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最新文章

• Mechanism of branching morphogenesis inspired by diatom silica formation AI翻译
  作者：Babenko, Iaroslav; Kroeger, Nils; Friedrich, Benjamin M.
  作者单位：Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden
  摘要：The silica -based cell walls of diatoms are prime examples of genetically controlled, species -specific mineral architectures. The physical principles underlying morphogenesis of their hierarchically structured silica patterns are not understood, yet such insight could indicate novel routes toward synthesizing functional inorganic materials. Recent advances in imaging nascent diatom silica allow rationalizing possible mechanisms of their pattern formation. Here, we combine theory and experimen...
• Low- frequency somatic mutations are heritable in tropical trees Dicorynia guianensis and Sextonia rubra AI翻译
  作者：Schmitt, Sylvain; Heuret, Patrick; Troispoux, Valerie; Beraud, Melanie; Cazal, Jocelyn; Chancerel, Emilie; Cravero, Charlotte; Guichoux, Erwan; Lepais, Olivier; Loureiro, Joao; Marande, William; Martin-Ducup, Olivier; Vincent, Gregoire; Chave, Jerome; Plomion, Christophe; Leroy, Thibault; Heuertz, Myriam; Tysklind, Niklas
  作者单位：Centre National de la Recherche Scientifique (CNRS); INRAE; AgroParisTech; CIRAD; CIRAD; Universite de Montpellier; CIRAD; Universite de Montpellier; CIRAD; INRAE; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); AgroParisTech; CIRAD; Centre National de la Recherche Scientifique (CNRS); INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Paris Saclay; CEA; INRAE; Universite de Bordeaux; INRAE; Universidade de Coimbra; INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Institut de Recherche pour le Developpement (IRD); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; University of Vienna; Universite de Toulouse; Ecole Nationale Veterinaire de Toulouse; INRAE
  摘要：Somatic mutations potentially play a role in plant evolution, but common expectations pertaining to plant somatic mutations remain insufficiently tested. Unlike in most animals, the plant germline is assumed to be set aside late in development, leading to the expectation that plants accumulate somatic mutations along growth. Therefore, several predictions were made on the fate of somatic mutations: mutations have generally low frequency in plant tissues; mutations at high frequency have a high...
• Saccharomycotina yeasts defy long- standing macroecological patterns AI翻译
  作者：David, Kyle T.; Harrison, Marie-Claire; Opulente, Dana A.; Labella, Abigail L.; Wolters, John F.; Zhou, Xiaofan; Shen, Xing-Xing; Groenewald, Marizeth; Pennell, Matt; Hittinger, Chris Todd; Rokas, Antonis
  作者单位：Vanderbilt University; Vanderbilt University; University of Wisconsin System; University of Wisconsin Madison; United States Department of Energy (DOE); Villanova University; University of North Carolina; University of North Carolina Charlotte; South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Zhejiang University; University of Southern California; University of Southern California
  摘要：The Saccharomycotina yeasts (yeasts hereafter) are a fungal clade of scientific, ecorecords and 96 environmental variables to infer global distribution maps at -1 km2 resolution for 186 yeast species (-15% of described species from 75% of orders) and to test environmental drivers of yeast biogeography and macroecology. We found that predicted yeast diversity hotspots occur in mixed montane forests in temperate climates. Diversity in vegetation type and topography were some of the greatest pred...
• Enhancing chimeric antigen receptor T cell therapy by modulating the p53 signaling network with Δ133p53α AI翻译
  作者：Roselle, Christopher; Horikawa, Izumi; Chen, Linhui; Kelly, Andre R.; Gonzales, Donna; Da, Tong; Wellhausen, Nils; Rommel, Philipp C.; Baker, Daniel; Suhoski, Megan; Scholler, John; O'Connor, Roddy S.; Young, Regina M.; Harris, Curtis C.; June, Carl H.
  作者单位：University of Pennsylvania; University of Pennsylvania; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Pennsylvania; University of Pennsylvania
  摘要：Chimeric antigen receptor (CAR) T cell dysfunction is a major barrier to achieving lasting remission in hematologic cancers, especially in chronic lymphocytic leukemia (CLL). have shown previously that A133p53 alpha, an endogenous isoform of the human TP53 gene, decreases in expression with age in human T cells, and that reconstitution of A133p53 alpha in poorly functional T cells can rescue proliferation [A. M. Mondal et al., J. Clin. Invest. 123, 5247-5257 (2013)]. Although A133p53 alpha lac...
• Genome copy number predicts extreme evolutionary rate variation in plant mitochondrial DNA AI翻译
  作者：Zwonitzer, Kendra D.; Tressel, Lydia G.; Wu, Zhiqiang; Kan, Shenglong; Broz, Amanda K.; Mower, Jeffrey P.; Ruhlman, Tracey A.; Jansen, Robert K.; Sloan, Daniel B.; Havird, Justin C.
