16期

最新文章

• Genetic mechanism regulating diversity in the placement of eyes on the head of animals AI翻译
  作者：Puli, Oorvashi Roy; Gogia, Neha; Chimata, Anuradha Venkatakrishnan; Yorimitsu, Takeshi; Nakagoshi, Hideki; Kango-Singh, Madhuri; Singh, Amit
  作者单位：University System of Ohio; University of Dayton; Okayama University; University System of Ohio; University of Dayton; University System of Ohio; University of Dayton; Indiana State University; International Genomics Consortium
  摘要：Despite the conservation of genetic machinery involved in eye development, there is a strong diversity in the placement of eyes on the head of animals. Morphogen gradients of signaling molecules are vital to patterning cues. During Drosophila eye development, Wingless (Wg), a ligand of Wnt/Wg signaling, is expressed anterolaterally to form a morphogen gradient to determine the eye- versus head- specific cell fate. The underlying mechanisms that regulate this process are yet to be fully underst...
• Identification and removal of unexpected proliferative off- target cells emerging after iPSC- derived pancreatic islet cell implantation AI翻译
  作者：Hiyoshi, Hideyuki; Sakuma, Kensuke; Asano, Shinya; Napier, Stephanie C.; Konagaya, Shuhei; Mochida, Taisuke; Ueno, Hikaru; Watanabe, Takeshi; Kassai, Yoshiaki; Matsumoto, Hirokazu; Ito, Ryo; Toyoda, Taro
  作者单位：Takeda Pharmaceutical Company Ltd; Kyoto University; Takeda Pharmaceutical Company Ltd; Kyoto University
  摘要：Differentiation of pancreatic endocrine cells from human pluripotent stem cells (PSCs) has been thoroughly investigated for application in cell therapy against diabetes. In the context of induced pancreatic endocrine cell implantation, previous studies have reported graft enlargement resulting from off - target pancreatic lineage cells. However, there is currently no documented evidence of proliferative off- target cells beyond the pancreatic lineage in existing studies. Here, we show that the...
• Two- way feedback between chromatin compaction and histone modification state explains Saccharomyces cerevisiae heterochromatin bistability AI翻译
  作者：Miangolarra, Ander Movilla; Saxton, Daniel S.; Yan, Zhi; Rine, Jasper; Howard, Martin
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of California System; University of California Berkeley
  摘要：Compact chromatin is closely linked with gene silencing in part by sterically masking access to promoters, inhibiting transcription factor binding and preventing polymerase from efficiently transcribing a gene. However, a broader hypothesis suggests that chromatin compaction can be both a cause and a consequence of the locus histone modification state, with a tight bidirectional interaction underpinning bistable transcriptional states. To rigorously test this hypothesis, we developed a mathema...
• USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy AI翻译
  作者：Li, Haiou; Sun, Yishuang; Yao, Yingmeng; Ke, Shanwen; Zhang, Nannan; Xiong, Wenjun; Shi, Jie; He, Chuan; Xiao, Xiangling; Yu, Haisheng; Dai, Panpan; Xiang, Bolin; Xing, Xixin; Xu, Gaoshan; Song, Wenjing; Song, Jiquan; Zhang, Jinfang
  作者单位：Wuhan University; Wuhan University; Zhengzhou University; Zhengzhou University; Wuhan University; Wuhan University
  摘要：Ferroptosis is an iron- dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological and pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion of Usp8 (ubiquitin- specific protease 8) in intestinal epithelial cells (IECs) leads to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied ...
• Widespread, bipartisan aversion exists to neighbors owning AR-15s or storing guns insecurely AI翻译
  作者：Sola, Justin L.; Pickett, Justin T.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; State University of New York (SUNY) System; University at Albany, SUNY
  摘要：Over 45,000 gun deaths occur annually in the United States, a country with more than 100 million gun owners and more than 350 million guns. Nevertheless, passing legislation to reduce gun violence is difficult because the issue is intensely polarized. Polls asking about general gun policies (e.g., AR - 15 restrictions) demonstrate that, at least in the abstract, Americans disagree vehemently about whether civilians should be able to keep and bear arms. It is possible, however, that a hidden co...
• A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues AI翻译
  作者：Szodorai, Edit; Hevesi, Zsofia; Wagner, Ludwig; Hoekfelt, Tomas G. M.; Harkany, Tibor; Schnell, Robert
  作者单位：Karolinska Institutet; Medical University of Vienna; Medical University of Vienna
  摘要：Vesicular release of neurotransmitters and hormones relies on the dynamic assembly of the exocytosis/trans-SNARE complex through sequential interactions of synaptobrevins, syntaxins, and SNAP-25. Despite SNARE- mediated release being fundamental for intercellular communication in all excitable tissues, the role of auxiliary proteins modulating the import of reserve vesicles to the active zone, and thus, scaling repetitive exocytosis remains less explored. Secretagogin is a Ca2+- sensor protein...
• Species- level, digitized wildlife trade data are essential for achieving biodiversity targets AI翻译
  作者：Tlusty, Michael F.; Cassey, Phillip; Rhyne, Andrew L.; Omrow, Delon A.; Stoett, Peter
  作者单位：University of Massachusetts System; University of Massachusetts Boston; University of Adelaide; Roger Williams University; Ontario Tech University
• Top-down modulation in canonical cortical circuits with short-term plasticity AI翻译
  作者：Waitzmann, Felix; Wu, Yue Kris; Gjorgjieva, Julijana
  作者单位：Technical University of Munich; Max Planck Society
  摘要：Cortical dynamics and computations are strongly influenced by diverse GABAergic interneurons, including those expressing parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP). Together with excitatory (E) neurons, they form a canonical microcircuit and exhibit counterintuitive nonlinear phenomena. One instance of such phenomena is response reversal, whereby SST neurons show opposite responses to top-down modulation via VIP depending on the presence of bottom-up sensory ...
• Grow now, pay later: When should a bacterium go into debt? AI翻译
  作者：Lopez, Jaime G.; Hein, Yair; Erez, Amir
  作者单位：Stanford University; Hebrew University of Jerusalem; Stanford University; Utrecht University
  摘要：Microbes grow in a wide variety of environments and must balance growth and stress resistance. Despite the prevalence of such trade-offs, understanding of their role in nonsteady environments is limited. In this study, we introduce a mathematical model of growth debt, where microbes grow rapidly initially, paying later with slower growth or heightened mortality. We first compare our model to a classical chemostat experiment, validating our proposed dynamics and quantifying Escherichia coli's s...
• Blink and you see it AI翻译
  作者：Rolfs, Martin; Huebner, Carolin
  作者单位：Humboldt University of Berlin; Humboldt University of Berlin; Technical University of Berlin; Technische Universitat Chemnitz