8期

最新文章

• Arranged cohabitation among Chinese Muslims AI翻译
  作者：Mu, Zheng; Lai, Qing; Xie, Yu
  作者单位：National University of Singapore; State University System of Florida; Florida International University; Princeton University; Peking University
  摘要：While modern family- related ideas and behaviors have become more widely accepted in contemporary China, Chinese Muslim minorities continue to hold on to traditional religious practices. Surprisingly, data from our survey conducted in Gansu province in China's northwestern borderlands reveal that Muslims of the Hui and Dongxiang ethnicities reported much higher rates of cohabitation experience than the secular majority Han. Based on follow-up qualitative interviews, we found the answer to lie ...
• Reevaluating the deaths of despair narrative: Racial/ethnic heterogeneity in the trend of psychological distress- related death AI翻译
  作者：Zheng, Hui; Choi, Yoonyoung
  作者单位：University System of Ohio; Ohio State University; University of Hong Kong
  摘要：Despite the significant scientific advancement in deciphering the deaths of despair narrative, most relevant studies have focused on drug- , alcohol- , and suicide- related (DAS) deaths. This study directly investigated despair as a determinant of death and the temporal variation and racial heterogeneity among individuals. We used psychological distress (PD) as a proxy for despair and drew data from the US National Health Interview Survey- Linked Mortality Files 1997 to 2014, CDC (Centers for ...
• Episodic fluid venting from sedimentary basins fueled by pressurized mudstones AI翻译
  作者：Kearney, Luke M.; Katz, Richard F.; Macminn, Christopher W.; Kirkham, Chris; Cartwright, Joe
  作者单位：University of Oxford; University of Oxford
  摘要：Subsurface sandstone reservoirs sealed by overlying, low -permeability layers provide capacity for long-term sequestration of anthropogenic waste. Leakage can occur if reservoir pressures rise sufficiently to fracture the seal. Such pressures can be generated within the reservoir by vigorous injection of waste or, over thousands of years, by natural processes. In either case, the precise role of intercalated mudstones in the long-term evolution of reservoir pressure remains unclear; these laye...
• Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells AI翻译
  作者：Liu, Qiang; Luo, Xing; Liang, Ziqi; Qin, Dezhe; Xu, Mingyue; Wang, Min; Guo, Weixiang
  作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The circadian clock throughout the day organizes the activity of neural stem cells (NSCs) in the dentate gyrus (DG) of adult hippocampus temporally. However, it is still unclear whether and how circadian signals from the niches contribute to daily rhythmic variation of NSC activation. Here, we show that norepinephrinergic (NEergic) projections from the locus coeruleus (LC), a brain arousal system, innervate into adult DG, where daily rhythmic release of norepinephrine (NE) from the LC NEergic ...
• Enhanced charge- carrier dynamics and efficient solar- to- urea conversion on Si- based photocathodes AI翻译
  作者：Zhang, Xiaoran; Lyu, Yanhong; Chen, Chen; Zheng, Jianyun; Jiang, San Ping; Wang, Shuangyin
  作者单位：Hunan University; Curtin University; Advanced Energy Science & Technology Guangdong Laboratory; Foshan Xianhu Laboratory
  摘要：Photoelectrochemical (PEC) coupling of CO2 and nitrate can provide a useful and green source of urea, but the process is affected by the photocathodes with poor charge- carrier dynamics and low conversion efficiency. Here, a NiFe diatomic catalysts/TiO2 layer/nanostructured n+p- Si photocathode is rationally designed, achieving a good charge- separation efficiency of 78.8% and charge- injection efficiency of 56.9% in the process of PEC urea synthesis. Compared with the electrocatalytic urea sy...
• Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions AI翻译
  作者：Ma, Weikang; del Rio, Carlos L.; Qi, Lin; Prodanovic, Momcilo; Mijailovich, Srboljub; Zambataro, Christopher; Gong, Henry; Shimkunas, Rafael; Gollapudi, Sampath; Nag, Suman; Irving, Thomas C.
  作者单位：Illinois Institute of Technology; Illinois Institute of Technology; Bristol-Myers Squibb; Illinois Institute of Technology; University of Kragujevac
  摘要：Mavacamten is a FDA- approved small- molecule therapeutic designed to regulate cardiac function at the sarcomere level by selectively but reversibly inhibiting the enzymatic activity of myosin. It shifts myosin toward ordered offstates close to the thick filament backbone. It remains elusive whether these myosin heads in the offstate(s) can be recruited in response to physiological stimuli when required to boost cardiac output. We show that cardiac myosins stabilized in these offstate(s) by ma...
