history. Despite significant new fossil evidence, it remains unclear whether volant locomotion had a single or multiple origins in pennaraptoran dinosaurs and the volant abilities of individual taxa are contro...
• Metabolism of host lysophosphatidylcholine in Plasmodium falciparum-infected erythrocytes AI翻译
  作者：Liu, Jiapeng; Fike, Katherine R.; Dapper, Christie; Klemba, Michael
  作者单位：Virginia Polytechnic Institute & State University
  摘要：The human malaria parasite Plasmodium falciparum requires exogenous fatty acids to support its growth during the pathogenic, asexual erythrocytic stage. Host serum lysophosphatidylcholine (LPC) is a significant fatty acid source, yet the metabolic processes responsible for the liberation of free fatty acids from exogenous LPC are unknown. Using an assay for LPC hydrolysis in P. falciparum-infected erythrocytes, we have identified small- molecule inhibitors of key in situ lysophospholipase acti...
• Contribution of protein conformational heterogeneity to NMR lineshapes at cryogenic temperatures AI翻译
  作者：Yi, Xu; Fritzsching, Keith J.; Rogawski, Rivkah; Xu, Yunyao; McDermott, Ann E.
  作者单位：Columbia University
  摘要：While low- temperature Nuclear Magnetic Resonance (NMR) holds great promise for the analysis of unstable samples and for sensitizing NMR detection, spectral broadening in frozen protein samples is a common experimental challenge. One hypothesis explaining the additional linewidth is that a variety of conformations are in rapid equilibrium at room temperature and become frozen, creating an inhomogeneous distribution at cryogenic temperatures. Here, we investigate conformational heterogeneity by...
• Evidence supports a causal association between allele- specific vitamin D receptor binding and multiple sclerosis among Europeans AI翻译
  作者：Adams, Cameron; Manouchehrinia, Ali; Quach, Hong L.; Quach, Diana L.; Olsson, Tomas; Kockum, Ingrid; Schaefer, Catherine; Ponting, Chris P.; Alfredsson, Lars; Barcellos, Lisa F.
  作者单位：University of California System; University of California Berkeley; Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; Kaiser Permanente; University of Edinburgh; Karolinska Institutet
  摘要：Although evidence exists for a causal association between 25- hydroxyvitamin D (25(OH) D) serum levels, and multiple sclerosis (MS), the role of variation in vitamin D receptor (VDR) binding in MS is unknown. Here, we leveraged previously identified variants associated with allele imbalance in VDR binding (VDR- binding variant; VDR-BV) in ChIP-exo data from calcitriol- stimulated lymphoblastoid cell lines and 25(OH)D serum levels from genome-wide association studies to construct genetic instru...
• A submerged Stone Age hunting architecture from the Western Baltic Sea AI翻译
  作者：Geersen, Jacob; Bradtmoeller, Marcel; Deimling, Jens Schneider von; Feldens, Peter; Auer, Jens; Held, Philipp; Lohrberg, Arne; Supka, Ruth; Hoffmann, Jasper Justus Lutz; Eriksen, Berit Valentin; Rabbel, Wolfgang; Karlsen, Hans-Joerg; Krastel, Sebastian; Brandt, David; Heuskin, David; Luebke, Harald
  作者单位：University of Kiel; Leibniz Institut fur Ostseeforschung Warnemunde; University of Rostock; University of Rostock; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; University of Malta; Helmholtz Association; German Aerospace Centre (DLR)
  摘要：The Baltic Sea basins, some of which only submerged in the mid- Holocene, preserve Stone Age structures that did not survive on land. Yet, the discovery of these features is challenging and requires cross- disciplinary approaches between archeology and marine geosciences. Here, we combine shipborne and autonomousunderwater vehicle hydroacoustic data with up to a centimeter range resolution, sedimentological samples, and optical images to explore a Stone Age megastructure located in 21 m water ...
• Mineral carbonation of peridotite fueled by magmatic degassing and melt impregnation in an oceanic transform fault AI翻译
  作者：Klein, Frieder; Schroeder, Timothy; John, Cedric M.; Davis, Simon; Humphris, Susan E.; Seewald, Jeffrey S.; Sichel, Susanna; Bach, Wolfgang; Brunelli, Daniele
  作者单位：University of London; Queen Mary University London; Woods Hole Oceanographic Institution; Imperial College London; Woods Hole Oceanographic Institution; Universidade Federal Fluminense; University of Bremen; University of Bremen; Universita di Modena e Reggio Emilia
  摘要：Most of the geologic CO2 entering Earth's atmosphere and oceans is emitted along plate margins. While C- cycling at mid - ocean ridges and subduction zones has been studied for decades, little attention has been paid to degassing of magmatic CO2 and mineral carbonation of mantle rocks in oceanic transform faults. We studied the formation of soapstone (magnesite-talc rock) and other magnesite- bearing assemblages during mineral carbonation of mantle peridotite in the St. Paul's transform fault,...
• Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis AI翻译
  作者：Kowalewska, Paulina M.; Milkovich, Stephanie L.; Goldman, Daniel; Sandow, Shaun L.; Ellis, Christopher G.; Welsh, Donald G.
  作者单位：Western University (University of Western Ontario); University Western Ontario Hospital; Western University (University of Western Ontario); Western University (University of Western Ontario); University of the Sunshine Coast; University of Queensland
  摘要：Coupling red blood cell (RBC) supply to O2 demand is an intricate process requiring O2 sensing, generation of a stimulus, and signal transduction that alters upstream arteriolar tone. Although actively debated, this process has been theorized to be induced by hypoxia and to involve activation of endothelial inwardly rectifying K+ channels (KIR) 2.1 by elevated extracellular K+ to trigger conducted hyperpolarization via connexin40 (Cx40) gap junctions to upstream resistors. This concept was tes...
• Languages and future- oriented economic behavior-Experimental evidence for causal effects (Vol 120, e2208871120, 2023) AI翻译
  作者：Ayres, Ian; Katz, Tamar Kricheli; Regev, Tali
• Methyltransferase Setd2 prevents T cell-mediated autoimmune diseases via phospholipid remodeling AI翻译
  作者：Chen, Yali; Chen, Kun; Zhu, Ha; Qin, Hua; Liu, Juan; Cao, Xuetao
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Naval Medical University; Tongji University; Nankai University
  摘要：Coordinated metabolic reprogramming and epigenetic remodeling are critical for mod-ulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obscure. Here, we find that Setd2, a histone H3K36 trimethyltransferase, suppresses Th17 develop-ment but promotes iTreg cell polarization via phospholipid remodeling. Mechanistically, Setd2 up- regulates transcriptional expression of lysophosphatidylcholine ac...