8期

最新文章

• Indications of flat bands driving the δ to a volume collapse of plutonium AI翻译
  作者：Harrison, Neil; Chappell, Greta L.; Tobash, Paul H.
  作者单位：United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Los Alamos National Laboratory
  摘要：On cooling from the melt, plutonium (Pu) undergoes a series of structural transformations accompanied by a approximate to 28% reduction in volume from its delta phase to its a phase at low temperatures. While Pu's partially filled 5f -electron shells are known to be involved, their precise role in the transformations has remained unclear. By using calorimetry measurements on a-Pu and gallium -stabilized delta-Pu combined with resonant ultrasound and X-ray scattering data to account for the ano...
• YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P AI翻译
  作者：Hong, Hye- Rim; Prince, Cassidy R.; Tetreault, Daniel D.; Wu, Letian; Feaga, Heather A.
  作者单位：Cornell University
  摘要：Protein synthesis is performed by the ribosome and a host of highly conserved elongation factors. Elongation factor P (EF-P) prevents ribosome stalling at difficult - to- translate sequences, such as polyproline tracts. In bacteria, phenotypes associated with efp deletion range from modest to lethal, suggesting that some species encode an additional translation factor that has similar function to EF-P. Here we identify YfmR as a translation factor that is essential in the absence of EF-P in Ba...
• Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis AI翻译
  作者：Mahabadi, Hajar Miranzadeh; Lin, Y. C. James; Ogando, Natacha S.; Moussa, Eman W.; Mohammadzadeh, Nazanin; Julien, Oliver; Alto, Neal M.; Noyce, Ryan S.; Evans, David H.; Power, Christopher
  作者单位：University of Alberta; University of Alberta; University of Alberta; University of Texas System; University of Texas Southwestern Medical Center; University of Alberta
  摘要：Monkeypox virus (MPXV) infections in humans cause neurological disorders while studies of MPXV- infected animals indicate that the virus penetrates the brain. Pyroptosis is an inflammatory type of regulated cell death, resulting from plasma membrane rupture (PMR) due to oligomerization of cleaved gasdermins to cause membrane pore formation. Herein, we investigated the human neural cell tropism of MPXV compared to another orthopoxvirus, vaccinia virus (VACV), as well as its effects on immune re...
• Enhancing ion selectivity by tuning solvation abilities of covalent- organic- framework membranes AI翻译
  作者：Meng, Qing-Wei; Zhu, Xincheng; Xian, Weipeng; Wang, Sai; Zhang, Zhengqing; Zheng, Liping; Dai, Zhifeng; Yin, Hong; Ma, Shengqian; Sun, Qi
  作者单位：Zhejiang University; Tiangong University; Zhejiang Sci-Tech University; University of North Texas System; University of North Texas Denton
  摘要：Understanding the molecular - level mechanisms involved in transmembrane ion selectivity is essential for optimizing membrane separation performance. In this study, we reveal our observations regarding the transmembrane behavior of Li + and Mg 2+ ions as a response to the changing pore solvation abilities of the covalent - organic - framework (COF) membranes. These abilities were manipulated by adjusting the lengths of the oligoether segments attached to the pore channels. Through comparative ...
• KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis AI翻译
  作者：Xie, Bingteng; Zhang, Mengdi; Li, Jie; Cui, Jianxin; Zhang, Pengju; Liu, Fangming; Wu, Yuxi; Deng, Weiwei; Ma, Jihong; Li, Xinyu; Pan, Bingchen; Zhang, Baohui; Zhang, Hongbing; Luo, Aiqin; Xu, Yinzhe; Li, Mo; Pu, Yang
  作者单位：Beijing Institute of Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese People's Liberation Army General Hospital; Chinese People's Liberation Army General Hospital; University of Virginia; China Medical University; Chinese People's Liberation Army General Hospital
  摘要：Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by excessive glycolysis metabolism. However, the regulatory molecules and downstream protein targets of Kla remain largely unclear. Here, we observed a global Kla abundance profile in colorectal cancer (CRC) that negatively correlates with prognosis. Among lactylated proteins detected in CRC, lactylation of eEF1A2K408 resulted in boosted translation elongation and enhanced protein synthesis which contributed...