• Homophily modulates double descent generalization in graph convolution networks AI翻译
  作者：Shi, Cheng; Pan, Liming; Hu, Hong; Dokmanic, Ivan
  作者单位：University of Basel; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nanjing Normal University; University of Pennsylvania; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Graph neural networks (GNNs) excel in modeling relational data such as biological, statistical physics and random matrix theory to precisely characterize generalization in simple graph convolution networks on the contextual stochastic block model. Our results illuminate the nuances of learning on homophilic versus heterophilic data and predict double descent whose existence in GNNs has been questioned by recent work. We show how risk is shaped by the interplay between the graph noise, feature ...
• The impact of age and number of mutations on the size of clonal hematopoiesis AI翻译
  作者：Wang, Kai; Zhang, Wen; Yi, Li; Zhao, Ming; Li, Peng - Yu; Fu, Mei - Hong; Lin, Rong; Zhu, Yong - Mei; Li, Jian - Feng; Yang, Wei - Ping; Fang, Hai; Chen, Zhu; Cai, Wang - Wei; Ren, Rui - Bao
  作者单位：Hainan Medical University; Hainan Medical University; Chinese Academy of Sciences; Shanghai Jiao Tong University; Hainan Medical University; Hainan Medical University
  摘要：Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for disease prevention and clinical decision- making. The size of CH has been showed to associate with higher disease risk, yet, factors influencing the size of CH are unknown. In addition, the characteristics of CH in long - lived individuals are not well documented. Here, we report an in - depth analysis of CH in longe...
• The 10,000-year biocultural history of fallow deer and its implications for conservation policy AI翻译
  作者：Baker, Karis H.; Miller, Holly; Doherty, Sean; Gray, Howard W. I.; Daujat, Julie; Cakirlar, Canan; Spassov, Nikolai; Trantalidou, Katerina; Madgwick, Richard; Lamb, Angela L.; Ameen, Carly; Atici, Levent; Baker, Polydora; Beglane, Fiona; Benkert, Helene; Bendrey, Robin; Roman, Annelise Binois -; Carden, Ruth F.; Curci, Antonio; De Cupere, Bea; Detry, Cleia; Gal, Erika; Genies, Chloe; Kunst, Guenther K.; Liddiard, Robert; Nicholson, Rebecca; Perdikaris, Sophia; Peters, Joris; Pigiere, Fabienne; Pluskowski, Aleksander G.; Sadler, Peta; Sicard, Sandra; Strid, Lena; Sudds, Jack; Symmons, Robert; Tardio, Katie; Valenzuela, Alejandro; van Veen, Monique; Vukovic, Sonja; Weinstock, Jaco; Wilkens, Barbara; Wilson, Roger J. A.; Evans, Jane A.; Hoelzel, A. Rus; Sykes, Naomi
  作者单位：Durham University; University of Nottingham; University of Exeter; University of Groningen; Bulgarian Academy of Sciences; Cardiff University; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Atlantic Technological University (ATU); University of Edinburgh; University College Dublin; University of Bologna; Royal Belgian Institute of Natural Sciences; Universidade de Lisboa; HUN-REN; HUN-REN Research Centre for the Humanities; University of Vienna; University of Nebraska System; University of Nebraska Lincoln; University of Munich; University of London; Royal Holloway University London; University of Reading; Lund University; Bucknell University; University of Belgrade; University of Southampton
  摘要：Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no consensus regarding their natural ranges or the timing and circumstances of their human- mediated tra...
• CFTR is required for zinc- mediated antibacterial defense in human macrophages AI翻译
  作者：Das Gupta, Kaustav; Curson, James E. B.; Tarique, Abdullah A.; Kapetanovic, Ronan; Schembri, Mark A.; Fantino, Emmanuelle; Sly, Peter D.; Sweet, Matthew J.
  作者单位：University of Queensland; University of Queensland; University of Queensland; Friedrich Miescher Institute for Biomedical Research; Universite de Tours; INRAE; University of Queensland
  摘要：Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion transporter required for epithelial homeostasis in the lung and other organs, with CFTR mutations leading to the autosomal recessive genetic disease CF. Apart from excessive mucus accumulation and dysregulated inflammation in the airways, people with CF (pwCF) exhibit defective innate immune responses and are susceptible to bacterial respiratory pathogens such as Pseudomonas aeruginosa. Here, we investigated the role of CFT...