23期

最新文章

• Albatrosses employ orientation and routing strategies similar to yacht racers AI翻译
  作者：Goto, Yusuke; Weimerskirch, Henri; Fukaya, Keiichi; Yoda, Ken; Naruoka, Masaru; Sato, Katsufumi
  作者单位：Nagoya University; La Rochelle Universite; National Institute for Environmental Studies - Japan; Japan Aerospace Exploration Agency (JAXA); University of Tokyo
  摘要：The way goal - oriented birds adjust their travel direction and route in response to wind significantly affects their travel costs. This is expected to be particularly pronounced in pelagic seabirds, which utilize a wind - dependent flight style called dynamic soaring. Dynamic soaring seabirds in situations without a definite goal, e.g. searching for prey, are known to preferentially fly with crosswinds or quartering - tailwinds to increase the speed and search area, and reduce travel costs. H...
• PVDF-HFP@Nafion-based quasisolid polymer electrolyte for high migration number in working rechargeable Na-O 2 batteries AI翻译
  作者：He, Xin; Ni, Youxuan; Ma, Wenjiao; Zhang, Qiu; Hao, Zhenkun; Hou, Yunpeng; Li, Haixia; Yan, Zhenhua; Zhang, Kai; Chen, Jun
  作者单位：Nankai University; Hunan University
  摘要：Rechargeable sodium - oxygen (Na-O 2 ) battery is deemed as a promising high - energy storage device due to the abundant sodium resources and high theoretical energy density (1,108 Wh kg -1 ). A series of quasisolid electrolytes are constantly being designed to restrain the dendrites growth, the volatile and leaking risks of liquid electrolytes due to the open system of Na-O 2 batteries. However, the ticklish problem about low operating current density for quasisolid electrolytes still hasn't ...
• Rapid detection of IDH mutations in gliomas by intraoperative mass spectrometry AI翻译
  作者：Hua, Wei; Zhang, Wenpeng; Brown, Hannah; Wu, Junhan; Fang, Xinqi; Shah, Mahdiyeh; Chen, Rong; Zhang, Haoyue; Jiao, Bin; Wang, Nan; Xu, Hao; Fu, Minjie; Wang, Xiaowen; Zhang, Jinsen; Zhang, Xin; Wang, Qijun; Zhu, Wei; Ye, Dan; Garcia, Diogo Moniz; Chaichana, Kaisorn; Cooks, R. Graham; Ouyang, Zheng; Mao, Ying; Hinojosa, Alfredo Quinones -
  作者单位：Fudan University; Fudan University; Tsinghua University; Purdue University System; Purdue University; Fudan University; Mayo Clinic
  摘要：The development and performance of two mass spectrometry (MS) workflows for the intraoperative diagnosis of isocitrate dehydrogenase (IDH) mutations in glioma is implemented by independent teams at Mayo Clinic, Jacksonville, and Huashan Hospital, Shanghai. The infiltrative nature of gliomas makes rapid diagnosis necessary to guide the extent of surgical resection of central nervous system (CNS) tumors. The combination of tissue biopsy and MS analysis used here satisfies this requirement. The k...
• Social competition drives collective action to reduce informal waste burning in Uganda AI翻译
  作者：Buntaine, Mark T.; Komakech, Polycarp; Shen, Shiran Victoria
  作者单位：University of California System; University of California Santa Barbara; Stanford University
  摘要：Improving urban air quality is a pressing challenge in the Global South. A key source of air pollution is the informal burning of household waste. Reducing informal burning requires governments to develop formal systems for waste disposal and for residents to adopt new disposal behaviors. Using a randomized experiment, we show that social competitions between pairs of neighborhoods in Nansana municipality, Uganda, galvanized leadership and inspired collective action to reduce informal burning....
• High prevalence of PRDM9-independent recombination hotspots in placental mammals AI翻译
  作者：Joseph, Julien; Prentout, Djivan; Laverre, Alexandre; Tricou, Theo; Duret, Laurent
  作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Columbia University; University of Lausanne; Swiss Institute of Bioinformatics
  摘要：In many mammals, recombination events are concentrated in hotspots directed by a sequence-specific DNA-binding protein named PRDM9. Intriguingly, PRDM9 has been lost several times in vertebrates, and notably among mammals, it has been pseudogenized in the ancestor of canids. In the absence of PRDM9, recombination hotspots tend to occur in promoter-like features such as CpG islands. It has thus been proposed that one role of PRDM9 could be to direct recombination away from PRDM9-independent hot...
