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作者：Gao, Jingxia; Skidmorea, Jennifer M.; Cimermana, Jelka; Ritter, K. Elaine; Qiu, Jingyun; Wilsond, Lindsey M. Q.; Raphaele, Yehoash; Kwanb, Kelvin Y.; Martin, Donna M.
作者单位：St Jude Children's Research Hospital; University of Michigan System; University of Michigan; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Inner ear morphogenesis requires tightly regulated epigenetic and transcriptional control of gene expression. CHD7, an ATP- dependent chromodomain helicase DNA- binding protein, and SOX2, an SRY- related HMG box pioneer transcription factor, are known to contribute to vestibular and auditory system development, but their genetic interactions in the ear have not been explored. Here, we analyzed inner ear development and the transcriptional regulatory landscapes in mice with variable dosages of ...
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作者：Katsumura, Koichi R.; Liu, Peng; Kim, Jeong-ah; Mehta, Charu; Bresnick, Emery H.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Mutations in genes encoding transcription factors inactivate or generate ectopic activities to instigate pathogenesis. By disrupting hematopoietic stem/progenitor cells, GATA2 germline variants create a bone marrow failure and leukemia predisposition, GATA2 deficiency syndrome, yet mechanisms underlying the complex phenotypic constellation are unresolved. We used a GATA2- deficient progenitor rescue system to analyze how genetic variation influences GATA2 functions. Pathogenic variants impaire...
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作者：Li, Jian-Feng; Cheng, Wen-Yan; Lin, Xiang-Jie; Wen, Li-Jun; Wang, Kai; Zhu, Yong-Mei; Zhu, Hong-Ming; Chen, Xin-Jie; Zhang, Yu-Liang; Yin, Wei; Zhang, Jia-Nan; Yi, Xiao; Zhang, Fan; Weng, Xiang-Qin; Wang, Sheng-Yue; Jiang, Lu; Wu, Hui-Yi; Ren, Jia-Qi; Lin, Xiao-Jing; Qiao, Niu; Dai, Yu-Ting; Fang, Hai; Tan, Yun; Sun, Xiao-Jian; Lv, Gang; Yan, Xiao-Yu; Chen, Su-Ning; Chen, Zhu; Jin, Jie; Wu, De-Pei; Ren, Rui-Bao; Chen, Sai-Juan; Shen, Yang
作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; Zhejiang University; Soochow University - China; Soochow University - China; Hainan Medical University; Zhejiang University
摘要：Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and targeted or whole exome sequencing data were obtained in 94% cases. The correlation of aging- related factors including age and clonal hematopoiesis (CH), gender, and genomic/transcriptomic profiles (gene fusions, genetic mutations, and gene expression networks or pathways) was systematically analyz...
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作者：Kim, Do-Hyoung; Janga, Yong-Hoon; Yun, Minsik; Lee, Kang-Min; Kim, Young-Joon
作者单位：Gwangju Institute of Science & Technology (GIST)
摘要：Connectomics research has made it more feasible to explore how neural circuits can generate multiple outputs. Female sexual drive provides a good model for understanding reversible, long-term functional changes in motivational circuits. After emerging, female flies avoid male courtship, but they become sexually receptive over 2 d. Mating causes females to reject further mating for several days. Here, we report that pC1 neurons, which process male courtship and regulate copulation behavior, exh...
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作者：Pendharkar, Mihir; Tran, Steven J.; Zaborski, Gregory, Jr.; Finney, Joe; Sharpe, Aaron L.; Kamat, Rupini V.; Kalantre, Sandesh S.; Hocking, Marisa; Bittner, Nathan J.; Watanabe, Kenji; Taniguchi, Takashi; Pittenger, Bede; Newcomb, Christina J.; Kastner, Marc A.; Mannix, Andrew J.; Goldhaber-Gordon, David
作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; United States Department of Energy (DOE); Sandia National Laboratories; National Institute for Materials Science; National Institute for Materials Science; Stanford University; Massachusetts Institute of Technology (MIT)
摘要：In a stack of atomically thin van der Waals layers, introducing interlayer twist creates a moir & eacute; superlattice whose period is a function of twist angle. Changes in that twist angle of even hundredths of a degree can dramatically transform the system's electronic properties. Setting a precise and uniform twist angle for a stack remains difficult; hence, determining that twist angle and mapping its spatial variation is very important. Techniques have emerged to do this by imaging the mo...
