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作者：Bakiri, Latifa; Hasenfuss, Sebastian C.; Guio-Carrion, Ana; Thomsen, Martin K.; Hasselblatt, Peter; Wagner, Erwin F.
作者单位：Medical University of Vienna; Aarhus University; Medical University of Vienna; Beam Therapeutics, Inc.; Centro Nacional de Investigaciones Cardiovasculares (CNIC)
摘要：Hepatocellular carcinoma (HCC) is a leading cause of cancer - related death. HCC incidence is on the rise, while treatment options remain limited. Thus, a better understanding of the molecular pathways involved in HCC development has become a priority to guide future therapies. While previous studies implicated the Activator Protein - 1 (AP - 1) (Fos/Jun) transcription factor family members c - Fos and c - Jun in HCC formation, the contribution of Fos - related antigens (Fra - ) 1 and 2 is unk...
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作者：Quintero, Ignacio
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS)
摘要：Rates of evolution are fundamental to understand the processes that shaped the history of life. The predominant view holds that high rates of phenotypic evolution result from lineage transitions across peaks in an adaptive landscape, with subsequent slowdowns, but evidence remains debated. I developed a phylogenetic diffused Brownian motion model that characterizes nuanced variations in evolutionary rates and use it to comprehensively assess body size evolution and its underlying rates for 2,9...
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作者：Gao, Cheng Frank; Vaikuntanathan, Suriyanarayanan; Riesenfeld, Samantha J.
作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago
摘要：RNA velocity estimation is a potentially powerful tool to reveal the directionality of transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, absent advanced metabolic labeling techniques. We developed an approach, TopicVelo, that disentangles simultaneous, yet distinct, dynamics by using a probabilistic topic model, a highly interpretable form of latent space factorization, to infer cells and genes associated with individual processes, thereby capturing cellular pl...
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作者：Rojo, Daniela; Hael, Clara E.; Soria, Agustina; de Souza, Flavio S. J.; Low, Malcolm J.; Franchini, Lucia F.; Rubinstein, Marcelo
作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Michigan System; University of Michigan; Stanford University
摘要：Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( POMC) gene. In mammals, arcuate - specific POMC expression is driven by two cis - acting transcriptional enhancers known as nPE1 and nPE2. Because mutant mice lacking these two enhancers still showed hypothalamic Pomc mRNA, we searched for additional elements contributing to arcuate Pomc expression. By combining molecular evolution with reporter gene expression i...
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作者：Li, Yanning; Jenn, Alan
作者单位：University of California System; University of California Davis
摘要：California, a pioneer in EV adoption, has enacted ambitious electric vehicle (EV) policies that will generate a large burden on the state's electric distribution system. We investigate the statewide impact of uncontrolled EV charging on the electric distribution networks at a large scale and high granularity, by employing an EV charging profile projection that combines travel demand model, EV adoption model, and real - world EV charging data. We find a substantial need for infrastructure upgra...
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作者：Ranjan, Rajeev; Srijan, Sonali; Balekuttira, Somaiah; Agarwal, Tina; Ramey, Melissa; Dobbins, Madison; Kuhn, Rachel; Wang, Xiaojin; Hudson, Karen; Li, Ying; Varala, Kranthi
作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; United States Department of Agriculture (USDA)
摘要：Organ - specific gene expression datasets that include hundreds to thousands of experiments allow the reconstruction of organ - level gene regulatory networks (GRNs). However, creating such datasets is greatly hampered by the requirements of extensive and tedious manual curation. Here, we trained a supervised classification model that can accurately classify the organ - of - origin for a plant transcriptome. This K - Nearest Neighbor - based multiclass classifier was used to create organ - spe...
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作者：Zhang, Zhibo; Zhang, Shan; Wang, Qing; Lu, Anliang; Chen, Zhaoqi; Yang, Ziyin; Luan, Junhua; Su, Rui; Guan, Pengfei; Yang, Yong
作者单位：City University of Hong Kong; Chinese Academy of Engineering Physics; Beijing Computational Science Research Center (CSRC); Shanghai University; City University of Hong Kong; Hangzhou Dianzi University
摘要：Traditional metallic glasses (MGs), based on one or two principal elements, are notoriously known for their lack of tensile ductility at room temperature. Here, we developed a multiprincipal element MG (MPEMG), which exhibits a gigapascal yield strength, significant strain hardening that almost doubles its yield strength, and 2% uniform tensile ductility at room temperature. These remarkable properties stem from the heterogeneous amorphous structure of our MPEMG, which is composed of atoms wit...
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作者：Calvin, Jason J.; Brewer, Amanda S.; Crook, Michelle F.; Kaufman, Tierni M.; Alivisatos, Paul
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Surface energy is a fundamental property of materials and is particularly important in describing nanomaterials where atoms or molecules at the surface constitute a large fraction of the material. Traditionally, surface energy is considered to be a positive quantity, where atoms or molecules at the surface are less thermodynamically stable than their counterparts in the interior of the material because they have fewer bonds or interactions at the surface. Using calorimetric methods, we show th...
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作者：Lv, Guangxin; Tu, Yaodong; Zhang, James H.
作者单位：Massachusetts Institute of Technology (MIT)
摘要：Although water is almost transparent to visible light, we demonstrate that the air-water interface interacts strongly with visible light via what we hypothesize as the photomolecular effect. In this effect, transverse - magnetic polarized photons cleave off water clusters from the air-water interface. We use 14 different experiments to demonstrate the existence of this effect and its dependence on the wavelength, incident angle, and polarization of visible light. We further demonstrate that vi...
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作者：Charbonneau, Joey A.; Santistevan, Anthony C.; Raven, Erika P.; Bennett, Jeffrey L.; Russ, Brian E.; Bliss-Moreau, Eliza
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; New York University; University of California System; University of California Davis; California State University System; California State University Sacramento; Nathan Kline Institute for Psychiatric Research; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; New York University
摘要：Affective touch-a slow, gentle, and pleasant form of touch-activates a different neural network than which is activated during discriminative touch in humans. Affective touch perception is enabled by specialized low-threshold mechanoreceptors in the skin with unmyelinated fibers called C tactile (CT) afferents. These CT afferents are conserved across mammalian species, including macaque monkeys. However, it is unknown whether the neural representation of affective touch is the same across spec...