• A comprehensive patient- specific prediction model for temporomandibular joint osteoarthritis progression AI翻译
  作者：Al Turkestani, Najla; Li, Tengfei; Bianchi, Jonas; Gurgel, Marcela; Prieto, Juan; Shah, Hina; Benavides, Erika; Soki, Fabiana; Mishina, Yuji; Fontana, Margherita; Rao, Arvind; Zhu, Hongtu; Cevidanes, Lucia
  作者单位：King Abdulaziz University; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of the Pacific; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Temporomandibular joint osteoarthritis (TMJ OA) is a prevalent degenerative disease characterized by chronic pain and impaired jaw function. The complexity of TMJ OA has hindered the development of prognostic tools, posing a significant challenge in timely, patient- specific management. Addressing this gap, our research employs a comprehensive, multidimensional approach to advance TMJ OA prognostication. We conducted a prospective study with 106 subjects, 74 of whom were followed up after 2 to...
• Dynamic electrical synapses rewire brain networks for persistent oscillations and epileptogenesis AI翻译
  作者：Yang, Ya-Chi; Wang, Guan- Hsun; Chou, Ping; Hsueh, Shu- Wei; Lai, Yi- Chen; Kuo, Chung-Chin
  作者单位：Chang Gung University; Chang Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; National Taiwan University; National Taiwan University; National Taiwan University Hospital
  摘要：One of the very fundamental attributes for telencephalic neural computation in mammals involves network activities oscillating beyond the initial trigger. The continuing and automated processing of transient inputs shall constitute the basis of cognition and intelligence but may lead to neuropsychiatric disorders such as epileptic seizures if carried so far as to engross part of or the whole telencephalic system. From a conventional view of the basic design of the telencephalic local circuitry...
• Cochlear zinc signaling dysregulation is associated with noise- induced hearing loss, and zinc chelation enhances cochlear recovery AI翻译
  作者：Bizup, Brandon; Brutsaert, Sofie; Cunningham, Christopher L.; Thathiah, Amantha; Tzounopoulos, Thanos
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Exposure to loud noise triggers sensory organ damage and degeneration that, in turn, leads to hearing loss. Despite the troublesome impact of noise- induced hearing loss (NIHL) in individuals and societies, treatment strategies that protect and restore hearing are few and insufficient. As such, identification and mechanistic understanding of the signaling pathways involved in NIHL are required. Biological zinc is mostly bound to proteins, where it plays major structural or catalytic roles; how...
• Modeling blood metabolite homeostatic levels reduces sample heterogeneity across cohorts AI翻译
  作者：Liu, Danni; Gowda, G. A. Nagana; Jiang, Zhongli; Alemdjrodo, Kangni; Zhang, Min; Zhang, Dabao; Raftery, Daniel
  作者单位：Purdue University System; Purdue University; University of Washington; University of Washington Seattle; University of California System; University of California Irvine
  摘要：Blood metabolite levels are affected by numerous factors, including preanalytical factors such as collection methods and geographical sites. These perturbations have caused deleterious consequences for many metabolomics studies and represent a major chal- lenge in the metabolomics field. It is important to understand these factors and develop models to reduce their perturbations. However, to date, the lack of suitable mathematical models for blood metabolite levels under homeostasis has hinder...
• Multimodal neuro- nanotechnology: Challenging the existing paradigm in glioblastoma therapy AI翻译
  作者：Kudruk, Sergej; Forsyth, Connor M.; Dion, Michelle Z.; Orbeck, Jenny K. Hedlund; Luo, Jingqin; Klein, Robyn S.; Kim, Albert H.; Heimberger, Amy B.; Mirkin, Chad A.; Stegh, Alexander H.; Artzi, Natalie
  作者单位：Northwestern University; Northwestern University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Siteman Cancer Center; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University; Feinberg School of Medicine; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Integrating multimodal neuro- and nanotechnologyenabled precision immunotherapies with extant systemic immunotherapies may finally provide a significant breakthrough for combatting glioblastoma (GBM). The potency of this approach lies in its ability to train the immune system to efficiently identify and eradicate cancer cells, thereby creating anti- tumor immune memory while minimizing multi- mechanistic immune suppression. A critical aspect of these therapies is the controlled, spatiotemporal...