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作者：Gor, Gennady Y.; Scherer, George W.; Stone, Howard A.
作者单位：New Jersey Institute of Technology; Princeton University; Princeton University
摘要：Bacterial spores have outstanding properties from the materials science perspective, which allow them to survive extreme environmental conditions. Recent work by [S. G. Harrellson et al., Nature 619, 500-505 (2023)] studied the mechanical properties of Bacillus subtilis spores and the evolution of these properties with the change of humidity. The experimental measurements were interpreted assuming that the spores behave as water -filled porous solids, subjected to hydration forces. Here, we re...
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作者：Trosta, Wiebke; Trevora, Caitlyn; Fernandeza, Natalia; Steinera, Florence; Fruehholza, Sascha
作者单位：University of Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Oslo
摘要：Music is powerful in conveying emotions and triggering affective brain mechanisms. Affective brain responses in previous studies were however rather inconsistent, potentially because of the non- adaptive nature of recorded music used so far. Live music instead can be dynamic and adaptive and is often modulated in response to audience feedback to maximize emotional responses in listeners. Here, we introduce a setup for studying emotional responses to live music in a closed - loop neurofeedback ...
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作者：Twomey, Colin R.; Brainard, David H.; Plotkin, Joshua B.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Color naming in natural languages is not arbitrary: It reflects efficient partitions of 104, 1436-1441 (2007)] modulated by the relative needs to communicate about Sci. U.S.A. 118, e2109237118 (2021)]. These psychophysical and communicative constraints help explain why languages around the world have remarkably similar, but not identical, mappings of colors to color terms. Languages converge on a small set of efficient representations.But languages also evolve, and the number of terms in a col...
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作者：Karimi, Nisa; Krieg, Christopher P.; Spalink, Daniel; Lemmon, Alan R.; Lemmon, Emily Moriarty; Eifler, Evan; Hernandez, Adriana I.; Chan, Patricia W.; Landis, Jacob B.; Strickler, Susan R.; Rodriguez, Aaron; Specht, Chelsea D.; Givnish, Thomas J.
作者单位：Missouri Botanical Gardens; University of Wisconsin System; University of Wisconsin Madison; Texas A&M University System; Texas A&M University College Station; State University System of Florida; Florida State University; State University System of Florida; Florida State University; Cornell University; Cornell University; Universidad de Guadalajara; Cornell University; Boyce Thompson Institute for Plant Research
摘要：We used nuclear genomic data and statistical models to evaluate the ecological and evolutionary processes shaping spatial variation in species richness in Calochortus (Liliaceae, 74 spp.). Calochortus occupies diverse habitats in the western United States and Mexico and has a center of diversity in the California Floristic Province, marked by multiple orogenies, winter rainfall, and highly divergent climates and substrates (including serpentine). We used sequences of 294 low-copy nuclear loci ...
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作者：Young, Paul G.; Levring, Jesper; Fiedorczuk, Karol; Blanchard, Scott C.; Chen, Jue
作者单位：Rockefeller University; St Jude Children's Research Hospital; Rockefeller University; Howard Hughes Medical Institute
摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates electrolyte and fluid balance in epithelial tissues. While activation of CFTR is vital to treating cystic fibrosis, selective inhibition of CFTR is a potential therapeutic strategy for secretory diarrhea and autosomal dominant polycystic kidney disease. Although several CFTR inhibitors have been developed by high- throughput screening, their modes of action remain elusive. In this study, we determ...
