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最新文章

• Unique insights into the design of low- strain single- crystalline Ni- rich cathodes with superior cycling stability AI翻译
  作者：Han, Qiang; Yu, Haifeng; Cai, Lele; Chen, Ling; Li, Chunzhong; Jiang, Hao
  作者单位：East China University of Science & Technology; East China University of Science & Technology
  摘要：Micro- sized single- crystalline Ni- rich cathodes are emerging as prominent candidates owing to their larger compact density and higher safety compared with poly- crystalline counterparts, yet the uneven stress distribution and lattice oxygen loss result in the intragranular crack generation and planar gliding. Herein, taking LiNi0.83Co0.12Mn0.05O2 as an example, an optimal particle size of 3.7 mu m is predicted by simulating the stress distributions at various states of charge and their rela...
• Deficiency of factor- inhibiting HIF creates a tumor- promoting immune microenvironment AI翻译
  作者：Ma, Jingyi; Al Moussawi, Khatoun; Lou, Hantao; Chan, Hok Fung; Wang, Yihua; Chadwick, Joseph; Phetsouphanh, Chansavath; Slee, Elizabeth A.; Zhong, Shan; Leissing, Thomas M.; Roth, Andrew; Qin, Xiao; Chen, Shuo; Yin, Jie; Ratnayaka, Indrika; Hu, Yang; Louphrasitthiphol, Pakavarin; Taylor, Lewis; Bettencourt, Paulo J. G.; Muers, Mary; Greaves, David R.; Mcshane, Helen; Goldin, Robert; Soilleux, Elizabeth J.; Coleman, Mathew L.; Ratcliffe, Peter J.; Lu, Xin
  作者单位：Ludwig Institute for Cancer Research; University of Oxford; University of Southampton; University of New South Wales Sydney; Kirby Institute; British Columbia Cancer Agency; University of British Columbia; University of British Columbia; University of London; University College London; University of Oxford; University of Oxford; Jenner Institute; Universidade de Lisboa; Universidade Catolica Portuguesa; Imperial College London; University of Cambridge; University of Birmingham
  摘要：Hypoxia signaling influences tumor development through both cell- intrinsic and - extrinsic pathways. Inhibiting hypoxia- inducible factor (HIF) function has recently been approved as a cancer treatment strategy. Hence, it is important to understand how regulators of HIF may affect tumor growth under physiological conditions. Here we report that in aging mice factor- inhibiting HIF (FIH), one of the most studied negative regulators of HIF, is a haploinsufficient suppressor of spontaneous B cel...
• Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip- link stability AI翻译
  作者：Li, Nana; Liu, Shuang; Zhao, Dange; Du, Haibo; Xi, Yuehui; Wei, Xiaoxi; Mueller, Ulrich; Liu, Qingling; Lu, Qing; Xiong, Wei; Nathans, Jeremy; Xu, Zhigang
  作者单位：Shandong University; Shandong University; Chinese Institute for Brain Research, Beijing; Shanghai Jiao Tong University; Johns Hopkins University; Shandong Normal University
  摘要：Inner ear hair cells are characterized by the F- actin-based stereocilia that are arranged into a staircase-like pattern on the apical surface of each hair cell. The tips of shorter-row stereocilia are connected with the shafts of their neighboring taller-row stereocilia through extracellular links named tip links, which gate mechano- electrical transduction (MET) channels in hair cells. Cadherin 23 (CDH23) forms the upper part of tip links, and its cytoplasmic tail is inserted into the so-cal...
• Optimizing non-Newtonian fluids for impact protection of laminates AI翻译
  作者：Richards, James A.; Hodgson, Daniel J. M.; O'Neill, Rory E.; Derosa, Michael E.; Poon, Wilson C. K.
  作者单位：University of Edinburgh; State University of New York (SUNY) System; SUNY Community College; Corning Inc
  摘要：Non -Newtonian fluids can be used for the protection of flexible laminates. Understanding the coupling between the flow of the protecting fluid and the deformation of the protected solids is necessary in order to optimize this functionality. We present a scaling analysis of the problem based on a single coupling variable, the effective width of a squeeze flow between flat rigid plates, and predict that impact protection for laminates is optimized by using shear -thinning, and not shear -thicke...
