23期

最新文章

• RNA tailing machinery drives amyloidogenic phase transition AI翻译
  作者：Bokros, Michael; Balukoff, Nathan C.; Grunfeld, Alex; Sebastiao, Mathew; Beurel, Eleonore; Bourgault, Steve; Lee, Stephen
  作者单位：University of Miami; University of Miami; University of Quebec; University of Quebec Montreal; University of Miami
  摘要：The RNA tailing machinery adds nucleotides to the 3 '- end of RNA molecules that are implicated in various biochemical functions, including protein synthesis and RNA stability. Here, we report a role for the RNA tailing machinery as enzymatic modifiers intracellular amyloidogenesis. A targeted RNA interference screen identified Terminal Nucleotidyl - transferase 4b (TENT4b/Papd5) as an essential participant in the amyloidogenic phase transition of nucleoli into solid - like Amyloid bodies. Ful...
• Phosphorylation of DNA- binding domains of CLOCK-BMAL1 complex for PER- dependent inhibition in circadian clock of mammalian cells AI翻译
  作者：Otobe, Yuta; Jeong, Eui Min; Ito, Shunsuke; Shinohara, Yuta; Kurabayashi, Nobuhiro; Aiba, Atsu; Fukada, Yoshitaka; Kim, Jae Kyoung; Yoshitane, Hikari
  作者单位：University of Tokyo; Tokyo Metropolitan Institute of Medical Science; Institute for Basic Science - Korea (IBS); Korea Advanced Institute of Science & Technology (KAIST); Hokkaido University; Hokkaido University; University of Tokyo
  摘要：In mammals, CLOCK and BMAL1 proteins form a heterodimer that binds to E - box sequences and activates transcription of target genes, including Period ( Per) . Translated PER proteins then bind to the CLOCK-BMAL1 complex to inhibit its transcriptional activity. However, the molecular mechanism and the impact of this PER - dependent inhibition on the circadian clock oscillation remain elusive. We previously identified Ser38 and Ser42 in a DNA - binding domain of CLOCK as phosphorylation sites at...
• Weaponizing the bystander T cell army to fight tuberculosis AI翻译
  作者：Cohen, Sara B.; Urdahl, Kevin B.
  作者单位：Seattle Children's Hospital; University of Washington; University of Washington Seattle
• Natural history of eukaryotic DNA viruses with double jelly- roll major capsid proteins AI翻译
  作者：Krupovic, Mart; Kuhn, Jens H.; Fischer, Matthias G.; V. Koonin, Eugene; Redrejo, Modesto
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Max Planck Society; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
  摘要：The phylum Preplasmiviricota (kingdom Bamfordvirae , realm Varidnaviria ) is a broad assemblage of diverse viruses with comparatively short double - stranded DNA genomes (<50 kbp) that produce icosahedral capsids built from double jelly - roll major capsid proteins. Preplasmiviricots infect hosts from all cellular domains, testifying to their ancient origin, and, in particular, are associated with six of the seven supergroups of eukaryotes. Preplasmiviricots comprise four major groups of virus...
• Metamagnetic multiband Hall effect in Ising antiferromagnet ErGa2 AI翻译
  作者：Kurumaji, Takashi; Fang, Shiang; Ye, Linda; Kitou, Shunsuke; Checkelsky, Joseph G.
  作者单位：Massachusetts Institute of Technology (MIT); Rutgers University System; Rutgers University New Brunswick; University of Tokyo
  摘要：Frustrated rare - earth - based intermetallics provide a promising platform for emergent magnetotransport properties through exchange coupling between conduction electrons and localized rare - earth magnetic moments. Metamagnetism, the abrupt change of magnetization under an external magnetic field, is a signature of first - order magnetic phase transitions; recently, metamagnetic transitions in frustrated rare earth intermetallics have attracted interest for their accompanying nontrivial spin...
• CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion-GRB2-SHC1 signal niche AI翻译
  作者：Qiu, Ting; Kong, Yichao; Wei, Guifeng; Sun, Kai; Wang, Ruijie; Wang, Yang; Chen, Yiji; Wang, Wenxin; Zhang, Yun; Jiang, Caihong; Yang, Peiguo; Xie, Tian; Chen, Xiabin
  作者单位：Hangzhou Normal University; Hangzhou Normal University; Hangzhou Normal University; Hangzhou Normal University; Westlake University
  摘要：Rearranged during transfection (RET) rearrangement oncoprotein - mediated Ras/ MAPK signaling cascade is constitutively activated in cancers. Here, we demonstrate a unique signal niche. The niche is a ternary complex based on the chimeric RET liquid- liquid phase separation. The complex comprises the rearranged kinase (RET fusion); the adaptor (GRB2), and the effector (SHC1). Together, they orchestrate the Ras/ MAPK signal cascade, which is dependent on tyrosine kinase. CCDC6 - RET fusion unde...
• Growth couples temporal and spatial fluctuations of tissue properties during morphogenesis AI翻译
  作者：Fruleux, Antoine; Hong, Lilan; Roeder, Adrienne H. K.; Li, Chun-Biu; Boudaoud, Arezki
  作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); INRAE; Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); Institut Polytechnique de Paris; Ecole Polytechnique; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Zhejiang University; Cornell University; Cornell University; Stockholm University
  摘要：Living tissues display fluctuations-random spatial and temporal variations of tissue properties around their reference values-at multiple scales. It is believed that such fluctuations may enable tissues to sense their state or their size. Recent theoretical studies developed specific models of fluctuations in growing tissues and predicted that fluctuations of growth show long-range correlations. Here, we elaborated upon these predictions and we tested them using experimental data. We first int...
• Electroluminescent vertical tunneling junctions based on WSe 2 monolayer quantum emitter arrays: Exploring tunability with electric and magnetic fields AI翻译
  作者：Howarth, James; Vaklinova, Kristina; Grzeszczyk, Magdalena; Baldi, Giulio; Hague, Lee; Potemski, Marek; Novoselov, Kostya S.; Kozikov, Aleksey; Koperski, Maciej
  作者单位：University of Manchester; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National des Sciences Appliquees de Toulouse; Polish Academy of Sciences; Institute of High Pressure Physics of the Polish Academy of Sciences; National University of Singapore; Newcastle University - UK
  摘要：We experimentally demonstrate the creation of defects in monolayer WSe 2 via nanopillar imprinting and helium ion irradiation. Based on the first method, we realize atomically thin vertical tunneling light -emitting diodes based on WSe 2 monolayers hosting quantum emitters at deterministically specified locations. We characterize these emitters by investigating the evolution of their emission spectra in external electric and magnetic fields, as well as by inducing electroluminescence at low te...
• Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2 AI翻译
  作者：Liang, Shiyu; Liu, Aijun; Liu, Yezhou; Wang, Fuxing; Zhou, Youli; Long, Yuanzhengyang; Wang, Tao; Liu, Zheng; Ren, Ruobing; Ye, Richard D.
  作者单位：The Chinese University of Hong Kong, Shenzhen; Shenzhen Bay Laboratory; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Fudan University; The Chinese University of Hong Kong, Shenzhen
  摘要：Essential for reactive oxygen species (EROS) protein is a recently identified molecular chaperone of NOX2 (gp91 phox ), the catalytic subunit of phagocyte NADPH oxidase. Deficiency in EROS is a recently identified cause for chronic granulomatous disease, a genetic disorder with recurrent bacterial and fungal infections. Here, we report a cryo - EM structure of the EROS-NOX2-p22 phox heterotrimeric complex at an overall resolution of 3.56 & Aring;. EROS and p22 phox are situated on the opposite...
• Prebiotic chemical reactivity in solution with quantum accuracy and microsecond sampling using neural network potentials AI翻译
  作者：Benayad, Zakarya; David, Rolf; Stirnemann, Guillaume
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite PSL; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Ecole Normale Superieure (ENS)
  摘要：While RNA appears as a good candidate for the first autocatalytic systems preceding the emergence of modern life, the synthesis of RNA oligonucleotides without enzymes remains challenging. Because the uncatalyzed reaction is extremely slow, experimental studies bring limited and indirect information on the reaction mechanism, the nature of which remains debated. Here, we develop neural network potentials (NNPs) to study the phosphoester bond formation in water. While NNPs are becoming routinel...