16期

最新文章

• Molecular mechanism underlying SNARE- mediated membrane fusion enlightened by all- atom molecular dynamics simulations AI翻译
  作者：Rizo, Josep; Sari, Levent; Jaczynska, Klaudia; Rosenmund, Christian; Lin, Milo M.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：The SNAP receptor (SNARE) proteins syntaxin-1, SNAP - 25, and synaptobrevin mediate neurotransmitter release by forming tight SNARE complexes that fuse synaptic vesicles with the plasma membranes in microseconds. Membrane fusion is generally explained by the action of proteins on macroscopic membrane properties such as curvature, elastic modulus, and tension, and a widespread model envisions that the SNARE motifs, juxtamembrane linkers, and C- terminal transmembrane regions of synaptobrevin an...
• Carbon starvation raises capacities in bacterial antibiotic resistance and viral auxiliary carbon metabolism in soils AI翻译
  作者：Xu, Qicheng; Zhang, He; Vandenkoornhuyse, Philippe; Guo, Shiwei; Kuzyakov, Yakov; Shen, Qirong; Ling, Ning
  作者单位：Nanjing Agricultural University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Rennes; Lanzhou University; University of Gottingen; University of Gottingen
  摘要：Organic carbon availability in soil is crucial for shaping microbial communities, yet, uncertainties persist concerning microbial adaptations to carbon levels and the ensuing ecological and evolutionary consequences. We investigated organic carbon metabolism, antibiotic resistance, and virus-host interactions in soils subjected to 40 y of chemical and organic fertilization that led to contrasting carbon availability: carbonpoor and carbonrich soils, respectively. Carbon - poor soils drove the ...
• Linear resistivity at van Hove singularities in twisted bilayer WSe2 AI翻译
  作者：Wei, Lingnan; Xu, Qiaoling; He, Yangchen; Li, Qingxin; Huang, Yan; Zhu, Wang; Watanabe, Kenji; Taniguchi, Takashi; Claassen, Martin; Rhodes, Daniel A.; Kennesh, Dante M.; Xian, Lede; Rubio, Angel; Wang, Lei
  作者单位：Nanjing University; Songshan Lake Materials Laboratory; Sichuan Normal University; University of Wisconsin System; University of Wisconsin Madison; National Institute for Materials Science; National Institute for Materials Science; University of Pennsylvania; RWTH Aachen University; Max Planck Society; Simons Foundation; Flatiron Institute; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University
  摘要：Different mechanisms driving a linear temperature dependence of the resistivity rho - T at van Hove singularities (VHSs) or metal- insulator transitions when doping a Mott insulator are being debated intensively with competing theoretical proposals. We experimentally investigate this using the exceptional tunability of twisted bilayer (TB) WSe2 by tracking the parameter regions where linear-in- Tresistivity is found in dependency of displacement fields, filling, and magnetic fields. We find th...
• Childhood maltreatment influences adult brain structurethrough its effects on immune, metabolic, and psychosocialfactors AI翻译
  作者：Orellana, Sofia C.; Bethlehem, Richard A. I.; Simpson-Kent, Ivan L.; van Harmele, Anne-Laura; Vertes, Petra E.; Bullmore, Edward T.
  作者单位：University of Cambridge; University of Cambridge; Leiden University; Leiden University - Excl LUMC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Pennsylvania; Leiden University - Excl LUMC; Leiden University
  摘要：Childhood maltreatment (CM) leads to a lifelong susceptibility to mental ill-healthwhich might be reflected by its effects on adult brain structure, perhaps indirectlymediated by its effects on adult metabolic, immune, and psychosocial systems. Indexingthese systemic factors via body mass index (BMI), C-reactive protein (CRP), and ratesof adult trauma (AT), respectively, we tested three hypotheses: (H1) CM has direct orindirect effects on adult trauma, BMI, and CRP; (H2) adult trauma, BMI, and...
• Formation of recurring transient Ca2+-based intercellular communities during Drosophila hematopoiesis AI翻译
  作者：Ben David, Saar; Ho, Kevin Y. L.; Tanentzapf, Guy; Zaritsky, Assaf
  作者单位：Ben-Gurion University of the Negev; University of British Columbia
  摘要：Tissue development occurs through a complex interplay between many individual cells. Yet, the fundamental question of how collective tissue behavior emerges from heterogeneous and noisy information processing and transfer at the single - cell level remains unknown. Here, we reveal that tissue scale signaling regulation can arise from local gap- junction mediated cell-cell signaling through the spatiotemporal establishment of an intermediate - scale of transient multicellular communication comm...
