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作者：Machado, Carla Botelho; Marsh, Robert; Hargreaves, Jessica K.; Oxenford, Hazel A.; Maddix, Gina-Marie; Webber, Dale F.; Webber, Mona; Tonon, Thierry
作者单位：University of York - UK; University of Southampton; NERC National Oceanography Centre; University of York - UK; University West Indies Mona Jamaica; University West Indies Cave Hill Campus; University West Indies Mona Jamaica; University West Indies Mona Jamaica
摘要：The year 2021 marked a decade of holopelagic sargassum (morphotypes Sargassum natans I and VIII, and Sargassum fluitans III) stranding on the Caribbean and West African coasts. Beaching of millions of tons of sargassum negatively impacts coastal ecosystems, economies, and human health. Additionally, the La Soufri & egrave;re volcano erupted in St. Vincent in April 2021, at the start of the sargassum season. We investigated potential monthly variations in morphotype abundance and biomass compos...
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作者：Wang, Dianzhuo; Huot, Marian; Mohanty, Vaibhav; Shakhnovich, Eugene I.; Sali, Andrej
作者单位：Harvard University; Harvard University; Institut Polytechnique de Paris; Ecole Polytechnique; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT)
摘要：SARS-CoV-2 employs its spike protein's receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. However, our understanding of how RBD's biophysical properties contribute to SARS-CoV-2's epidemiological fitness remains largely incomplete. Through a comprehensive approach, comprising large-scale sequence analysis of SARS-CoV-2 variants and the identification of a fitn...
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作者：Comita, Liza S.; Jones, F. Andrew; Manzane-Pinzon, Eric J.; Alvarez-Cansino, Leonor; Ceron-Souza, Ivania; Contreras, Blexein; Jaen-Barrios, Nelson; Ferro, Natalie; Engelbrecht, Bettina M. J.
作者单位：Yale University; Smithsonian Institution; Smithsonian Tropical Research Institute; Oregon State University; Universidad Tecnologica de Panama; University of Sevilla; University of Bayreuth; Corporacion Colombiana de Investigacion Agropecuaria, AGROSAVIA; Universidade Estadual de Campinas; Universidade de Sao Paulo
摘要：Assessing within - species variation in response to drought is crucial for predicting species' responses to climate change and informing restoration and conservation efforts, yet experimental data are lacking for the vast majority of tropical tree species. We assessed intraspecific variation in response to water availability across a strong rainfall gradient for 16 tropical tree species using reciprocal transplant and common garden field experiments, along with measurements of gene flow and ke...
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作者：Huang, Yingyu; Yu, Mengxiao; Zheng, Jie
作者单位：University of Texas System; University of Texas Dallas
摘要：The renal elimination pathway is increasingly harnessed to reduce nonspecific accumulation of engineered nanoparticles within the body and expedite their clinical applications. While the size of nanoparticles is recognized as crucial for their passive filtration through the glomerulus due to its limited pore size, the influence of nanoparticle charge on their transport and interactions within the kidneys remains largely elusive. Herein, we report that the proximal tubule and peritubular capill...
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作者：Nebo, Ikenna David; Frew, John W.; Gudjonsson, Johann E.; Petukhova, Lynn
作者单位：Columbia University; Ingham Institute for Applied Medical Research; University of New South Wales Sydney; Liverpool Hospital; University of Michigan System; University of Michigan; New York University; New York University
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作者：Zhang, Bidong; Chabot, Nancy L.; Rubin, Alan E.
作者单位：University of California System; University of California Los Angeles; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory
摘要：Magmatic iron - meteorite parent bodies are the earliest planetesimals in the Solar System, and they preserve information about conditions and planet - forming processes in the solar nebula. In this study, we include comprehensive elemental compositions and fractional - crystallization modeling for iron meteorites from the cores of five differentiated asteroids from the inner Solar System. Together with previous results of metallic cores from the outer Solar System, we conclude that asteroidal...
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作者：Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Gronroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Oresic, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
作者单位：University of Turku; Abo Akademi University; University of Turku; Orebro University; Stanford University; University of Turku
摘要：Regulatory T cells (Tregs) are central in controlling immune responses, and dysregulation of their function can lead to autoimmune disorders or cancer. Despite extensive studies on Tregs, the basis of epigenetic regulation of human Treg development and function is incompletely understood. Long intergenic noncoding RNAs (lincRNA)s are important for shaping and maintaining the epigenetic landscape in different cell types. In this study, we identified a gene on the chromosome 6p25.3 locus, encodi...
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作者：Hardcastle, Matthew
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作者：Liu, Qiao; Chen, Zhongren; Wong, Wing Hung
作者单位：Stanford University; Stanford University; Yale University; Stanford University
摘要：In this article, we develop CausalEGM, a deep learning framework for nonlinear dimension reduction and generative modeling of the dependency among covariate features affecting treatment and response. CausalEGM can be used for estimating causal effects in both binary and continuous treatment settings. By learning a bidirectional transformation between the high-dimensional covariate space and a low-dimensional latent space and then modeling the dependencies of different subsets of the latent var...
