23期

最新文章

• RNA polymerase tracking along damaged DNA: Impact on DNA repair and mutagenesis AI翻译
  作者：Chiou, Yi-Ying; Kemp, Michael G.
  作者单位：National Chung Hsing University; University System of Ohio; Wright State University Dayton
• Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race? AI翻译
  作者：Jin, Lin; Kashyap, Mahendra P.; Haque, Safiya T.; Li, Changzhao; Raman, Chander; Athar, Mohammad
  作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham
• The dominance and growth of shallow groundwater resources in continuous permafrost environments AI翻译
  作者：Koch, Joshua C.; Connolly, Craig T.; Baughman, Carson; Repasch, Marisa; Best, Heather; Hunt, Andrew
  作者单位：United States Department of the Interior; United States Geological Survey; University of Texas System; University of Texas Austin; University of Colorado System; University of Colorado Boulder; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; United States Geological Survey; United States Environmental Protection Agency
  摘要：Water is a limited resource in Arctic watersheds with continuous permafrost because freezing conditions in winter and the impermeability of permafrost limit storage and connectivity between surface water and deep groundwater. However, groundwater can still be an important source of surface water in such settings, feeding springs and large aufeis fields that are abundant in cold regions and generating runoff when precipitation is rare. Whether groundwater is sourced from suprapermafrost taliks ...
• Atomic resolution structure of full- length human insulin fibrils AI翻译
  作者：Suladze, Saba; Sarkar, Riddhiman; Rodina, Natalia; Bokvist, Krister; Krewinkel, Manuel; Scheps, Daniel; Nagel, Norbert; Bardiaux, Benjamin; Reif, Bernd
  作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Sanofi-Aventis; Sanofi Germany; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Neurocrine Biosciences; AbbVie
  摘要：Patients with type 1 diabetes mellitus who are dependent on an external supply of insulin develop insulin - derived amyloidosis at the sites of insulin injection. A major component of these plaques is identified as full - length insulin consisting of the two chains A and B. While there have been several reports that characterize insulin misfolding and the biophysical properties of the fibrils, atomic - level information on the insulin fibril architecture remains elusive. We present here an ato...
• Natural variation of immune epitopes reveals intrabacterial AI翻译
  作者：Stevens, Danielle M.; Moreno-Perez, Alba; Weisberg, Alexandra J.; Ramsing, Charis; Fliegmann, Judith; Zhang, Ning; Madrigal, Melanie; Martin, Gregory; Steinbrenner, Adam; Felix, Georg; Coaker, Gitta
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; Oregon State University; Eberhard Karls University of Tubingen; Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; University of Washington; University of Washington Seattle
  摘要：Plants and animals detect biomolecules termed microbe - associated molecular patterns (MAMPs) and induce immunity. Agricultural production is severely impacted by pathogens which can be controlled by transferring immune receptors. However, most studies use a single MAMP epitope and the impact of diverse multicopy MAMPs on immune induction is unknown. Here, we characterized the epitope landscape from five proteinaceous MAMPs across 4,228 plant - associated bacterial genomes. Despite the diversi...
• Principles of peptide selection by the transporter associated with antigen processing AI翻译
  作者：Lee, James; Oldham, Michael L.; Manon, Victor; Chen, Jue
  作者单位：Rockefeller University
  摘要：Our ability to fight pathogens relies on major histocompatibility complex class I (MHC - I) molecules presenting diverse antigens on the surface of diseased cells. The transporter associated with antigen processing (TAP) transports nearly the entire repertoire of antigenic peptides into the endoplasmic reticulum for MHC - I loading. How TAP transports peptides specific for MHC - I is unclear. In this study, we used cryo - EM to determine a series of structures of human TAP, both in the absence...
• A modified viscous flow law for natural glacier ice: Scaling from laboratories to ice sheets AI翻译
  作者：Ranganathan, Meghana; Minchew, Brent
  作者单位：Massachusetts Institute of Technology (MIT); University System of Georgia; Georgia Institute of Technology
  摘要：Glacier flow modulates sea level and is governed largely by the viscous deformation ice. Multiple molecular -scale mechanisms facilitate viscous deformation, but it remains unclear how each contributes to glacier -scale deformation. Here, we present a model ice deformation that bridges laboratory and glacier scales, unifies existing estimates the viscous parameters, and provides a framework for estimating the parameters from observations and incorporating flow laws derived from laboratory obse...
• Understanding the Asian water tower requires a redesigned precipitation observation strategy AI翻译
  作者：Miao, Chiyuan; Immerzeel, Walter W.; Xu, Baiqing; Yang, Kun; Duan, Qingyun; Li, Xin
  作者单位：Beijing Normal University; Utrecht University; Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Tsinghua University; Hohai University
  摘要：The Asian water tower (AWT) serves as the source of 10 major Asian river systems and supports the lives of - 2 billion people. Obtaining reliable precipitation data over the AWT is a prerequisite for understanding the water cycle within this pivotal region. Here, we quantitatively reveal that the observed precipitation over the AWT is considerably underestimated in view of observational evidence from three water cycle components, namely, evapotranspiration, runoff, and accumulated snow. We fou...
• Neuronal differentiation requires BRAT1 complex to remove REST from chromatin AI翻译
  作者：Dokaneheifard, Sadat; Santos, Helena Gomes Dos; Valencia, Monica Guiselle; Arigela, Harikumar; Edupuganti, Raghu Ram; Shiekhattar, Ramin
  作者单位：University of Miami
  摘要：Repressor element - 1 silencing transcription factor (REST) is required for the formation of mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST - mediated silencing of key neurogenesis genes are not known. Here, we show that BRCA1 Associated ATM Activator 1 (BRAT1), a gene linked to neurodegenerative diseases, is required for the activation of REST - responsive genes du...
• Phase- dependent word perception emerges from region- specific sensitivity to the statistics of language AI翻译
  作者：Ten Oever, Sanne; Titone, Lorenzo; te Rietmolen, Noemie; Martin, Andrea E.
  作者单位：Max Planck Society; Radboud University Nijmegen; Maastricht University; Max Planck Society
  摘要：Neural oscillations reflect fluctuations in excitability, which biases the percept of ambiguous sensory input. Why this bias occurs is still not fully understood. We hypothesized that neural populations representing likely events are more sensitive, and thereby become active on earlier oscillatory phases, when the ensemble itself is less excitable. Perception of ambiguous input presented during less - excitable phases should therefore be biased toward frequent or predictable stimuli that have ...