10期

最新文章

• Pyrenoid proteomics reveals independent evolution of the CO2-concentrating organelle in chlorarachniophytes AI翻译
  作者：Moromizato, Rena; Fukuda, Kodai; Suzuki, Shigekatsu; Motomura, Taizo; Nagasato, Chikako; Hirakawa, Yoshihisa
  作者单位：University of Tsukuba; University of Tsukuba; National Institute for Environmental Studies - Japan; Hokkaido University; University of Tsukuba
  摘要：Pyrenoids are microcompartments that are universally found in the photosynthetic plastids of various eukaryotic algae. They contain ribulose-1,5- bisphosphate carboxylase/oxygenase (Rubisco) and play a pivotal role in facilitating CO2 assimilation via CO2- concentrating mechanisms (CCMs). Recent investigations involving model algae have revealed that pyrenoid- associated proteins participate in pyrenoid biogenesis and CCMs. However, these organisms represent only a small part of algal lineages...
• NOVA1 acts as an oncogenic RNA- binding protein to regulate cholesterol homeostasis in human glioblastoma cells AI翻译
  作者：Saito, Yuhki; Yang, Yanhong; Saito, Misa; Park, Christopher Y.; Funato, Kosuke; Tabar, Viviane; Darnell, Robert B.
  作者单位：Howard Hughes Medical Institute; Rockefeller University; Rockefeller University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Simons Foundation; Flatiron Institute; University System of Georgia; University of Georgia
  摘要：NOVA1 is a neuronal RNA- binding protein identified as the target antigen of a rare autoimmune disorder associated with cancer and neurological symptoms, termed paraneoplastic opsoclonus- myoclonus ataxia. Despite the strong association between NOVA1 and cancer, it has been unclear how NOVA1 function might contribute to cancer biology. In this study, we find that NOVA1 acts as an oncogenic factor in a GBM (glioblastoma multiforme) cell line established from a patient. Interestingly, NOVA1 and ...
• The driving force behind tool- stone selection in the African Middle Stone Age AI翻译
  作者：Schmidt, Patrick; Pappas, Ioannis; Porraz, Guillaume; Berthold, Christoph; Nickel, Klaus G.
  作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); University of Witwatersrand; Eberhard Karls University of Tubingen
  摘要：In the Stone Age, the collection of specific rocks was the first step in tool making. Very little is known about the choices made during tool - stone acquisition. Were choices governed by the knowledge of, and need for, specific properties of stones? Or were the collected raw materials a mere by- product of the way people moved through the landscape? We investigate these questions in the Middle Stone Age (MSA) of southern Africa, analyzing the mechanical properties of tool- stones used at the ...
• Membrane localization accelerates association under conditions relevant to cellular signaling AI翻译
  作者：Huang, William Y. C.; Boxer, Steven G.; Ferrell Jr, James E.
  作者单位：Stanford University; Stanford University; Stanford University; Johns Hopkins University
  摘要：Translocation of cytoplasmic molecules to the plasma membrane is commonplace in cell signaling. Membrane localization has been hypothesized to increase intermolecular association rates; however, it has also been argued that association should be faster in the cytosol because membrane diffusion is slow. Here, we directly compare an identical association reaction, the binding of complementary DNA strands, in solution and on supported membranes. The measured rate constants show that for a 10-mu m...
• Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes AI翻译
  作者：Tassoulas, Lambros J.; Rankin, Joel A.; Elias, Mikael H.; Wackett, Lawrence P.; Rosenzweig, Amy
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Metformin is the first - line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally and entering wastewater. The drug's direct mode of action is currently unknown but is linked to effects on gut microbiomes and may involve specific gut microbial reactions to the drug. In wastewater treatment plants, metformin is known to be transformed by microbes to guanylurea, although genes encoding this metabolism had not been elucidated. In the p...
• A simple, statistically robust test of discrimination AI翻译
  作者：Gaebler, Johann D.; Goel, Sharad
  作者单位：Harvard University; Harvard University
  摘要：In observational studies of discrimination, the most common statistical approaches consider either the rate at which decisions are made (benchmark tests) or the success rate of those decisions (outcome tests). Both tests, however, have well-known statistical limitations, sometimes suggesting discrimination even when there is none. Despite the fallibility of the benchmark and outcome tests individually, here we prove a surprisingly strong statistical guarantee: Under a common nonparametric assu...
