OCA- B/Pou2af 1 is sufficient to promote CD4+T cell memory and prospectively identifies memory precursors

• 成果类型: Article
• 署名作者: Sun, Wenxiang; Hughes, Erik P.; Kim, Heejoo; Perovanovic, Jelena; Charley, Krystal R.; Perkins, Bryant; Du, Junhong; Ibarra, Andrea; Syage, Amber R.; Hale, J. Scott; Williams, Matthew A.; Tantin, Dean
• 署名单位: Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13070
• DOI: 10.1073/pnas.2309153121
• 发表日期: 2024-02-27
• 关键词: cd8(+) t-cells; transcription factor; effector; expression; virus; mice; differentiation; suppression; oct1; il-2

摘要

The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA- B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short- lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory precursor effector cells show increased expression of Bcl2, Il7r, and Tcf7 on a per- cell basis. Using central memory T cells. We show that early in viral infection, endogenously elevated OCA- B expression prospectively identifies memory precursor cells with increased survival capability and memory recall potential. Cumulatively, the results demonstrate that OCA- B is both necessary and sufficient to promote CD4 T cell memory in vivo and can be used to prospectively identify memory precursor cells.