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作者：Marinelli, Fabrizio; Faraldo- Gomez, Jose D.
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
摘要：Secondary-active transporters catalyze the movement of myriad substances across all cellular membranes, typically against opposing concentration gradients, and without consuming any ATP. To do so, these proteins employ an intriguing structural mechanism evolved to be activated only upon recognition or release of the transported species. We examine this self-regulated mechanism using a homolog of the cardiac Na+/Ca2+ exchanger as a model system. Using advanced computer simulations, we map out t...
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作者：Wallace, Laura E.; Reeves, Stephanie L.; Spencer, Steven J.; Wilson, Timothy
作者单位：University of Chicago; University System of Ohio; Ohio State University; University System of Ohio; Ohio University
摘要：Many mainstream organizations celebrate their historical successes. In their history, however, they often marginalized racial minorities, women, and other underrepresented groups. We suggest that when organizations celebrate their histories, even without mentioning historical marginalization, they can undermine belonging and intentions to join the organization among historically marginalized groups. Four experiments demonstrate that Black participants who were exposed to an organization that c...
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作者：Ichimura, Yuki; Konishi, Risa; Shobo, Miwako; Tanaka, Ryota; Kubota, Noriko; Kayama, Hisako; Takeda, Kiyoshi; Nomura, Toshifumi; Fujimoto, Manabu; Okiyama, Naoko
作者单位：Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Tokyo Women's Medical University; University of Tsukuba; University of Osaka; University of Osaka; University of Osaka
摘要：Anti- melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is characterized by amyopathic DM with interstitial lung disease (ILD). Patients with anti-MDA5 antibody-associated ILD frequently develop rapidly progression and present high mortality rate in the acute phase. Here, we established a murine model of ILD mediated by autoimmunity against MDA5. Mice immunized with recombinant murine MDA5 whole protein, accompanied with complete Freund's adjuvant once a ...
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作者：Miyoshi, Goichi; Ueta, Yoshifumi; Yagasaki, Yuki; Kishi, Yusuke; Fishell, Gord; Machold, Robert P.; Miyata, Mariko
作者单位：Gunma University; Tokyo Women's Medical University; New York University; University of Tokyo; University of Tokyo; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain territories, traverse a convoluted migratory path to reach the neocortex. These interneuron precursors undergo sequential phases of tangential and radial migration before settling into specific laminae during differentiation. Here, we show that the developmental trajectory of FoxG1 expression is dynamically controlled in these interneuron precursors at critical junctures of migration. By utilizing mouse genetic...
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作者：Ryan, Calen P.; Lee, Nanette R.; Carba, Delia B.; Macisaac, Julie L.; Lin, David T. S.; Atashzay, Parmida; Belsky, Daniel W.; Kobor, Michael S.; Kuzawa, Christopher W.
作者单位：Columbia University; University of San Carlos; BC Children's Hospital; BC Children's Hospital Research Institute; University of British Columbia; Columbia University; Canadian Institute for Advanced Research (CIFAR); University of British Columbia; Northwestern University
摘要：A central prediction of evolutionary theory is that energy invested into reproduction comes at the expense of somatic maintenance and repair, accelerating biological aging. Supporting this prediction are findings that high fertility among women predicts shorter lifespan and poorer health later in life. However, biological aging is thought to begin before age- related health declines, limiting the applicability of morbidity and mortality for studying the aging process earlier in life. Here, we ...
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作者：Wu, Linjuan; Zhang, Liming; Feng, Shengyong; Chen, Lu; Lin, Cai; Wang, Gang; Zhu, Yibin; Wang, Penghua; Cheng, Gong
作者单位：Tsinghua University; Peking University; Shenzhen Bay Laboratory; Shenzhen Center for Disease Control & Prevention (SZCDC); University of Connecticut
摘要：Mosquito - borne flaviviruses such as dengue (DENV) and Zika (ZIKV) cause hundreds of millions of infections annually. The single- stranded RNA genome of flaviviruses is translated into a polyprotein, which is cleaved equally into individual functional proteins. While structural proteins are packaged into progeny virions and released, most of the nonstructural proteins remain intracellular and could become cytotoxic if accumulated over time. However, the mechanism by which nonstructural protei...
