16期

最新文章

• Missing validation of key features in HCN single- channel recordings AI翻译
  作者：Benndorf, Klaus; Difrancesco, Dario
  作者单位：Friedrich Schiller University of Jena; University of Milan
• People see more of their biases in algorithms AI翻译
  作者：Celiktutan, Begum; Cadario, Romain; Morewedge, Carey K.
  作者单位：Erasmus University Rotterdam; Erasmus University Rotterdam - Excl Erasmus MC; Boston University
  摘要：Algorithmic bias occurs when algorithms incorporate biases in the human decisions on which they are trained. We find that people see more of their biases (e.g., age, gender, race) in the decisions of algorithms than in their own decisions. Research participants saw more bias in the decisions of algorithms trained on their decisions than in their own decisions, even when those decisions were the same and participants were incentivized to reveal their true beliefs. By contrast, participants saw ...
• Identification of secretory autophagy as a mechanism modulating activity- induced synaptic remodeling AI翻译
  作者：Chang, Yen-Ching; Gao, Yuan; Lee, Joo Yeun; Langen, Jennifer; Chang, Karen T.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Southern California; University of Southern California
  摘要：The ability of neurons to rapidly remodel their synaptic structure and strength in response to neuronal activity is highly conserved across species and crucial for complex brain functions. However, mechanisms required to elicit and coordinate the acute, activity- dependent structural changes across synapses are not well understood, as neurodevelopment and structural plasticity are tightly linked. Here, using an RNAi screen in Drosophila against genes affecting nervous system functions in human...
• Needs for a conceptual bridge between biological domestication and early food globalization AI翻译
  作者：Liu, Xinyi; Jones, Martin
  作者单位：Washington University (WUSTL); University of Cambridge
  摘要：The past 15 y has seen much development in documentation of domestication of plants and animals as gradual traditions spanning millennia. There has also been considerable momentum in understanding the dispersals of major domes ticated taxa across continents spanning thousands of miles. The two processes are often considered within different theoretical strains. What is missing from our repertoire of explanations is a conceptual bridge between the protracted process over millennia and the multi...
• Isomer- resolved unimolecular dynamics of the hydroperoxyalkyl intermediate (•QOOH) in cyclohexane oxidation AI翻译
  作者：Qian, Yujie; Roy, Tarun Kumar; Jasper, Ahren W.; Sojdak, Christopher A.; Kozlowski, Marisa C.; Klippenstein, Stephen J.; Lester, Marsha I.
  作者单位：University of Pennsylvania; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：The oxidation of cycloalkanes is important in the combustion of transportation fuels and in atmospheric secondary organic aerosol formation. A transient carbon- centered radical intermediate (center dot QOOH) in the oxidation of cyclohexane is identified through its infrared fingerprint and time- and energy- resolved unimolecular dissociation dynamics to hydroxyl (OH) radical and bicyclic ether products. Although the cyclohexyl ring structure leads to three nearly degenerate center dot QOOH is...
• Label- free and amplification- free viral RNA quantification from primate biofluids using a trapping- assisted optofluidic nanopore platform AI翻译
  作者：Sampad, Mohammad Julker Neyen; Saiduzzaman, S. M.; Walker, Zach J.; Wells, Tanner N.; Wayment, Jesse X.; Ong, Ephraim M.; Mdaki, Stephanie D.; Tamhankar, Manasi A.; Yuzvinsky, Thomas D.; Patterson, Jean L.; Hawkins, Aaron R.; Schmidt, Holger
  作者单位：University of California System; University of California Santa Cruz; Brigham Young University; Texas Biomedical Research Institute
  摘要：Viral outbreaks can cause widespread disruption, creating the need for diagnostic tools that provide high performance and sample versatility at the point of use with moderate complexity. Current gold standards such as PCR and rapid antigen tests fall short in one or more of these aspects. Here, we report a label - free and amplification - free nanopore sensor platform that overcomes these challenges via direct detection and quantification of viral RNA in clinical samples from a variety of biol...
• Bioinspired multiscale adaptive suction on complex dry surfaces enhanced by regulated water secretion AI翻译
  作者：Yue, Tianqi; Si, Weiyong; Keller, Alex; Yang, Chenguang; Bloomfield-Gadelha, Hermes; Rossiter, Jonathan
  作者单位：University of Bristol; University of Bristol; University of West England; University of West England; University of West England; University of Bristol; University of Essex
  摘要：Suction is a highly evolved biological adhesion strategy for soft - body organisms to achieve strong grasping on various objects. Biological suckers can adaptively attach to dry complex surfaces such as rocks and shells, which are extremely challenging for current artificial suction cups. Although the adaptive suction of biological suckers is believed to be the result of their soft body's mechanical deformation, some studies imply that in- sucker mucus secretion may be another critical factor ...
• Uncovering the dual role of dimensionless radius in buckling of spherical shells with random geometric imperfections AI翻译
  作者：Baizhikova, Zheren; Ballarini, Roberto; Le, Jia-Liang
  作者单位：University of Houston System; University of Houston; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Localized deformation and randomly shaped imperfections are salient features of buckling -type instabilities in thin -walled load -bearing structures. However, it is generally agreed that their complex interactions in response to mechanical loading are not yet sufficiently understood, as evidenced by buckling -induced catastrophic failures which continue to today. This study investigates how the intimate coupling between localization mechanisms and geometric imperfections combine to determine ...
• The time course of feature- selective attention inside and outside the focus of spatial attention AI翻译
  作者：Hillyard, Steven A.; Andersen, Soren K.
  作者单位：University of Southern Denmark; University of Aberdeen; University of California System; University of California San Diego; Leibniz Association; Leibniz Institut fur Neurobiologie (LIN)
  摘要：Research on attentional selection of stimulus features has yielded seemingly contradictory results. On the one hand, many experiments in humans and animals have observed a global facilitation of attended features across the entire visual field, even when spatial attention is focused on a single location. On the other hand, several event- related potential studies in humans reported that attended features are enhanced at the attended location only. The present experiment demonstrates that these...
• Caenorhabditis elegans telomere- binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA AI翻译
  作者：Padmanaban, Shilpa; Lambacher, Nils J.; Tesmer, Valerie M.; Zhang, Jingjing; Shibuya, Hiroki; Nandakumar, Jayakrishnan
  作者单位：University of Michigan System; University of Michigan; Washington University (WUSTL); University of Gothenburg; RIKEN
  摘要：Protecting chromosome ends from misrecognition as double- stranded (ds) DNA breaks is fundamental to eukaryotic viability. The protein complex shelterin prevents a DNA damage response at mammalian telomeres. Mammalian shelterin proteins TRF1 and TRF2 and their homologs in yeast and protozoa protect telomeric dsDNA. N- terminal homodimerization and C- terminal Myb- domain- mediated dsDNA binding are two structural hallmarks of end protection by TRF homologs. Yet our understanding of how Caenorh...