Photo- neuro- immuno- endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system

• 成果类型: Article
• 署名作者: Slominski, Radomir M.; Chen, Jake Y.; Raman, Chander; Slominski, Andrzej T.
• 署名单位: University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; US Department of Veterans Affairs; Veterans Health Administration (VHA)
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-13501
• DOI: 10.1073/pnas.2308374121
• 发表日期: 2024-04-02
• 关键词: pituitary-adrenal axis; platelet-activating-factor; vitamin-d; human skin; nitric-oxide; clock genes; b radiation; metabolism; receptor; light

摘要

we have gathered experimental and obser- vational evidence that UVR spectra of solar radiation have profound effects on systemic body homeostasis, which are defined by their wavelength and energy, nature of chromo- phores and of molecules produced in the barrier organ. Local physicochemical changes induced by solar radiation can lead to activation of local neuro- immuno- endocrine sensing and regulatory mechanisms with their projection to the central or systemic levels. While the precise mecha- nisms of these interactions remain to be explored, their health benefits and therapeutic implications can outweigh the negative effects if responsibly applied in an educated manner.