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作者：Cui, Aoyuan; Xue, Yaqian; Su, Weitong; Lin, Jing; Liu, Yuxiao; Cai, Genxiang; Wan, Qin; Jiang, Yang; Ding, Dong; Zheng, Zengpeng; Wei, Shuang; Li, Wenjing; Shen, Jiaxin; Wen, Jian; Huang, Mengyao; Zhao, Jiuxiang; Zhang, Xiaojie; Zhao, Yuwu; Li, Hong; Ying, Hao; Zhang, Haibing; Bi, Yan; Chen, Yan; Xu, Aimin; Xu, Yong; Li, Yu
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Nutrition & Health, CAS; Southwest Medical University; Tianjin University of Science & Technology; Southwest Medical University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; Nanjing University; University of Hong Kong; University of Hong Kong; University of Hong Kong
摘要：Glucose is required for generating heat during cold- induced nonshivering thermogenesis in adipose tissue, but the regulatory mechanism is largely unknown. CREBZF has emerged as a critical mechanism for metabolic dysfunction- associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). We investigated the roles of CREBZF in the control of thermogenesis and energy metabolism. Glucose induces CREBZF in human white adipose tissue (WAT) and inguinal WAT (...
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作者：Levin, Bruce R.; Berryhill, Brandon A.; Gil-Gil, Teresa; Manuel, Joshua A.; Smith, Andrew P.; Choby, Jacob E.; Andersson, Dan I.; Weiss, David S.; Baquero, Fernando
作者单位：Emory University; Emory University; Emory University; Uppsala University; Emory University; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; Hospital Universitario Ramon y Cajal; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP
摘要：Antibiotics are considered one of the most important contributions to clinical medicine in the last century. Due to the use and overuse of these drugs, there have been increasing frequencies of infections with resistant pathogens. One form of resistance, heteroresistance, is particularly problematic; pathogens appear sensitive to a drug by common susceptibility tests. However, upon exposure to the antibiotic, resistance rapidly ascends, and treatment fails. To quantitatively explore the proces...
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作者：Siedel, Samuel; Gu, Tianle
作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National Polytechnique de Grenoble; Centre National de la Recherche Scientifique (CNRS)
摘要：The distortion by gravity of a quasi -static bubble attached on an upward -facing surface in a quiescent liquid is investigated. The contact angle evolution during the growth of such a bubble is studied, and the consequences on the motion of the contact line between the solid and the interface are discussed. From the initial case of a bubble attached to the rim of a nucleation site, the contact line can move inside the cavity for a highly wetting fluid, causing premature departure. For a highe...
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作者：Hou, Jiawen; McCormack, M. Luke; Reich, Peter B.; Sun, Tao; Phillips, Richard P.; Lambers, Hans; Chen, Han Y. H.; Ding, Yiyang; Comas, Louise H.; Valverde-Barrantes, Oscar J.; Solly, Emily F.; Freschet, Gregoire T.
作者单位：Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Western Sydney University; Indiana University System; Indiana University Bloomington; University of Western Australia; Lakehead University; University of Helsinki; University of Helsinki; Colorado State University System; Colorado State University Fort Collins; United States Department of Agriculture (USDA); State University System of Florida; Florida International University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS)
摘要：Fine root lifespan is a critical trait associated with contrasting root strategies of resource acquisition and protection. Yet, its position within the multidimensional root economics space synthesizing global root economics strategies is largely uncertain, and it is rarely represented in frameworks integrating plant trait variations. Here, we compiled the most comprehensive dataset of absorptive median root lifespan (MRL) data including 98 observations from 79 woody species using (mini- )rhiz...