• Three- atom- wide gold quantum rods with periodic elongation and strongly polarized excitons AI翻译
  作者：Luo, Lianshun; Liu, Zhongyu; Kong, Jie; Gianopoulos, Christopher G.; Coburn, Isabelle; Kirschbaum, Kristin; Zhou, Meng; Jin, Rongchao
  作者单位：Carnegie Mellon University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University System of Ohio; University of Toledo
  摘要：Atomically precise control over anisotropic nanoclusters constitutes a grand challenge in nanoscience. In this work, we report our success in achieving a periodic series of atomically precise gold quantum rods (abbrev. Au QRs) with unusual excitonic properties. These QRs possess hexagonal close- packed kernels with a constant three- atom diameter but increasing aspect ratios (ARs) from 6.3 to 18.7, all being protected by the same thiolate (SR) ligand. The kernels of the QRs are in a Au1-(Au3)n...
• Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation AI翻译
  作者：El Mammeri, Nadia; Dregni, Aurelio J.; Duan, Pu; Hong, Mei
  作者单位：Massachusetts Institute of Technology (MIT)
  摘要：The microtubule- associated protein tau aggregates into amyloid fibrils in Alzheimer's disease and other neurodegenerative diseases. In these tauopathies, tau is hyperphosphorylated, suggesting that this posttranslational modification (PTM) may induce tau aggregation. Tau is also phosphorylated in normal developing brains. To investigate how tau phosphorylation induces amyloid fibrils, here we report the atomic structures of two phosphomimetic full- length tau fibrils assembled without anionic...
• Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress AI翻译
  作者：Eldeeb, Mohamed A.; Bayne, Andrew N.; Fallahi, Armaan; Goiran, Thomas; Macdougall, Emma J.; Soumbasis, Andrea; Zorca, Cornelia E.; Tabah, Jace-Jones; Thomas, Rhalena A.; Karpilovsky, Nathan; Mathur, Meghna; Durcan, Thomas M.; Trempe, Jean-Francois; Fon, Edward A.
  作者单位：McGill University; McGill University; McGill University; McGill University
  摘要：Mutations in PTEN- induced putative kinase 1 (PINK1) cause autosomal recessive early - onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial quality control by triggering mitophagy mediated by the ubiquitin (Ub) ligase Parkin. Upon mitochondrial damage, PINK1 accumulates on the outer mitochondrial membrane forming a high- molecular- weight complex with the translocase of the outer membrane (TOM). PINK1 then phosphorylates Ub, which enables recruitment and activ...
• Host- encoded CTCF regulates human cytomegalovirus latency via chromatin looping AI翻译
  作者：Groves, Ian J.; Matthews, Stephen M.; O'Connor, Christine M.
  作者单位：Cleveland Clinic Foundation; Cleveland Clinic Foundation; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University
  摘要：Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes life - long latent infection in hematopoietic cells. While this infection is usually asymptomatic, immune dysregulation leads to viral reactivation, which can cause significant morbidity and mortality. However, the mechanisms underpinning reactivation remain incompletely understood. The HCMV major immediate early promoter (MIEP)/enhancer is a key factor in this process, as its transactivation from a repressed to active state...
• Absolute energy levels of liquid water from many-body perturbation theory with effective vertex corrections AI翻译
  作者：Tal, Alexey; Bischoff, Thomas; Pasquarello, Alfredo
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：We demonstrate the importance of addressing the F vertex and thus going beyond the GW approximation for achieving the energy levels of liquid water in manybody perturbation theory. In particular, we consider an effective vertex function in both the polarizability and the self -energy, which does not produce any computational overhead compared with the GW approximation. We yield the band gap, the ionization potential, and the electron affinity in good agreement with experiment and with a hybrid...
• Genomic ancestry and social dynamics of the last hunter- gatherers of Atlantic France AI翻译
  作者：Simoes, Luciana G.; Stjerna, Rita Peyroteo-; Marchand, Gregor; Bernhardsson, Carolina; Vialet, Amelie; Chetty, Darshan; Alacamli, Erkin; Edlund, Hanna; Bouquin, Denis; Dina, Christian; Garmond, Nicolas; Gunther, Torsten; Jakobsson, Mattias
  作者单位：Uppsala University; University of Gothenburg; Linnaeus University; Universidade de Lisboa; Centre National de la Recherche Scientifique (CNRS); Universite de Rennes; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Texas A&M University System; Texas A&M University College Station; Universite Bourgogne Europe; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Nantes Universite; CHU de Nantes; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS)
  摘要：Since the early Holocene, western and central Europe was inhabited by a genetically distinct group of Western Hunter- Gatherers (WHGs). This group was eventually replaced and assimilated by the incoming Neolithic farmers. The western Atlantic fa & ccedil;ade was home to some of the last Mesolithic sites of mainland Europe, represented by the iconic open - air sites at Hoedic and T & eacute;viec in southern Brittany, France. These sites are known for the unusually well- preserved and rich buria...