8期

最新文章

• Causally estimating the effect of YouTube's recommender system using counterfactual bots AI翻译
  作者：Hosseinmardi, Homa; Ghasemian, Amir; Rivera-Lanas, Miguel; Ribeiro, Manoel Horta; West, Robert; Bail, Christopher A.
  作者单位：University of Pennsylvania; University of Pennsylvania; Yale University; Carnegie Mellon University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Pennsylvania
  摘要：the effects of the algorithm from a user's intentions. Here we propose a method that we call counterfactual bots to causally estimate the role of algorithmic recommendations on the consumption of highly partisan content on YouTube. By comparing bots that replicate real users' consumption patterns with counterfactual bots that follow rule-based trajectories, we show that, on average, relying exclusively on the YouTube recommender results in less partisan consumption, where the effect is most pr...
• Phosphorylation of the alpha- I motif in SYMRK drives root nodule organogenesis AI翻译
  作者：Abel, Nikolaj B.; Norgaard, Malita M. M.; Hansen, Simon B.; Gysel, Kira; Diez, Ignacio Arribas; Jensen, Ole N.; Stougaard, Jens; Andersen, Kasper R.
  作者单位：Aarhus University; University of Southern Denmark
  摘要：Symbiosis receptor- like kinase SYMRK is required for root nodule symbiosis between legume plants and nitrogen- fixing bacteria. To understand symbiotic signaling from SYMRK, we determined the crystal structure to 1.95 angstrom and mapped the phosphorylation sites onto the intracellular domain. We identified four serine residues in a conserved alpha- I motif, located on the border between the kinase core domain and the flexible C- terminal tail, that, when phosphorylated, drives organogenesis....
• Two- pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes AI翻译
  作者：Chadwick, Sarah R.; Barreda, Dante; Wu, Jing Ze; Ye, Gang; Yusuf, Bushra; Ren, Dejian; Hilgemann, Donald
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Pennsylvania
  摘要：Phagocytes promptly resolve ingested targets to replenish lysosomes and maintain their responsiveness. The resolution process requires that degradative hydrolases, solute transporters, and proteins involved in lipid traffic are delivered and made active in phagolysosomes. It also involves extensive membrane remodeling. We report that cation channels that localize to phagolysosomes were essential for resolution. Specifically, the conductance of Na+ by two - pore channels (TPCs) and the presence...
• Heterogeneous osteoimmune profiles via single- cell transcriptomics in osteoporotic patients who fail bisphosphonate treatment AI翻译
  作者：Keum, Byeong - Rak; Kim, Hong Jin; Lee, Juhun; Lee, Minji; Hong, Sin - Hyoung; Chang, Ha Kyun; Han, Jin - Kwan; Kim, Sanguk; Chang, Dong - Gune; Kim, Gun - Hwa
  作者单位：Pohang University of Science & Technology (POSTECH); Inje University; Korea Basic Science Institute (KBSI); University of Science & Technology (UST); Korea University; Korea University Medicine (KU Medicine); Yonsei University; Chungnam National University
  摘要：Postmenopausal osteoporosis arises from imbalanced osteoclast and osteoblast activity, and mounting evidence suggests a role for the osteoimmune system in bone homeostasis. Bisphosphonate (BP) is an antiresorptive agent, but its treatment failure rate can be as high as 40%. Here, we performed single - cell RNA sequencing on peripheral immune cells from carefully selected postmenopausal women: non- osteoporotic, osteoporosis improved after BP treatment, and BP- failed cases. We found an increas...
• Maximally localized Wannier functions, interaction models, and fractional quantum anomalous Hall effect in twisted bilayer MoTe2 AI翻译
  作者：Xu, Cheng; Li, Jiangxu; Xu, Yong; Bi, Zhen; Zhang, Yang
  作者单位：University of Tennessee System; University of Tennessee Knoxville; Tsinghua University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Tennessee System; University of Tennessee Knoxville
  摘要：We investigate the moire band structures and the strong correlation effects in twisted bilayer MoTe2 for a wide range of twist angles, employing a combination of various techniques. Using large-scale first -principles calculations, we pinpoint realistic continuum modeling parameters, subsequently deriving the maximally localized Wannier functions for the top three moire bands. Simplifying our model with reasonable assumptions, we obtain a minimal two -band model, encompassing Coulomb repulsion...
• Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation AI翻译
  作者：Molin, Arnaud N.; Contentin, Romain; Angelozzi, Marco; Karvande, Anirudha; Kc, Ranjan; Haseeb, Abdul; Voskamp, Chantal; de Charleroy, Charles; Lefebvre, Veronique
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
  摘要：SOX8 was linked in a genome-wide association study to human height heritability, but roles in chondrocytes for this close relative of the master chondrogenic transcription factor SOX9 remain unknown. We undertook here to fill this knowledge gap. High- throughput assays demonstrate expression of human SOX8 and mouse Sox8 in growth plate cartilage. In situ assays show that Sox8 is expressed at a similar level as Sox9 in reserve and early columnar chondrocytes and turned off when Sox9 expression ...
• Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production AI翻译
  作者：Noch, Evan K.; Palma, Laura; Yim, Isaiah; Bullen, Nayah; Barnett, Daniel; Walsh, Alexander; Bhinder, Bhavneet; Benedetti, Elisa; Krumsiek, Jan; Gurvitch, Justin; Khwaja, Sumaiyah; Atlas, Daphne; Elemento, Olivier; Cantley, Lewis C.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Hebrew University of Jerusalem; Harvard University; Harvard Medical School
  摘要：Glucose and amino acid metabolism are critical for glioblastoma (GBM) growth, but little is known about the specific metabolic alterations in GBM that are targetable with FDA- approved compounds. To investigate tumor metabolism signatures unique to GBM, we interrogated The Cancer Genome Atlas for alterations in glucose and amino acid signatures in GBM relative to other human cancers and found that GBM exhibits the highest levels of cysteine and methionine pathway gene expression of 32 human ca...
• Dynamic fading memory and expectancy effects in the monkey primary visual cortex AI翻译
  作者：Yang, Yiling; Klon-Lipok, Johanna; Shapcott, Katharine; Lazar, Andreea; Singer, Wolf
  作者单位：Max Planck Society; Max Planck Society
  摘要：In order to investigate the involvement of the primary visual cortex (V1) in working memory (WM), parallel, multisite recordings of multi - unit activity were obtained from monkey V1 while the animals performed a delayed match - to- sample (DMS) task. During the delay period, V1 population firing rate vectors maintained a lingering trace of the sample stimulus that could be reactivated by intervening impulse stimuli that enhanced neuronal firing. This fading trace of the sample did not require...
• Phonon stability boundary and deep elastic strain engineering of lattice thermal conductivity AI翻译
  作者：Shi, Zhe; Tsymbalov, Evgenii; Shi, Wencong; Barr, Ariel; Li, Qingjie; Li, Jiangxu; Chen, Xing-Qiu; Dao, Ming; Suresh, Subra; Li, Ju
  作者单位：Massachusetts Institute of Technology (MIT); Nanyang Technological University; Chinese Academy of Sciences; Institute of Metal Research, CAS; Massachusetts Institute of Technology (MIT); Nanyang Technological University
  摘要：Recent studies have reported the experimental discovery that nanoscale specimens of even a natural material, such as diamond, can be deformed elastically to as much as 10% tensile elastic strain at room temperature without the onset of permanent dam-age or fracture. Computational work combining ab initio calculations and machine learning (ML) algorithms has further demonstrated that the bandgap of diamond can be altered significantly purely by reversible elastic straining. These findings open ...
• Fine- tuning activation specificity of G- protein- coupled receptors via automated path searching AI翻译
  作者：Ti, Rujuan; Pang, Bin; Yu, Leiye; Gan, Bing; Ma, Wenzhuo; Warshel, Arieh; Ren, Ruobing; Zhu, Lizhe
  作者单位：The Chinese University of Hong Kong, Shenzhen; Fudan University; The Chinese University of Hong Kong, Shenzhen; University of Southern California; Shanghai Qi Zhi Institute
  摘要：Physics - based simulation methods can grant atomistic insights into the molecular origin of the function of biomolecules. However, the potential of such approaches has been hindered by their low efficiency, including in the design of selective agonists where simulations of myriad protein-ligand combinations are necessary. Here, we describe an automated input - free path searching protocol that offers (within 14 d using Graphics Processing Unit servers) a minimum free energy path (MFEP) define...