• Primordial magnetotaxis in putative giant paleoproterozoic magnetofossils AI翻译
  作者：Bellon, Ualisson Donardelli; Williams, Wyn; Trindade, Ricardo Ivan Ferreira; Maldanis, Lara; Galante, Douglas
  作者单位：Universidade de Sao Paulo; University of Edinburgh; Vrije Universiteit Amsterdam; Universidade de Sao Paulo
  摘要：Magnetotactic bacteria produce chains of nanoscopic iron minerals used for navigation, which can be preserved over geological timescales in the form of magnetofossils. controlled mineralization have been found in the geological record and termed giant magnetofossils. The biological origin and function of giant magnetofossils remains unclear, due to the lack of modern analogues to giant magnetofossils. Using distinctive Ptychographic nanotomography data of Precambrian (1.88 Ga) rocks, we recove...
• Transient interactions modulate the affinity of NF-KB transcription factors for DNA AI翻译
  作者：Li, Tianjie; Shahabi, Shandy; Biswas, Tapan; V. Tsodikov, Oleg; Pan, Wenfei; Huang, De-Bin; Wang, Vivien Ya-Fan; Wang, Yi; Ghosh, Gourisankar
  作者单位：Chinese University of Hong Kong; University of California System; University of California San Diego; University of Kentucky; University of Macau
  摘要：The dimeric nuclear factor kappa B (NF - - K B) transcription factors (TFs) regulate gene expression by binding to a variety of -K B DNA elements with conserved G:C - rich flanking sequences enclosing a degenerate central region. Toward defining mechanistic principles of affinity regulated by degeneracy, we observed an unusual dependence of the affinity of RelA on the identity of the central base pair, which appears to be noncontacted in the complex crystal structures. The affinity of -K B sit...
• MTM1-mediated production of phosphatidylinositol 5-phosphate fuels the formation of podosome- like protrusions regulating myoblast fusion AI翻译
  作者：Mansat, Melanie; Kpotor, Afi Oportune; Chicanne, Gaetan; Picot, Melanie; Mazars, Anne; Flores- Flores, Remy; Payrastre, Bernard; Hnia, Karim; Viaud, Julien
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; CHU de Toulouse
  摘要：Myogenesis is a multistep process that requires a spatiotemporal regulation of cell events resulting finally in myoblast fusion into multinucleated myotubes. Most major insights into the mechanisms underlying fusion seem to be conserved from insects to mammals and include the formation of podosome - like protrusions (PLPs) that exert a driving force toward the founder cell. However, the machinery that governs this process remains poorly understood. In this study, we demonstrate that MTM1 is th...
• TMPRSS2-mediated SARS- CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution AI翻译
  作者：Qu, Bingqian; Miskey, Csaba; Goemer, Andre; Kleinert, Robin D. V.; Ibanez, Sara Calvo; Eberle, Regina; Ebenig, Aileen; Postmus, Dylan; Nocke, Maximilian K.; Herrmann, Maike; Itotia, Tabitha K.; Herrmann, Simon T.; Heinen, Natalie; Hoeck, Sebastian; Hastert, Florian D.; von Rhein, Christine; Schuermann, Christoph; Li, Xue; van Zandbergen, Ger; Widera, Marek; Ciesek, Sandra; Schnierle, Barbara S.; Tarr, Alexander W.; Steinmann, Eike; Goffinet, Christine; Pfaender, Stephanie; Locker, Jacomina Krijnse; Muehlebach, Michael D.; Todt, Daniel; Brown, Richard J. P.
  作者单位：Paul Ehrlich Institute; Paul Ehrlich Institute; Ruhr University Bochum; Paul Ehrlich Institute; Liverpool School of Tropical Medicine; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Paul Ehrlich Institute; University of Hamburg; University Medical Center Hamburg-Eppendorf; Ruprecht Karls University Heidelberg; Paul Ehrlich Institute; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Goethe University Frankfurt; Goethe University Frankfurt Hospital; German Center for Infection Research; University of Nottingham; University of Nottingham; University of Nottingham; University of Lubeck; German Center for Infection Research
  摘要：The accessory protease transmembrane protease serine 2 (TMPRSS2) enhances severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uptake into ACE2-expressing cells, although how increased entry impacts downstream viral and host processes remains unclear. To investigate this in more detail, we performed infection assays in engineered cells promoting ACE2-mediated entry with and without TMPRSS2 coexpression. Electron microscopy and inhibitor experiments indicated TMPRSS2-mediated cell entry...
• Recurrent flow patterns as a basis for two-dimensional turbulence: Predicting statistics from structures AI翻译
  作者：Page, Jacob; Norgaard, Peter; Brenner, Michael P.; Kerswell, Rich R.
  作者单位：University of Edinburgh; Alphabet Inc.; Google Incorporated; Harvard University; University of Cambridge
  摘要：A dynamical systems approach to turbulence envisions the flow as a trajectory through a high-dimensional state space [Hopf, Commun. Appl. Maths 1, 303 (1948)]. The chaotic dynamics are shaped by the unstable simple invariant solutions populating the inertial manifold. The hope has been to turn this picture into a predictive framework where the statistics of the flow follow from a weighted sum of the statistics of each simple invariant solution. Two outstanding obstacles have prevented this goa...