16期

最新文章

• Extracellular vesicles released by keratinocytes regulate melanosome maturation, melanocyte dendricity, and pigment transfer AI翻译
  作者：Prosperi, Marie- Therese; Giordano, Cecile; Gomez-Duro, Mireia; Hurbain, Ilse; Mace, Anne- Sophie; Raposo, Graca; D'Angelo, Gisela
  作者单位：Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS)
  摘要：Extracellular vesicles (EVs) facilitate the transfer of proteins, lipids, and genetic material between cells and are recognized as an additional mechanism for sustaining intercellular communication. In the epidermis, the communication between melanocytes and keratinocytes is tightly regulated to warrant skin pigmentation. Melanocytes synthesize the melanin pigment in melanosomes that are transported along the dendrites prior to the transfer of melanin pigment to keratinocytes. EVs secreted by ...
• The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom AI翻译
  作者：Hogan, Michael P.; Holding, Matthew L.; Nystrom, Gunnar S.; Colston, Timothy J.; Bartlett, Daniel A.; Mason, Andrew J.; Ellsworth, Schyler A.; Rautsaw, Rhett M.; Lawrence, Kylie C.; Strickland, Jason L.; He, Bing; Fraser, Peter; Margres, Mark J.; Gilberti, David M.; Gibbse, H. Lisle; Parkinson, Christopher L.; Rokyta, Darin R.
  作者单位：State University System of Florida; Florida State University; University of Michigan System; University of Michigan; University of Puerto Rico; University of Puerto Rico Mayaguez; Clemson University; University System of Ohio; Ohio State University; State University System of Florida; University of South Florida; Washington State University; University of South Alabama
  摘要：Developmental phenotypic changes can evolve under selection imposed by age- and size -related ecological differences. Many of these changes occur through programmed alterations to gene expression patterns, but the molecular mechanisms and generegulatory networks underlying these adaptive changes remain poorly understood. Many venomous snakes, including the eastern diamondback rattlesnake (Crotalus adamanteus), undergo correlated changes in diet and venom expression as snakes grow larger with a...
• The cAMP signaling module regulates sperm motility in the liverwort Marchantia polymorpha AI翻译
  作者：Yamamoto, Chiaki; Takahashi, Fumio; Suetsugu, Noriyuki; Yamada, Kazumasa; Yoshikawa, Shinya; Kohchi, Takayuki; Kasahara, Masahiro
  作者单位：Ritsumeikan University; University of Tokyo; Fukui Prefectural University; Kyoto University; University of Tsukuba; Toho University
  摘要：Adenosine 3 ',5 '-cyclic monophosphate (cAMP) is a universal signaling molecule that acts as a second messenger in various organisms. It is well established that cAMP plays essential roles across the tree of life, although the function of cAMP in land plants has long been debated. We previously identified the enzyme with both adenylyl cyclase (AC) and cAMP phosphodiesterase (PDE) activity as the cAMP-synthesis/hydrolysis enzyme COMBINED AC with PDE (CAPE) in the liverwort Marchantia polymorpha...
• Ion transport in muscle acetylcholine receptor maintained by conserved salt bridges between the pore and lipid membrane AI翻译
  作者：Alhalhooly, Lina; Sine, Steven M.
  作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic
  摘要：Pores through ion channels rapidly transport small inorganic ions along their electrochemical gradients. Here, applying single- channel electrophysiology and mutagenesis to the archetypal muscle nicotinic acetylcholine receptor (AChR) channel, we show that a conserved pore- peripheral salt bridge partners with those in the other subunits to regulate ion transport. Disrupting the salt bridges in all five receptor subunits greatly decreases the amplitude of the unitary current and increases its ...
• Harmonic resonance and entrainment of propagating chemical waves by external mechanical stimulation in BZ self-oscillating hydrogels AI翻译
  作者：Geher-Herczegh, Tunde; Wang, Zuowei; Masuda, Tsukuru; Vasudevan, Nandini; Yoshida, Ryo; Hayashi, Yoshikatsu
  作者单位：University of Reading; University of Reading; University of Tokyo; University of Tokyo
  摘要：Smart polymer materials that are nonliving yet exhibit complex life -like or biomimetic behaviors have been the focus of intensive research over the past decades, in the quest to broaden our understanding of how living systems function under nonequilibrium conditions. Identification of how chemical and mechanical coupling can generate resonance and entrainment with other cells or external environment is an important research question. We prepared Belousov-Zhabotinsky (BZ) selfoscillating hydro...
• Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair AI翻译
  作者：Shao, Sida; Zhang, Nan; Specht, Gregory P.; You, Shaochen; Song, Lirui; Fu, Qiangwei; Huang, David; You, Hengyao; Shu, Jian; Domissy, Alain; Li, Shuangwei; Nguyen-Tran, Van; Joseph, Sean B.; Chatterjee, Arnab K.; Chen, Jeffrey Jian; Schultz, Peter G.; Bollong, Michael J.
  作者单位：Westlake University; Scripps Research Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Scripps Research Institute
  摘要：Type 2 alveolar epithelial cells (AEC2s) are stem cells in the adult lung that contribute to lower airway repair. Agents that promote the selective expansion of these cells might stimulate regeneration of the compromised alveolar epithelium, an etiology- defining event in several pulmonary diseases. From a high- content imaging screen of the drug repurposing library ReFRAME, we identified that dipeptidyl peptidase 4 (DPP4) inhibitors, widely used type 2 diabetes medications, selectively expand...
• Emerging roles for ABC transporters as virulence factors in uropathogenic Escherichia coli AI翻译
  作者：Shea, Allyson E.; Forsyth, Valerie S.; Stocki, Jolie A.; Mitchell, Taylor J.; Frick-Cheng, Arwen E.; Smith, Sara N.; Hardy, Sicily L.; Mobley, Harry L. T.
  作者单位：University of Michigan System; University of Michigan; University of South Alabama; Tufts University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Urinary tract infections (UTI) account for a substantial financial burden globally. Over 75% of UTIs are caused by uropathogenic Escherichia coli (UPEC), which have demonstrated an extraordinarily rapid growth rate in vivo. This rapid growth rate appears paradoxical given that urine and the human urinary tract are relatively nutrient- restricted. Thus, we lack a fundamental understanding of how uropathogens propel growth in the host to fuel pathogenesis. Here, we used large in silico, in vivo,...
• Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence AI翻译
  作者：Zhong, Qiu; Liao, Binyou; Liu, Jiazhen; Shen, Wei; Wang, Jing; Wei, Leilei; Ma, Yansong; Dong, Pu-Ting; Bor, Batbileg; McLean, Jeffrey S.; Chang, Yunjie; Shi, Wenyuan; Cen, Lujia; Wu, Miaomiao; Liul, Jun; Li, Yan; He, Xuesong; Le, Shuai
  作者单位：Sichuan University; Chongqing Medical University; Army Medical University; Capital Medical University; Harvard University; Harvard School of Dental Medicine; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Zhejiang University; Zhejiang University; Yale University
  摘要：Bacteriophages (phages) play critical roles in modulating microbial ecology. Within the human microbiome, the factors influencing the long - term coexistence of phages and bacteria remain poorly investigated. Saccharibacteria (formerly TM7) are ubiquitous members of the human oral microbiome. These ultrasmall bacteria form episymbiotic relationships with their host bacteria and impact their physiology. Here, we showed that during surface- associated growth, a human oral Saccharibacteria isolat...
• A survey of chromosomal instability measures across mechanistic models AI翻译
  作者：Lynch, Andrew R.; Bradford, Shermineh; Zhou, Amber S.; Oxendine, Kim; Henderson, Les; Horner, Vanessa L.; Weaver, Beth A.; Burkard, Mark E.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：Chromosomal instability (CIN) is the persistent reshuffling of cancer karyotypes via chromosome mis- segregation during cell division. In cancer, CIN exists at varying levels that have differential effects on tumor progression. However, mis- segregation rates remain challenging to assess in human cancer despite an array of available measures. We evaluated measures of CIN by comparing quantitative methods using specific, inducible phenotypic CIN models of chromosome bridges, pseudobipolar spind...
• Climate change impacts on mesophotic regions of the Great Barrier Reef AI翻译
  作者：McWhorter, Jennifer K.; Halloran, Paul R.; Roff, George; Mumby, Peter J.
  作者单位：University of Exeter; University of Queensland; National Oceanic Atmospheric Admin (NOAA) - USA; Atlantic Oceanographic & Meteorological Laboratory (AOML); Commonwealth Scientific & Industrial Research Organisation (CSIRO)
  摘要：Climate change projections for coral reefs are founded exclusively on sea surface temperatures (SST). While SST projections are relevant for the shallowest reefs, neglecting ocean stratification overlooks the striking differences in temperature experienced by deeper reefs for all or part of the year. Density stratification creates a buoyancy barrier partitioning the upper and lower parts of the water column. Here, we mechanistically downscale climate models and quantify patterns of thermal str...