8期

最新文章

• Model selection over partially ordered sets AI翻译
  作者：Taeb, Armeen; Buhlmann, Peter; Chandrasekaran, Venkat
  作者单位：University of Washington; University of Washington Seattle; California Institute of Technology; California Institute of Technology
  摘要：In problems such as variable selection and graph estimation, models are characterized by Boolean logical structure such as the presence or absence of a variable or an edge. Consequently, false -positive error or false -negative error can be specified as the number of variables/edges that are incorrectly included or excluded in an estimated model. However, there are several other problems such as ranking, clustering, and causal inference in which the associated model classes do not admit transp...
• Circular RNAs from linear viral RNA genomes: A distinct dimension in the virus world AI翻译
  作者：V. Koonin, Eugene
  作者单位：National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
• The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid- mediated subunit contacts in mechanosensory transduction AI翻译
  作者：Clark, Sarah; Jeong, Hanbin; Posert, Rich; Goehring, April; Gouaux, Eric
  作者单位：Oregon Health & Science University; Oregon Health & Science University
  摘要：Mechanotransduction is the process by which a mechanical force, such as touch, is converted into an electrical signal. Transmembrane channel - like (TMC) proteins are an evolutionarily conserved family of membrane proteins whose function has been linked to a variety of mechanosensory processes, including hearing and balance sensation in vertebrates and locomotion in Drosophila. TMC1 and TMC2 are components of ion channel complexes, but the molecular features that tune these complexes to divers...
• GABAB receptors induce phasic release from medial habenula terminals through activity- dependent recruitment of release- ready vesicles AI翻译
  作者：Koppensteiner, Peter; Bhandari, Pradeep; Oenal, Cihan; Merjane, Carolina Borges-; Le Monnier, Elodie; Roy, Utsa; Nakamura, Yukihiro; Sadakata, Tetsushi; Sanbo, Makoto; Hirabayashi, Masumi; Rhee, Jeongseop; Brose, Nils; Jonas, Peter; Shigemoto, Ryuichi
  作者单位：University of Basel; Institute of Science & Technology - Austria; Jikei University; Gunma University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS)
  摘要：GABAB receptor (GBR) activation inhibits neurotransmitter release in axon terminals in the brain, except in medial habenula (MHb) terminals, which show robust poten-tiation. However, mechanisms underlying this enigmatic potentiation remain elusive. Here, we report that GBR activation on MHb terminals induces an activity- dependent transition from a facilitating, tonic to a depressing, phasic neurotransmitter release mode. This transition is accompanied by a 4.1- fold increase in readily releas...
• Weakening warming on spring freeze-thaw cycle caused greening Earth's third pole AI翻译
  作者：Li, Jialing; Wu, Chaoyang; Zhang, Yongguang; Penuelas, Josep; Liu, Lei; Ge, Quansheng
  作者单位：Nanjing University; Nanjing University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Autonomous University of Barcelona; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Consejo Superior de Investigaciones Cientificas (CSIC); University of Barcelona; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Zhengzhou University
  摘要：The Tibetan Plateau, recognized as Earth's third pole and among the most responsive regions to climate shifts, profoundly influences regional and even global hydrological processes. Here, we discerned a significant weakening in the influence of temperature on the initiation of surface freeze-thaw cycle (the Start of Thawing, SOT), which can be ascribed to a multitude of climatic variables, with radiation emerging as the most pivotal factor. Additionally, we showed that the diminishing impact o...
• Languages and future- oriented economic behavior-Experimental evidence for causal effect (vol 120, e2208871120, 2023) AI翻译
  作者：Ayres, Ian; Katz, Tamar Kricheli; Regev, Tali
• The shocking story of the plastic bead that fixes nitrogen AI翻译
  作者：Vannoy, Kathryn J.; Dick, Jeffrey E.
  作者单位：Purdue University System; Purdue University
• The GATA transcriptional program dictates cell fate equilibrium to establish the maternal-fetal exchange interface and fetal development AI翻译
  作者：Ghosh, Ananya; Kumar, Rajnish; Kumar, Ram P.; Ray, Soma; Saha, Abhik; Roy, Namrata; Dasgupta, Purbasa; Marsh, Courtney; Paul, Soumen
  作者单位：University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center; University of Kansas; University of Kansas Medical Center; University of California System; University of California San Francisco
  摘要：The placenta establishes a maternal-fetal exchange interface to transport nutrients and gases between the mother and the fetus. Establishment of this exchange interface relies on the development of multinucleated syncytiotrophoblasts (SynT) from trophoblast progenitors, and defect in SynT development often leads to pregnancy failure and impaired embryonic development. Here, we show that mouse embryos with conditional deletion of transcription factors GATA2 and GATA3 in labyrinth trophoblast pr...
• Structure and function of the Si3 insertion integrated into the trigger loop/helix of cyanobacterial RNA polymerase AI翻译
  作者：Qayyum, M. Zuhaib; Imashimizu, Masahiko; Leanca, Miron; Vishwakarma, Rishi K.; Riaz-Bradley, Amber; Yuzenkova, Yulia; Murakami, Katsuhiko S.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Institute of Advanced Industrial Science & Technology (AIST); Newcastle University - UK; St Jude Children's Research Hospital
  摘要：Cyanobacteria and evolutionarily related chloroplasts of algae and plants possess unique RNA polymerases (RNAPs) with characteristics that distinguish them from canonical bacterial RNAPs. The largest subunit of cyanobacterial RNAP (cyRNAP) is divided into two polypeptides, beta ' 1 and beta ' 2, and contains the largest known lineage- specific insertion domain, Si3, located in the middle of the trigger loop and spanning approximately half of the beta ' 2 subunit. In this study, we present the ...
• Importance of magnetic information for neuronal plasticity in desert ants AI翻译
  作者：Grob, Robin; Mueller, Valentin L.; Gruebel, Kornelia; Roessler, Wolfgang; Fleischmann, Pauline N.
  作者单位：Norwegian University of Science & Technology (NTNU); University of Wurzburg; Carl von Ossietzky Universitat Oldenburg
  摘要：Many animal species rely on the Earth's magnetic field during navigation, but where in the brain magnetic information is processed is still unknown. To unravel this, we manipulated the natural magnetic field at the nest entrance of Cataglyphis desert ants and investigated how this affects relevant brain regions during early compass calibration. We found that manipulating the Earth's magnetic field has profound effects on neuronal plasticity in two sensory integration centers. Magnetic field ma...