  作者单位：University of Texas System; University of Texas Austin; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Guangdong Laboratory for Lingnan Modern Agriculture; Shandong University; Colorado State University System; Colorado State University Fort Collins; University of Nebraska System; University of Nebraska Lincoln
  摘要：Nuclear and organellar genomes can evolve at vastly different rates despite occupying the same cell. In most bilaterian animals, mitochondrial DNA (mtDNA) evolves faster than nuclear DNA, whereas this trend is generally reversed in plants. However, in some exceptional angiosperm clades, mtDNA substitution rates have increased up to 5,000 - fold compared with closely related lineages. The mechanisms responsible for this acceleration are generally unknown. Because plants rely on homologous recom...
• Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase AI翻译
  作者：Mills, Joshua; Gebhard, L. Johanna; Schubotz, Florence; Shevchenko, Anna; Speth, Daan R.; Liao, Yan; Duggin, Iain G.; Marchfelder, Anita; Erdmann, Susanne
  作者单位：Max Planck Society; University of Bremen; Max Planck Society; Max Planck Society; University of Technology Sydney; Ulm University
  摘要：Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms interact with their extracellular world. EVs are able to traffic a diverse array of molecules across different species and even domains, facilitating numerous functions. In this study, we investigate EV production in Euryarchaeota, using the model organism Haloferax volcanii. We uncover that EVs enclose RNA, with specific transcripts preferentially enriched, including those with regulatory potential, and...
• The reach of reactivation: Effects of consciously triggered versus unconsciously triggered reactivation of associative memory AI翻译
  作者：Tal, Amir; Schechtman, Eitan; Caughran, Bruce; Paller, Ken A.; Davachi, Lila
  作者单位：Columbia University; University of California System; University of California Irvine; University of California System; University of California Irvine; Northwestern University; Nathan Kline Institute for Psychiatric Research
  摘要：Consolidating memories for long - term storage depends on reactivation. Reactivation occurs both consciously, during wakefulness, and unconsciously, during wakefulness and sleep. While considerable work has examined conscious awake and unconscious sleep reactivation, in this study, we directly compare the consequences of conscious and unconscious reactivation during wakefulness. Forty - one participants learned associations consisting of adjective-object-position triads. Objects were clustered...
• Incipient functional SARS-CoV-2 diversification identified through neural network haplotype maps AI翻译
  作者：Delgado, Soledad; Somovilla, Pilar; Ferrer-Orta, Cristina; Martinez-Gonzalez, Brenda; Vazquez-Monteagudo, Sergi; Munoz-Flores, Javier; Soria, Maria Eugenia; Garcia-Crespo, Carlos; de Avila, Ana Isabel; Duran-Pastor, Antoni; Gadea, Ignacio; Lopez-Galindez, Cecilio; Moran, Federico; Lorenzo-Redondo, Ramon; Verdaguer, Nuria; Perales, Celia; Domingo, Esteban
  作者单位：Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa (CBM); Autonomous University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Biologia Molecular de Barcelona (IBMB); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB); Autonomous University of Madrid; Instituto de Salud Carlos III; Centro Nacional de Microbiologia (CNM); Complutense University of Madrid; Northwestern University; Feinberg School of Medicine
  摘要：Since its introduction in the human population, SARS-CoV-2 has evolved into multiple clades, but the events in its intrahost diversification are not well understood. Here, we compare three- dimensional (3D) self- organized neural haplotype maps (SOMs) of SARS-CoV-2 from thirty individual nasopharyngeal diagnostic samples obtained within a 19- day interval in Madrid (Spain), at the time of transition between clades 19 and 20. SOMs have been trained with the haplotype repertoire present in the m...
• Genetic basis and trade-offs of cold acclimation AI翻译
  作者：Yoccoz, Nigel
  作者单位：UiT The Arctic University of Tromso
• Strategy to develop broadly effective multivalent COVID-19 vaccines against emerging variants based on Ad5/35 platform AI翻译
  作者：Chang, Soojeong; Shin, Kwang-Soo; Park, Bongju; Park, Seowoo; Shin, Jieun; Park, Hyemin; Jung, In Kyung; Kim, Jong Heon; Bae, Seong Eun; Kim, Jae- Ouk; Baek, Seung Ho; Kim, Green; Hong, Jung Joo; Seo, Hyungseok; Volz, Erik; Kang, Chang- Yuil
  作者单位：International Vaccine Institute; Korea Research Institute of Bioscience & Biotechnology (KRIBB); Korea Research Institute of Bioscience & Biotechnology (KRIBB); Seoul National University (SNU); Imperial College London
  摘要：The severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) Omicron strain has evolved into highly divergent variants with several sub- lineages. These newly emerging variants threaten the efficacy of available COVID-19 vaccines. To mitigate the occurrence of breakthrough infections and re- infections, and more importantly, to reduce the disease burden, it is essential to develop a strategy for producing updated multivalent vaccines that can provide broad neutralization against both curr...