A journey to your self: The vague definition of immune self and its practical implications

• 成果类型: Article
• 署名作者: Koncz, Balazs; Balogh, Gergo Mihaly; Manczinger, Mate
• 署名单位: HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry - HAS; HUN-REN; HUN-REN Biological Research Center; Szeged University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9106
• DOI: 10.1073/pnas.2309674121
• 发表日期: 2024-06-04
• 关键词: mhc-class-i; regulatory t-cells; positive selection; cross-reactivity; co-stimulation; antigen; peptides; effector; binding; repertoire

摘要

The identification of immunogenic peptides has become essential in an increasing number of fields in immunolo - gy, ranging from tumor immunotherapy to vaccine devel - opment. The nature of the adaptive immune response is shaped by the similarity between foreign and selfprotein sequences, a concept extensively applied in numerous stud - ies. Can we precisely define the degree of similarity to self? Furthermore, do we accurately define immune self? In the current work, we aim to unravel the conceptual and mecha - nistic vagueness hindering the assessment of selfsimilarity. Accordingly, we demonstrate the remarkably low consist - ency among commonly employed measures and highlight potential avenues for future research.