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作者：Smith, Madeleine R.; Naeli, Parisa; Jafarnejad, Seyed M.; Costa, Guilherme
作者单位：Queens University Belfast; Queens University Belfast
摘要：Regulation of subcellular messenger (m)RNA localization is a fundamental biological mechanism, which adds a spatial dimension to the diverse layers of post - transcriptional control of gene expression. The cellular compartment in which mRNAs are located may define distinct aspects of the encoded proteins, ranging from production rate and complex formation to localized activity. Despite the detailed roles of localized mRNAs that have emerged over the past decades, the identity of factors anchor...
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作者：Mondal, Dipon K.; Xie, Christopher; Pascal, Gabriel J.; Buraschi, Simone; Iozzo, Renato V.
作者单位：Thomas Jefferson University; Thomas Jefferson University
摘要：The complex interplay between malignant cells and the cellular and molecular components of the tumor stroma is a key aspect of cancer growth and development. These tumor- host interactions are often affected by soluble bioactive molecules such as proteoglycans. Decorin, an archetypical small leucine - rich proteoglycan primarily expressed by stromal cells, affects cancer growth in its soluble form by interacting with several receptor tyrosine kinases (RTK). Overall, decorin leads to a context ...
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作者：Nong, Daguan; Haviland, Zachary K.; Zexer, Nerya; Pfaff, Sarah A.; Cosgrove, Daniel J.; Tien, Ming; Anderson, Charles T.; Hancock, William O.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Degrading cellulose is a key step in the processing of lignocellulosic biomass into bioethanol. Cellobiose, the disaccharide product of cellulose degradation, has been shown to inhibit cellulase activity, but the mechanisms underlying product inhibition are not clear. We combined single- molecule imaging and biochemical investigations with the goal of revealing the mechanism by which cellobiose inhibits the activity of Trichoderma reesei Cel7A, a well- characterized exo- cellulase. We find tha...
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作者：Howard, Jeremy; Huang, Austin; Li, Zhiyuan; Tufekci, Zeynep; Zdimal, Vladimir; van der Westhuizen, Helene-Mari; von Delft, Arne; Price, Amy; Fridman, Lex; Tang, Lei-Han; Tang, Viola; Watson, Gregory L.; Bax, Christina E.; Shaikh, Reshama; Questier, Frederik; Hernandez, Danny; Chu, Larry F.; Ramirez, Christina M.; Rimoin, Anne W.
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作者：Janet, Remi; Smallwood, Jonathan; Hutcherson, Cendri A.; Plassmann, Hilke; McKeown, Bronte; Tusche, Anita
作者单位：Queens University - Canada; University of Toronto; University of Toronto; INSEAD Business School; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; California Institute of Technology
摘要：Making healthy dietary choices is essential for keeping weight within a normal range. Yet many people struggle with dietary self - control despite good intentions. What distinguishes neural processing in those who succeed or fail to implement healthy eating goals? Does this vary by weight status? To examine these questions, we utilized an analytical framework of gradients that characterize systematic spatial patterns of large - scale neural activity, which have the advantage of considering the...
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作者：Jo, Kyoung-nam
作者单位：Kangwon National University
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作者：Duque, Carlos M.; Hall, Douglas M.; Tyukodi, Botond; Hagan, Michael F.; Santangelo, Christian D.; Grason, Gregory M.
作者单位：Max Planck Society; University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst; Babes Bolyai University from Cluj; Brandeis University; Syracuse University
摘要：We propose and investigate an extension of the Caspar-Klug symmetry principles for viral capsid assembly to the programmable assembly of size -controlled triply periodic polyhedra, discrete variants of the Primitive, Diamond, and Gyroid cubic minimal surfaces. Inspired by a recent class of programmable DNA origami colloids, we demonstrate that the economy of design in these crystalline assemblies-in terms of the growth of the number of distinct particle species required with the increased size...
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作者：Gong, Yamin; Wang, Zhifeng; Zong, Wen; Shi, Ruifeng; Sun, Wenli; Wang, Sijia; Peng, Bin; Takeda, Shunichi; Wang, Zhao-Qi; Xu, Xingzhi
作者单位：Shenzhen University; Leibniz Association; Leibniz Institut fur Alternsforschung - Fritz-Lipmann-Institut (FLI); Shandong University; Friedrich Schiller University of Jena
摘要：The S - phase checkpoint involving CHK1 is essential for fork stability in response to fork stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation. However, it is unclear how the activity of PARP1 is regulated. Here, we found that UFMylation is required for the efficient activation of CHK1 by UFMylating PARP1 at K548 during replication stress. Inactivation of UFL1, the E3 enzyme essential for UFMylation, delayed CHK1 activation and inhibits nascent DNA degra...
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作者：Koehler, Robin; Murray, Sean M.
摘要：The ParABS system is crucial for the faithful segregation and inheritance of many bacterial chromosomes and low - copy - number plasmids. However, despite extensive research, the spatiotemporal dynamics of the ATPase ParA and its connection to the dynamics and positioning of the ParB - coated cargo have remained unclear. In this study, we utilize high - throughput imaging, quantitative data analysis, and computational modeling to explore the in vivo dynamics of ParA and its interaction with Pa...
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作者：Stringer, Emily J.; Gruber, Bernd; Sarre, Stephen D.; Wardle, Glenda M.; Edwards, Scott V.; Dickman, Christopher R.; Greenville, Aaron C.; Duncan, Richard P.
作者单位：University of Canberra; University of Sydney; Harvard University
摘要：Increasing environmental threats and more extreme environmental perturbations place species at risk of population declines, with associated loss of genetic diversity and evolutionary potential. While theory shows that rapid population declines can cause loss of genetic diversity, populations in some environments, like Australia's arid zone, are repeatedly subject to major population fluctuations yet persist and appear able to maintain genetic diversity. Here, we use repeated population samplin...