• Real- time imaging of standing- wave patterns in microresonators AI翻译
  作者：Yan, Haochen; Ghosh, Alekhya; Pal, Arghadeep; Zhang, Hao; Bi, Toby; Ghalanos, George; Zhang, Shuangyou; Hill, Lewis; Zhang, Yaojing; Zhuang, Yongyong; Xavier, Jolly; Del'Haye, Pascal
  作者单位：Max Planck Society; University of Erlangen Nuremberg; University of Strathclyde; Xi'an Jiaotong University; Xi'an Jiaotong University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi
  摘要：Real - time characterization of microresonator dynamics is important for many applications. In particular, it is critical for near - field sensing and understanding light-matter interactions. Here, we report camera- facilitated imaging and analysis of standing wave patterns in optical ring resonators. The standing wave pattern is generated through bidirectional pumping of a microresonator, and the scattered light from the microresonator is collected by a short - wave infrared (SWIR) camera. Th...
• Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis AI翻译
  作者：Oami, Takehiko; Abtahi, Shabnam; Shimazui, Takashi; Chen, Ching - Wen; Sweat, Yan Y.; Liang, Zhe; Burd, Eileen M.; Farris, Alton B.; Roland, Joe T.; Tsukita, Sachiko; Ford, Mandy L.; Turner, Jerrold R.; Coopersmith, Craig M.
  作者单位：Emory University; Emory University; Chiba University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Emory University; Vanderbilt University; Teikyo University; Emory University
  摘要：Intestinal epithelial expression of the tight junction protein claudin- 2, which forms paracellular cation and water channels, is precisely regulated during development and in disease. Here, we show that small intestinal epithelial claudin- 2 expression is selectively upregulated in septic patients. Similar changes occurred in septic mice, where claudin- 2 upregulation coincided with increased flux across the paracellular pore pathway. In order to define the significance of these changes, seps...
• Single- cell profiling of African swine fever virus disease in the pig spleen reveals viral and host dynamics AI翻译
  作者：Zhu, Zixiang; Mao, Ruoqing; Liu, Baohong; Liu, Huanan; Shi, Zhengwang; Zhang, Kunpeng; Liu, Huisheng; Zhang, Danyang; Liu, Jia; Zhao, Zhenxiang; Li, Kangli; Yang, Fan; Cao, Weijun; Zhang, Xiangle; Shen, Chaochao; Sun, Dehui; Wang, Liyuan; Tian, Hong; Ru, Yi; Feng, Tao; He, Jijun; Guo, Jianhong; Zhang, Keshan; Tang, Zhonglin; Zhang, Shilei; Ding, Chan; Han, Jun; Zheng, Haixue
  作者单位：Lanzhou University; Chinese Academy of Agricultural Sciences; Lanzhou Veterinary Research Institute, CAAS; Chinese Academy of Agricultural Sciences; Lanzhou Veterinary Research Institute, CAAS; Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Chinese Academy of Agricultural Sciences; Shanghai Veterinary Research Institute, CAAS; China Agricultural University
  摘要：African swine fever, one of the major viral diseases of swine, poses an imminent threat to the global pig industry. The high - efficient replication of the causative agent African swine fever virus (ASFV) in various organs in pigs greatly contributes to the disease. However, how ASFV manipulates the cell population to drive high - efficient replication of the virus in vivo remains unclear. Here, we found that the spleen reveals the most severe pathological manifestation with the highest viral ...
• Human transferrin receptor can mediate SARS-CoV-2 infection AI翻译
  作者：Liao, Zhiyi; Wang, Chaoming; Tang, Xiaopeng; Yang, Mengli; Duan, Zilei; Liu, Lei; Lu, Shuaiyao; Ma, Lei; Cheng, Ruomei; Wang, Gan; Liu, Hongqi; Yang, Shuo; Xu, Jingwen; Tadese, Dawit Adisu; Mwangi, James; Kamau, Peter Muiruri; Zhang, Zhiye; Yang, Lian; Liao, Guoyang; Zhao, Xudong; Peng, Xiaozhong; Lai, Ren
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Qingdao University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Medical Biology - CAMS; Sichuan University; Chinese Academy of Sciences; Kunming Institute of Botany, CAS
  摘要：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been detected in almost all organs of coronavirus disease-19 patients, although some organs do not express angiotensin-converting enzyme-2 (ACE2), a known receptor of SARS-CoV-2, implying the presence of alternative receptors and/or co-receptors. Here, we show that the ubiquitously distributed human transferrin receptor (TfR), which binds to diferric transferrin to traffic between membrane and endosome for the iron deli...