A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

• 成果类型: Article
• 署名作者: Kim, Jihye; Bury, Matthew I.; Kwon, Kyeongha; Yoo, Jae - Young; Halstead, Nadia, V; Shin, Hee-Sup; Li, Shupeng; Won, Sang Min; Seo, Min-Ho; Wu, Yunyun; Park, Do Yun; Kini, Mitali; Kwak, Jean Won; Madhvapathy, Surabhi R.; Ciatti, Joanna L.; Lee, Jae Hee; Kim, Suyeon; Ryu, Hanjun; Yamagishi, Kento; Yoon, Hong- Joon; Kwak, Sung Soo; Kim, Bosung; Huang, Yonggang; Halliday, Lisa C.; Cheng, Earl Y.; Ameer, Guillermo A.; Sharma, Arun K.; Rogers, John A.
• 署名单位: Northwestern University; Sungkyunkwan University (SKKU); Ann & Robert H. Lurie Children's Hospital of Chicago; Korea Advanced Institute of Science & Technology (KAIST); Sungkyunkwan University (SKKU); Northwestern University; Sungkyunkwan University (SKKU); Pusan National University; Northwestern University; Feinberg School of Medicine; Chung Ang University; Gachon University; Korea Institute of Science & Technology (KIST); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15399
• DOI: 10.1073/pnas.2400868121
• 发表日期: 2024-04-02
• 关键词: partial cystectomy; cancer

摘要

Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient - friendly, they exhibit user - to - user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter - associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high - risk patients. Here, we introduce a fully bladder - implantable platform that allows for continuous, real - time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real - time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long - term postoperative bladder recovery monitoring.