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• Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells AI翻译
  作者：Jiang, Yu; Huang, Haidi; Liu, Jiangying; Luo, Dan; Mu, Rongzi; Yuan, Jianghong; Lin, Jihong; Chen, Qiyue; Tao, Wufan; Yang, Ling; Zhang, Man; Zhang, Pingping; Fang, Fengqin; Xu, Jianming; Gong, Qingqiu; Xie, Zhiping; Zhang, Yongchun
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fujian Medical University; Fujian Medical University; Fujian Medical University; Fudan University; Fudan University; Inner Mongolia Medical University; Inner Mongolia Medical University; Guangzhou Medical University; Shanghai Jiao Tong University; Baylor College of Medicine
  摘要：Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of the epithelium of the foregut, including the esophagus and the forestomach. Aberrant genetic regulation in these cells can lead to carcinogenesis, such as squamous cell carcinoma (SCC). However, the underlying molecular mechanisms regulating the function of basal progenitor cells remain largely unknown. Here, we use mouse models to reveal that Hippo signaling is required for maintaining the homeostasis of the foreg...
• The distorting effects of producer strategies: Why engagement does not reveal consumer preferences for misinformation AI翻译
  作者：Stewart, Alexander J.; Arechar, Antonio A.; Rand, David G.; Plotkin, Joshua B.
  作者单位：University of St Andrews; Centro de Investigacion y Docencia Economicas A.C. (CIDE); Massachusetts Institute of Technology (MIT); University of Pennsylvania
  摘要：A great deal of empirical research has examined who falls for misinformation and why. Here, we introduce a formal game -theoretic model of engagement with news stories that captures the strategic interplay between (mis)information consumers and producers. A key insight from the model is that observed patterns of engagement do not necessarily reflect the preferences of consumers. This is because producers seeking to promote misinformation can use strategies that lead moderately inattentive read...
• Magnetochiral tunneling in paramagnetic Co1/3NbS2 AI翻译
  作者：Lim, Seongjoon; Singh, Sobhit; Huang, Fei-Ting; Pan, Shangke; Wang, Kefeng; Kim, Jaewook; Kim, Jinwoong; Vanderbilt, David; Cheong, Sang-Wook
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University of Rochester; University of Rochester; Ningbo University
  摘要：Electric currents have the intriguing ability to induce magnetization in nonmagnetic crystals with sufficiently low crystallographic symmetry. Some associated phenomena include the non - linear anomalous Hall effect in polar crystals and the nonreciprocal directional dichroism in chiral crystals when magnetic fields are applied. In this work, we demonstrate that the same underlying physics is also manifested in the electronic tunneling process between the surface of a nonmagnetic chiral materi...
• 撤稿声明: Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling (Retraction of Vol 109, Pg E841, 2012) AI翻译
  作者：Steenbergen, Charles; Dietz, Harry C.; Semenza, Gregg L.
• Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage AI翻译
  作者：Jain, Akansha; Kim, Bo Ram; Yu, Wenjie; Moninger, Thomas O.; Karp, Philip H.; Wagner, Brett A.; Welsh, Michael J.
  作者单位：University of Iowa; University of Iowa; Howard Hughes Medical Institute; University of Iowa; University of Iowa
  摘要：Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely grouping mitochondria just beneath the apical membrane. However, this efficient localization comes at a cost because electrons leaked during oxidative phosphorylation react with molecular oxygen to form superoxide, and thus, the cluster of mitochondria creates a hotspot for oxidant production. The relatively hi...
• A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human AI翻译
  作者：Liu, Yakun; Fan, Hongwei; Kang, Xi; Hao, Yuntao; Wang, Na; Zheng, Hui; Li, Yan; Kang, Shan
  作者单位：Hebei Medical University; Hebei Medical University; Hebei Medical University
  摘要：Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ cells that mainly occur during the first 30 y of a female's life. Early age of onset strongly suggests the presence of susceptibility gene mutations for the disease yet to be discovered. Whole exon sequencing was used to screen pathogenic mutations from pedigrees with OITs. A rare missense germline mutation (C262T) in the first exon of the BMP15 gene was identified. In silico calculation suggested that the...
• The ALOG domain defines a family of plant- specific transcription factors acting during Arabidopsis flower development AI翻译
  作者：Rieu, Philippe; Beretta, Veronica Maria; Caselli, Francesca; Thevenon, Emmanuel; Lucas, Jeremy; Rizk, Mahmoud; Franchini, Emanuela; Caporali, Elisabetta; Paleni, Chiara; Nanao, Max H.; Kater, Martin M.; Dumas, Renaud; Zubieta, Chloe; Parcy, Francois; Gregis, Veronica
  作者单位：University of Geneva; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); University of Milan; European Synchrotron Radiation Facility (ESRF)
  摘要：The ALOG (Arabidopsis LIGHT- DEPENDENT SHORT HYPOCOTYLS 1 (LSH1) and Oryza G1) proteins are conserved plant- specific Transcription Factors (TFs). They play critical roles in the development of various plant organs (meristems, inflorescences, floral organs, and nodules) from bryophytes to higher flowering plants. Despite the fact that the first members of this family were originally discovered in Arabidopsis, their role in this model plant has remained poorly characterized. Moreover, how these...
• Modeling neurodevelopmental disorder- associated human AGO1 mutations in Caenorhabditis elegans Argonaute alg-1 AI翻译
  作者：Duan, Ye; Li, Li; Panzade, Ganesh Prabhakar; Piton, Amelie; Zinovyeva, Anna; Ambros, Victor
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Harvard University; Kansas State University; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
  摘要：MicroRNAs (miRNA) associate with Argonaute (AGO) proteins and repress gene expression by base pairing to sequences in the 3 ' untranslated regions of target genes. De novo coding variants in the human AGO genes AGO1 and AGO2 cause neurodevelopmental disorders (NDD) with intellectual disability, referred to as Argonaute syndromes. Most of the altered amino acids are conserved between the miRNA- associated AGO in Homo sapiens and Caenorhabditis elegans, suggesting that the human mutations could ...
• Variable carbon isotope fractionation of photosynthetic communities over depth in an open- ocean euphotic zone AI翻译
  作者：Henderson, Lillian C.; Wittmers, Fabian; Carlson, Craig A.; Worden, Alexandra Z.; Close, Hilary G.
  作者单位：University of Miami; Marine Biological Laboratory - Woods Hole; University of Kiel; University of California System; University of California Santa Barbara
  摘要：Marine particulate organic carbon (POC) contributes to carbon export, food webs, and sediments, but uncertainties remain in its origins. Globally, variations in stable carbon isotope ratios (delta 13C values) of POC between the upper and lower euphotic zones (LEZ) indicate either varying aspects of photosynthetic communities or degradative alteration of POC. During summertime in the subtropical north Atlantic Ocean, we find that delta 13C values of the photosynthetic product phytol decreased b...
• An evolutionary innovation for mating facilitates ecological niche expansion and buffers species against climate change AI翻译
  作者：Moore, Michael P.; Nalley, Sarah E.; Hamadah, Dalal
  作者单位：University of Colorado System; University of Colorado Denver; University of Colorado Anschutz Medical Campus; Children's Hospital Colorado; Washington University (WUSTL)
  摘要：One of the drivers of life's diversification has been the emergence of evolutionary innovations: The evolution of traits that grant access to underused ecological niches. Since ecological interactions can occur separately from mating, mating-related traits have not traditionally been considered factors in niche evolution. However, in order to persist in their environment, animals need to successfully mate just as much as they need to survive. Innovations that facilitate mating activity may the...