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作者：Katerndahl, Casey D. S.; Rogers, Olivia R. S.; Day, Ryan B.; Xu, Ziheng; Helton, Nichole M.; Ramakrishnan, Sai Mukund; Miller, Christopher A.; Ley, Timothy J.
作者单位：Washington University (WUSTL)
摘要：The underlying mechanism(s) by which the PML::RARA fusion protein initiates acute promyelocytic leukemia is not yet clear. We defined the genomic binding sites of PML::RARA in primary mouse and human hematopoietic progenitor cells with V5-tagged PML::RARA, using anti-V5-PML::RARA chromatin immunoprecipitation sequencing and CUT&RUN approaches. Most genomic PML::RARA binding sites were found in regions that were already chromatin-accessible (defined by ATAC-seq) in unmanipulated, wild-type prom...
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作者：Senyuk, Bohdan; Wu, Jin-Sheng; Smalyukh, Ivan I.
作者单位：University of Colorado System; University of Colorado Boulder; Hiroshima University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
摘要：Many living and artificial systems show similar emergent behavior and collective motions on different scales, starting from swarms of bacteria to synthetic active particles, herds of mammals, and crowds of people. What all these systems often have in common is that new collective properties like flocking emerge from interactions between individual self-propelled or driven units. Such systems are naturally out-of-equilibrium and propel at the expense of consumed energy. Mimicking nature by maki...
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作者：Hellsberg, Eva; Boytsov, Danila; Chen, Qingyang; Niello, Marco; Freissmuth, Michael; Rudnick, Gary; Zhang, Yuan-Wei; Sandtner, Walter; Forrest, Lucy R.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Medical University of Vienna; Guangzhou University; Yale University
摘要：Clearance of serotonin (5 - hydroxytryptamine, 5 - HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (SERT), which couples this process to the movement of a Na + ion down its chemical gradient. After release of 5 - HT and Na + into the cytoplasm, the transporter faces a rate - limiting challenge of resetting its conformation to be primed again for 5 - HT and Na + binding. Early studies of vesicles containing native SERT revealed that K + gradients can pr...
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作者：Song, David Y.; Stubbe, Joanne; Nocera, Daniel G.
作者单位：Harvard University
摘要：Ribonucleotide reductases (RNRs) are essential enzymes that catalyze the de novo transformation of nucleoside 5 '- di(tri)phosphates [ND(T)Ps, where N is A, U, C, or G] to their corresponding deoxynucleotides. Despite the diversity of factors required for function and the low sequence conservation across RNRs, a unifying apparatus consolidating RNR activity is explored. We combine aspects of the protein subunit simplicity of class II RNR with a modified version of Escherichia coli class la pho...
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作者：Cheung, Ka Lung; Zhao, Li; Sharma, Rajal; Ghosh, Anurupa Abhijit; Appiah, Michael; Sun, Yifei; Jaganathan, Anbalagan; Hu, Yuan; Lejeune, Alannah; Xu, Feihong; Han, Xinye; Wang, Xueting; Zhang, Fan; Ren, Chunyan; Walsh, Martin J.; Xiong, Huabao; Tsankov, Alexander; Zhou, Ming-Ming
作者单位：Icahn School of Medicine at Mount Sinai; Jilin University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Class II histone deacetylases (HDACs) are important in regulation of gene transcription during T cell development. However, our understanding of their cell - specific functions is limited. In this study, we reveal that class IIa Hdac4 and Hdac7 (Hdac4/7) are selectively induced in transcription, guiding the lineage - specific differentiation of mouse T - helper 17 (Th17) cells from naive CD4 + T cells. Importantly, Hdac4/7 are functionally dispensable in other Th subtypes. Mechanistically, Hda...
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作者：Jun, Kyujung; Lee, Byungju; Kam, Ronald L.; Ceder, Gerbrand
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Korea Institute of Science & Technology (KIST)
摘要：Since the 1980s, the paddlewheel effect has been suggested as a mechanism to boost lithium- ion diffusion in inorganic materials via the rotation of rotor- like anion groups. However, it remains unclear whether the paddlewheel effect, defined as large- angle anion group rotations assisting Li hopping, indeed exists; furthermore, the physical mechanism by which the anion- group dynamics affect lithium- ion diffusion has not yet been established. In this work, we differentiate various types of r...
