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作者：Doherty, Tim S.; Macdonald, Kristina J.; Nimmo, Dale G.; Santos, Julianna L.; Geary, William L.; Bowman, David
作者单位：University of Sydney; Deakin University; Charles Sturt University; Charles Sturt University; University of Melbourne
摘要：Human actions are causing widespread increases in fire size, frequency, and severity in diverse ecosystems globally. This alteration of fire regimes is considered a threat to numerous animal species, but empirical evidence of how fire regimes are shifting within both threatened species' ranges and protected areas is scarce, particularly at large spatial and temporal scales. We used a big data approach to quantify multidecadal changes in fire regimes in southern Australia from 1980 to 2021, spa...
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作者：Goodson, Boyd M.; Chekmenev, Eduard Y.
作者单位：Southern Illinois University System; Southern Illinois University; Southern Illinois University System; Southern Illinois University; Wayne State University; Barbara Ann Karmanos Cancer Institute
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作者：Firouzbakht, Arash; Haider, Austin; Gaalswyk, Kari; Alaeen, Sepehr; Ghosh, Kingshuk; Gruebele, Martin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Denver; University of Denver; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Intrinsically disordered proteins (IDPs) that lie close to the empirical boundary separating IDPs and folded proteins in Uversky's charge-hydropathy plot may behave as marginal IDPs and sensitively switch conformation upon changes in environment (temperature, crowding, and charge screening), sequence, or both. In our search for such a marginal IDP, we selected Huntingtin - interacting protein K (HYPK) near that boundary as a candidate; PKI alpha , also near that boundary, has lower secondary s...
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作者：Terada, Yu; Toyoizumi, Taro
作者单位：RIKEN; University of California System; University of California San Diego; University of Tokyo; University of Tokyo
摘要：Cortical neurons exhibit highly variable responses over trials and time. Theoretical works posit that this variability arises potentially from chaotic network dynamics of recurrently connected neurons. Here, we demonstrate that chaotic neural dynamics, formed through synaptic learning, allow networks to perform sensory cue integration in a sampling -based implementation. We show that the emergent chaotic dynamics provide neural substrates for generating samples not only of a static variable bu...
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作者：Kosc, Thomas; Kuperberg, Denis; Rajon, Etienne; Charlat, Sylvain
作者单位：VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS)
摘要：Autocatalysis is seen as a potential key player in the origin of life, and perhaps more generally in the emergence of Darwinian dynamics. Building on recent formalizations of this phenomenon, we tackle the computational challenge of exhaustively detecting minimal autocatalytic cycles (autocatalytic cores) in reaction networks and further evaluate the impact of thermodynamic constraints on their realization under mass action kinetics. We first characterize the complexity of the detection proble...
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作者：Sherman, David J.; Liu, Lei; Mamrosh, Jennifer L.; Xie, Jiansong; Ferbas, John; Lomenick, Brett; Ladinsky, Mark S.; Verma, Rati; Rulifson, Ingrid C.; Deshaies, Raymond J.
作者单位：California Institute of Technology; California Institute of Technology; United States Department of Energy (DOE); Los Alamos National Laboratory
摘要：Nonalcoholic fatty liver disease, recently renamed metabolic dysfunction - associated steatotic liver disease (MASLD), is a progressive metabolic disorder that begins with aberrant triglyceride accumulation in the liver and can lead to cirrhosis and cancer. A common variant in the gene PNPLA3 , encoding the protein PNPLA3 - I148M, is the strongest known genetic risk factor for MASLD. Despite its discovery 20 y ago, the function of PNPLA3, and now the role of PNPLA3 - I148M, remain unclear. In ...
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作者：Aldahabi, Mohammad; Neher, Erwin; Nusser, Zoltan
作者单位：Semmelweis University
摘要：Pronounced differences in neurotransmitter release from a given presynaptic neuron, depending on the synaptic target, are among the most intriguing features of cortical networks. Hippocampal pyramidal cells (PCs) release glutamate with low probability to somatostatin expressing oriens-lacunosum-moleculare (O-LM) interneurons (INs), and the postsynaptic responses show robust short-term facilitation, whereas the release from the same presynaptic axons onto fast-spiking INs (FSINs) is similar to ...
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作者：Berenbaum, May R.; Thorp, H. Holden
作者单位：Harvard University
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作者：Hou, Dan; Yu, Tao; Lu, Xuan; Hong, Jun Young; Yang, Min; Zi, Yanlin; Ho, Thanh Tu; Lin, Hening
作者单位：University of California System; University of California San Francisco
摘要：Sirt2 is a nicotinamide adenine dinucleotide (NAD + ) - dependent protein lysine deacylase that can remove both acetyl group and long - chain fatty acyl groups from lysine residues of many proteins. It was reported to affect inflammatory bowel disease (IBD) symptoms in a mouse model. However, conflicting roles were reported, with genetic knockout aggravating while pharmacological inhibition alleviating IBD symptoms. These seemingly conflicting reports cause confusion and deter further efforts ...
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作者：Ng, Anita; Lovat, Francesca; Shih, Andrew J.; Ma, Yuhong; Pekarsky, Yuri; DiCaro, Frank; Crichton, Lita; Sharma, Esha; Yan, Xiao Jie; Sun, Daqian; Song, Tengfei; Zou, Yong- Rui; Will, Britta; Croce, Carlo M.; Chiorazzi, Nicholas
