-
作者：Hasyim, Muhammad R.; Mandadapu, Kranthi K.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：In supercooled liquids, dynamical facilitation refers to a phenomenon where microscopic motion begets further motion nearby, resulting in spatially heterogeneous dynamics. This is central to the glassy relaxation dynamics of such liquids, which show super-Arrhenius growth of relaxation timescales with decreasing temperature. Despite the importance of dynamical facilitation, there is no theoretical understanding of how facilitation emerges and impacts relaxation dynamics. Here, we present a the...
-
作者：Peng, Yu- chih; Wu, Jian; He, Xiao; Dai, Jin; Xia, Lu; Valenzuela-Leon, Paola; Tumas, Keyla C.; Singh, Brajesh K.; Xu, Fangzheng; Ganesan, Sundar; Munir, Shirin; Calvo, Eric; Huang, Ruili; Liu, Chengyu; Long, Carole A.; Su, Xin-zhuan
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Central South University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
摘要：Olfactory receptors (Olfr) are G protein-coupled receptors that are normally expressed on olfactory sensory neurons to detect volatile chemicals or odorants. Interestingly, many Olfrs are also expressed in diverse tissues and function in cell-cell recognition, migration, and proliferation as well as immune responses and disease processes. Here, we showed that many Olfr genes were expressed in the mouse spleen, linked to Plasmodium yoelii genetic loci significantly, and/or had genome - wide pat...
-
作者：Xia, Qiancheng; Deng, Zehui; Sun, Siwei; Zhao, Wei; Ding, Jie; Xi, Beidou; Gao, Guandao; Wang, Chao
作者单位：Nanjing University; Yangzhou University; Nanjing University; Chinese Research Academy of Environmental Sciences; Nanjing University
摘要：Lithium is an emerging strategic resource for modern energy transformation toward electrification and decarbonization. However, current mainstream direct lithium extraction technology via adsorption suffers from sluggish kinetics and intensive water usage, especially in arid/semiarid and cold salt-lake regions (natural land brines). Herein, an efficient proof-of-concept integrated solar microevaporator system is developed to realize synergetic solar-enhanced lithium recovery and water footprin...
-
作者：Yang, Cheng; Ma, Shuxiang; Zhang, Jie; Han, Yuchen; Wan, Li; Zhou, Wenlong; Dong, Xiaoyu; Yang, Weiming; Chen, Yu; Gao, Lingyue; Cui, Wei; Jia, Lina; Yang, Jingyu; Wu, Chunfu; Wang, Qiming; Wang, Lihui
作者单位：Shenyang Pharmaceutical University; Shenyang Pharmaceutical University; Zhengzhou University; Zhengzhou University
摘要：The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) is a recognized resistance mechanism and a hindrance to therapies using epidermal growth factor receptor tyrosine kinase inhibitors (TKIs). The paucity of pretranslational/posttranslational clinical samples limits the deeper understanding of resistance mechanisms and the exploration of effective therapeutic strategies. Here, we developed preclinical neuroendocrine (NE) transformation models. Next, we identified a transc...
-
作者：Clark, Hailey; Ravesteijn, Bastian; Mullen, Kathleen J.; Maestas, Nicole
作者单位：Harvard University; Harvard Medical School; Erasmus University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam; University of Oregon; University of Southern California; National Bureau of Economic Research
摘要：This research paper investigates the prevalence of functional limitations among employed adults in the United States and the association between these limitations and medical conditions. The authors administered a survey adapted from the Dutch Functional Abilities List to a nationally representative sample of US adults ages 22 and older, finding that nearly three-quarters of working adults report at least one functional limitation, with an average of nearly six functional limitations per worki...
-
作者：England, Sam J.; Robert, Daniel
作者单位：University of Bristol
摘要：Predators and prey benefit from detecting sensory cues of each other's presence. As they move through their environment, terrestrial animals accumulate electrostatic charge. Because electric charges exert forces at a distance, a prey animal could conceivably sense electrical forces to detect an approaching predator. Here, we report such a case of a terrestrial animal detecting its predators by electroreception. We show that predatory wasps are charged, thus emit electric fields, and that cater...
-
作者：Koncz, Balazs; Balogh, Gergo Mihaly; Manczinger, Mate
作者单位：HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Szeged University
摘要：The identification of immunogenic peptides has become essential in an increasing number of fields in immunolo - gy, ranging from tumor immunotherapy to vaccine devel - opment. The nature of the adaptive immune response is shaped by the similarity between foreign and selfprotein sequences, a concept extensively applied in numerous stud - ies. Can we precisely define the degree of similarity to self? Furthermore, do we accurately define immune self? In the current work, we aim to unravel the con...
-
作者：Cadena, Carlos Daniel
作者单位：Universidad de los Andes (Colombia)
-
作者：Rubin, Nicholas C.; Berry, Dominic W.; Kononov, Alina; Malone, Fionn D.; Khattar, Tanuj; White, Alec; Lee, Joonho; Neven, Hartmut; Babbush, Ryan; Baczewski, Andrew D.
作者单位：Alphabet Inc.; Google Incorporated; Macquarie University; United States Department of Energy (DOE); Sandia National Laboratories; Harvard University
摘要：Stopping power is the rate at which a material absorbs the kinetic energy of a charged particle passing through it-one of many properties needed over a wide range of thermodynamic conditions in modeling inertial fusion implosions. First -principles stopping calculations are classically challenging because they involve the dynamics of large electronic systems far from equilibrium, with accuracies that are particularly difficult to constrain and assess in the warm -dense conditions preceding ign...
-
作者：Zhang, Shaoshi; Larsen, Bart; Sydnor, Valerie J.; Zeng, Tianchu; An, Lijun; Yan, Xiaoxuan; Kong, Ru; Kong, Xiaolu; Gur, Ruben C.; Gur, Raquel E.; Moore, Tyler M.; Wolf, Daniel H.; Holmes, Avram J.; Xie, Yapei; Zhou, Juan Helen; Fortier, Marielle V.; Tan, Ai Peng; Gluckman, Peter; Chong, Yap Seng; Meaney, Michael J.; Deco, Gustavo; Satterthwaite, Theodore D.; Yeo, B. T. Thomas
作者单位：National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Minnesota System; University of Minnesota Twin Cities; University of Pennsylvania; Rutgers University System; Rutgers University New Brunswick; Yale University; KK Women's & Children's Hospital; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences (SICS); National University of Singapore; University of Auckland; National University of Singapore; McGill University; University of Barcelona; Pompeu Fabra University; ICREA; University of Barcelona; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：A balanced excitation- inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex- wide E/I ratio remains unknown. Here, we noninvasively estimate a putative marker of whole- cortex E/I ratio by fitting a large- scale biophysically plausible circuit model to resting- state functional MRI (fMRI) data. We first confirm that our model generates realistic brain dynamics in the Human Connectome Project. Next, we show that the estimated E/I ratio marker is s...