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作者：Li, Michael Y.; Chong, Lauren C.; Duns, Gerben; Lytle, Andrew; Woolcock, Bruce; Jiang, Aixiang; Telenius, Adele; Ben-Neriah, Susana; Nawaz, Waqas; Slack, Graham W.; Elisia, Ingrid; Vigano, Elena; Aoki, Tomohiro; Healy, Shannon; Krystal, Gerald; Venturutti, Leandro; Scott, David W.; Steidl, Christian
作者单位：University of British Columbia
摘要：Here, we report recurrent focal deletions of the chr14q32.31 - 32 locus, including TRAF3 , a negative regulator of NF -K B signaling, in de novo diffuse large B cell lymphoma (DLBCL) (24/324 cases). Integrative analysis revealed an association between TRAF3 copy number loss with accumulation of NIK, the central noncanonical (NC) NF -K B kinase, and increased NC NF -K B pathway activity. Accordingly, TRAF3 genetic ablation in isogenic DLBCL model systems caused upregulation of NIK and enhanced ...
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作者：Feng, Xin; Ye, Yongyu; Zhang, Jianan; Zhang, Yuanqiang; Zhao, Sen; Mak, Judith C. W.; Otomo, Nao; Zhao, Zhengye; Niu, Yuchen; Yonezawa, Yoshiro; Li, Guozhuang; Lin, Mao; Li, Xiaoxin; Cheung, Prudence Wing Hang; Xu, Kexin; Takeda, Kazuki; Wang, Shengru; Xie, Junjie; Kotani, Toshiaki; Choi, Vanessa N. T.; Song, You-Qiang; Yang, Yang; Luk, Keith Dip Kei; Lee, Kin Shing; Li, Ziquan; Li, Pik Shan; Leung, Connie Y. H.; Lin, Xiaochen; Wang, Xiaolu; Qiu, Guixing; Watanabe, Kota; Wu, Zhihong; Posey, Jennifer E.; Ikegawa, Shiro; Lupski, James R.; Cheung, Jason Pui Yin; Zhang, Terry Jianguo; Gao, Bo; Wu, Nan
作者单位：Chinese University of Hong Kong; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; University of Hong Kong; Guangdong Academy of Medical Sciences & Guangdong General Hospital; Southern Medical University - China; University of Hong Kong; Shandong University; University of Hong Kong; Keio University; RIKEN; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Zhejiang University; University of Hong Kong; University of Hong Kong; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; University of Hong Kong; Chinese University of Hong Kong
摘要：Congenital scoliosis (CS), affecting approximately 0.5 to 1 in 1,000 live births, is commonly caused by congenital vertebral malformations (CVMs) arising from aberrant somitogenesis or somite differentiation. While Wnt/ss - catenin signaling has been implicated in somite development, the function of Wnt/planar cell polarity (Wnt/PCP) signaling in this process remains unclear. Here, we investigated the role of Vangl1 and Vangl2 in vertebral development and found that their deletion causes verte...
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作者：Puy, Andreu; Gimeno, Elisabet; Torrents, Jordi; Bartashevich, Palina; Miguel, M. Carmen; Pastor-Satorras, Romualdo; Romanczuk, Pawel
作者单位：Universitat Politecnica de Catalunya; University of Barcelona; Humboldt University of Berlin; Technical University of Berlin; University of Barcelona
摘要：Animals moving together in groups are believed to interact among each other with effective social forces, such as attraction, repulsion, and alignment. Such forces can be inferred using force maps, i.e., by analyzing the dependency of the acceleration of a focal individual on relevant variables. Here, we introduce a force map technique suitable for the analysis of the alignment forces experienced by individuals. After validating it using an agent -based model, we apply the force map to experim...
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作者：Ugalde, Paula C.; Joly, Delphine; Latorre, Claudio; Gayo, Eugenia M.; Labarca, Rafael; Simunovic, Mikhaela; Mcrostie, Virginia; Holliday, Vance T.; Quade, Jay; Santoro, Calogero M.
作者单位：Universidad Alberto Hurtado; Universidad de Tarapaca; Pontificia Universidad Catolica de Chile; Universidad de Chile; Pontificia Universidad Catolica de Chile; University of Arizona; University of Arizona
摘要：In deserts, water has been singled out as the most important factor for choosing where to settle, but trees were likely an important part of the landscape for hunter - gatherers beyond merely constituting an economic resource. Yet, this critical aspect has not been considered archaeologically. Here, we present the results of mapping and radiocarbon dating of a truly unique archaeological record. Over 150 preserved stumps around five Late Pleistocene/ Early Holocene archaeological campsites (12...
