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作者：[Anonymous]
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作者：Brownfield, Bryce A.; Richardson, Brian C.; Halaby, Steve L.; Fromme, J. Christopher
作者单位：Cornell University; Cornell University; University of Minnesota System; AbbVie
摘要：The late stages of Golgi maturation involve a series of sequential trafficking events in which cargo - laden vesicles are produced and targeted to multiple distinct subcellular destinations. Each of these vesicle biogenesis events requires activation of an Arf GTPase by the Sec7/BIG guanine nucleotide exchange factor (GEF). Sec7 localization and activity is regulated by autoinhibition, positive feedback, and interaction with other GTPases. Although these mechanisms have been characterized bioc...
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作者：Tan, Jue Yu Kelly; Chew, Liang Yuh; Juhasz, Gabor; Yu, Fengwei
作者单位：National University of Singapore; National University of Singapore; Eotvos Lorand University; HUN-REN; HUN-REN Biological Research Center; Institute of Genetics - HAS
摘要：Autophagy is essential for the turnover of damaged organelles and long - lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental and neurodegenerative diseases in humans. However, the role of autophagy in neuronal pruning during development remains poorly understood. Here, we report that autophagy regulates dendrite- specific pruning of ddaC sensory neurons in parallel to local caspa...
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作者：Schwartzman, Julia A.; Lebreton, Francois; Salamzade, Rauf; Shea, Terrance; Martin, Melissa J.; Schaufler, Katharina; Urhan, Aysun; Abeel, Thomas; Camargo, Ilana L. B. C.; Sgardioli, Bruna F.; Prichula, Janira; Frazzon, Ana Paula Guedes; Giribet, Gonzalo; Van Tyne, Daria; Treinish, Gregg; Innis, Charles J.; Wagenaar, Jaap A.; Whipple, Ryan M.; Manson, Abigail L.; Earl, Ashlee M.; Gilmore, Michael S.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Southern California; Walter Reed Army Institute of Research (WRAIR); United States Department of Defense; United States Army; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Wisconsin System; University of Wisconsin Madison; Universitat Greifswald; University of Kiel; Schleswig Holstein University Hospital; University of Kiel; Delft University of Technology; Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul; Harvard University; Harvard University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Utrecht University
摘要：Enterococci are gut microbes of most land animals. Likely appearing first in the guts of arthropods as they moved onto land, they diversified over hundreds of millions of years adapting to evolving hosts and host diets. Over 60 enterococcal species are now known. Two species, Enterococcus faecalis and Enterococcus faecium, are common constituents of the human microbiome. They are also now leading causes of multidrug- resistant hospital- associated infection. The basis for host association of e...
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作者：Wang, Guangrong; Li, Jianbiao; Wang, Wenhua; Niu, Xiaofei; Wang, Yue; Selten, Reinhard
作者单位：Weifang University; Shandong University; Nankai University
摘要：Some scholars find that behavioral variation in the public goods game is explained by variations in participants' understanding of how to maximize payoff and that confusion leads to cooperation. Their findings lead them to question the common assumption in behavioral economics experiments that choices reflect motivations. We conduct two experiments, in which we minimize confusion by providing participants with increased training. We also introduce a question that specifically assesses particip...
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作者：Fuggetta, Nicolas; Rigolli, Nicola; Magdeleine, Maud; Hamai, Amazigh; Seminara, Agnese; Drin, Guillaume
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Universite Paris Cite; University of Genoa
摘要：Oxysterol- binding protein- related proteins (ORPs) play key roles in the distribution of lipids in eukaryotic cells by exchanging sterol or phosphatidylserine for PI4P between the endoplasmic reticulum (ER) and other cell regions. However, it is unclear how their exchange capacity is coupled to PI4P metabolism. To address this question quantitatively, we analyze the activity of a representative ORP, Osh4p, in an ER/Golgi interface reconstituted with ER- and Golgi- mimetic membranes functional...
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作者：Ma, Rong; Sun, Eric D.; Donoho, David; Zou, James
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Stanford University; Stanford University
摘要：Single-cell data integration can provide a comprehensive molecular view of cells, and many algorithms have been developed to remove unwanted technical or biological variations and integrate heterogeneous single-cell datasets. Despite their wide usage, existing methods suffer from several fundamental limitations. In particular, we lack a rigorous statistical test for whether two high-dimensional single-cell datasets are alignable (and therefore should even be aligned). Moreover, popular methods...
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作者：Meng, Juanjuan
作者单位：Peking University
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作者：Shain, Cory; Meister, Clara; Pimentel, Tiago; Cotterell, Ryan; Levy, Roger
作者单位：Massachusetts Institute of Technology (MIT); Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge
摘要：During real-time language comprehension, our minds rapidly decode complex meanings from sequences of words. The difficulty of doing so is known to be related to words' contextual predictability, but what cognitive processes do these predictability effects reflect? In one view, predictability effects reflect facilitation due to anticipatory processing of words that are predictable from context. This view predicts a linear effect of predictability on processing demand. In another view, predictab...
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作者：Zhu, Ziheng; Chen, Shi; Zhang, Chongyu; Lu, Xi; Zhang, Xiliang; Zhang, Xiaoye; Davidson, Michael R.
作者单位：Tsinghua University; Tsinghua University; China Meteorological Administration; Chinese Academy of Meteorological Sciences (CAMS); University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：China has committed to achieve net carbon neutrality by 2060 to combat global climate change, which will require unprecedented deployment of negative emissions technologies, renewable energies (RE), and complementary infrastructure. At terawattscale deployment, land use limitations interact with operational and economic features of power systems. To address this, we developed a spatially resolved resource assessment and power systems planning optimization that models a full year of power syste...