• Aflatoxin B1 and Epstein-Barr virus- induced CCL22 expression stimulates B cell infection AI翻译
  作者：Maroui, Mohamed Ali; Odongo, Grace Akinyi; Mundo, Lucia; Manara, Francesca; Mure, Fabrice; Fusil, Floriane; Jay, Antonin; Gheit, Tarik; Michailidis, Thanos M.; Ferrara, Domenico; Leoncini, Lorenzo; Murray, Paul; Manet, Evelyne; Ohlmann, Theophile; De Boevre, Marthe; De Saeger, Sarah; Cosset, Francois-Loic; Lazzi, Stefano; Accardi, Rosita; Herceg, Zdenko; Gruffat, Henri; Khoueiry, Rita
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; World Health Organization; International Agency for Research on Cancer (IARC); University of Limerick; University of Limerick; University of Siena; Ghent University; University of Johannesburg
  摘要：Epstein-Barr Virus (EBV) infects more than 90% of the adult population worldwide. EBV infection is associated with Burkitt lymphoma (BL) though alone is not sufficient to induce carcinogenesis implying the involvement of co- factors. BL is endemic in African regions faced with mycotoxins exposure. Exposure to mycotoxins and oncogenic viruses has been shown to increase cancer risks partly through the deregulation of the immune response. A recent transcriptome profiling of B cells exposed to afl...
• A conserved strategy to attack collagen: The activator domain in bacterial collagenases unwinds triple- helical collagen AI翻译
  作者：Serwanja, Jamil; Wieland, Alexander C.; Haubenhofer, Astrid; Brandstetter, Hans; Schoenauer, Esther
  作者单位：Salzburg University; Salzburg University
  摘要：Bacterial collagenases are important virulence factors, secreted by several pathogenic Clostridium, Bacillus, Spirochaetes, and Vibrio species. Yet, the mechanism by which these enzymes cleave collagen is not well understood. Based on biochemical and mutational studies we reveal that collagenase G (ColG) from Hathewaya histolytica recognizes and processes collagen substrates differently depending on their nature (fibrillar vs. soluble collagen); distinct dynamic interactions between the activa...
• Evolutionary and developmental specialization of foveal cell types in the marmoset AI翻译
  作者：Zhang, Lin; Cavallini, Martina; Wang, Junqiang; Xin, Ruiqi; Zhang, Qiangge; Feng, Guoping; Sanes, Joshua R.; Peng, Yi - Rong
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University
  摘要：In primates, high- acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal maturation. However, the extent of cellular similarity across anthropoid foveas and the molecular underpinnings of foveal maturation remain unclear. Here, we used high- throughput single-cell RNA sequencing to profile retinal cells of the common marmoset (Callithr...
• Dynamic brain communication underwriting face pareidolia AI翻译
  作者：Romagnano, Valentina; Kubon, Julian; Sokolov, Alexander N.; Fallgatter, Andreas J.; Braun, Christoph; Pavlova, Marina A.
  作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital
  摘要：Face pareidolia is a tendency to seeing faces in nonface images that reflects high tuning to a face scheme. Yet, studies of the brain networks underwriting face pareidolia are scarce. Here, we examined the time course and dynamic topography of gamma oscillatory neuromagnetic activity while administering a task with nonface images resembling a face. Images were presented either with canonical orientation or with display inversion that heavily impedes face pareidolia. At early processing stages,...
• Structure and design of Langya virus glycoprotein antigens AI翻译
  作者：Wang, Zhaoqian; Mccallum, Matthew; Yan, Lianying; Gibson, Cecily A.; Sharkey, William; Park, Young - Jun; V. Dang, Ha; Amaya, Moushimi; Person, Ashley; Broder, Christopher C.; Veeslera, David
  作者单位：University of Washington; University of Washington Seattle; Uniformed Services University of the Health Sciences - USA; Howard Hughes Medical Institute
  摘要：Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) glycoproteins which are the main targets of neutralizing antibodies. We show here that the LayV F and G glycoproteins promote membrane fusion with human, mouse, and hamster target cells using a different, yet unknown, receptor than Nipah virus (NiV) and Hendra virus (HeV) and that NiV- and HeV- elicited monoclonal an...