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作者：Maldarelli, Charles
作者单位：City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System; City College of New York (CUNY)
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作者：Rowley-Conwy, Peter
作者单位：Durham University
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作者：Benedetti, Francesca; Silvestri, Giovannino; Denaro, Frank; Finesso, Giovanni; Contreras-Galindo, Rafael; Munawwar, Arshi; Williams, Sumiko; Davis, Harry; Bryant, Joseph; Wang, Yin; Radaelli, Enrico; Rathinam, Chozha V.; Gallo, Robert C.; Zella, Davide
作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; Morgan State University; University of Pennsylvania; University of Alabama System; University of Alabama Birmingham; University System of Maryland; University of Maryland Baltimore
摘要：Well- controlled repair mechanisms are involved in the maintenance of genomic stability, and their failure can precipitate DNA abnormalities and elevate tumor risk. In addition, the tumor microenvironment, enriched with factors inducing oxidative stress and affecting cell cycle checkpoints, intensifies DNA damage when repair pathways falter. Recent research has unveiled associations between certain bacteria, including Mycoplasmas, and various cancers, and the causative mechanism(s) are under a...
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作者：Kretsch, Rachael C.; Xu, Lily; Zheludev, Ivan N.; Zhou, Xueting; Huang, Rui; Nye, Grace; Li, Shanshan; Zhang, Kaiming; Chiu, Wah; Das, Rhiju
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Howard Hughes Medical Institute; Stanford University
摘要：Coronavirus genomes sequester their start codons within stem - loop 5 (SL5), a structured, 5 ' genomic RNA element. In most alpha- and betacoronaviruses, the secondary structure of SL5 is predicted to contain a four - way junction of helical stems, some of which are capped with UUYYGU hexaloops. Here, using cryogenic electron microscopy (cryo-EM) and computational modeling with biochemically determined secondary structures, we present three- dimensional structures of SL5 from six coronaviruses...
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作者：Huebner, Valentin; Staab, Manuel; Hilbe, Christian; Chatterjee, Krishnendu; Kleshnina, Maria
作者单位：Institute of Science & Technology - Austria; University of Queensland; Max Planck Society
摘要：Direct reciprocity is a powerful mechanism for cooperation in social dilemmas. The very logic of reciprocity, however, seems to require that individuals are symmetric, and that everyone has the same means to influence each others' payoffs. Yet in many applications, individuals are asymmetric. Herein, we study the effect of asymmetry in linear public good games. Individuals may differ in their endowments (their ability to contribute to a public good) and in their productivities (how effective t...
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作者：Ray, Dhiman; Parrinello, Michele
作者单位：Istituto Italiano di Tecnologia - IIT
摘要：Studying the pathways of ligand-receptor binding is essential to understand the mechanism of target recognition by small molecules. The binding free energy and kinetics of protein-ligand complexes can be computed using molecular dynamics (MD) simulations, often in quantitative agreement with experiments. However, only a qualitative picture of the ligand binding/unbinding paths can be obtained through a conventional analysis of the MD trajectories. Besides, the higher degree of manual effort in...
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作者：Saez, Juan C.
作者单位：Universidad de Valparaiso
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作者：Hideshima, Teru; Qi, Jun; Paranal, Ronald M.; Tang, Weiping; Greenberg, Edward; West, Nathan; Colling, Meaghan E.; Estiu, Guillermina; Mazitschek, Ralph; Perry, Jennifer A.; Ohguchi, Hiroto; Cottini, Francesca; Mimura, Naoya; Gorgun, Gullu; Tai, Yu-Tzu; Richardson, Paul G.; Carrasco, Ruben D.; Wiest, Olaf; Schreiber, Stuart L.; Anderson, Kenneth C.; Bradner, James E.
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作者：Waite, Kenrick A.; Vontz, Gabrielle; Lee, Stella Y.; Roelofs, Jeroen
作者单位：Louisiana State University System; Louisiana State University Health Sciences Center New Orleans; University of Kansas; University of Kansas Medical Center
摘要：Stress conditions can cause the relocalization of proteasomes to condensates in yeast and mammalian cells. The interactions that facilitate the formation of proteasome condensates, however, are unclear. Here, we show that the formation of proteasome condensates in yeast depends on ubiquitin chains together with the proteasome shuttle factors Rad23 and Dsk2. These shuttle factors colocalize to these condensates. Strains deleted for the third shuttle factor gene, DDI1, show proteasome condensate...
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作者：Heckmeier, Philipp J.; Ruf, Jeannette; Rochereau, Charlotte; Hamm, Peter
作者单位：University of Zurich; Columbia University
摘要：Protein dynamics form a critical bridge between protein structure and function, yet the impact of evolution on ultrafast processes inside proteins remains enigmatic. This study delves deep into nanosecond -scale protein dynamics of a structurally and functionally conserved protein across species separated by almost a billion years, investigating ten homologs in complex with their ligand. By inducing a photo -triggered destabilization of the ligand inside the binding pocket, we resolved distinc...
