A high- light therapy restores the circadian clock and corrects the pathological syndrome generated in restricted-fed mice

• 成果类型: Article
• 署名作者: Damara, Manohar; Misra, Nisha; Chambon, Pierre
• 署名单位: Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14410
• DOI: 10.1073/pnas.2403770121
• 发表日期: 2024-08-06
• 关键词: suprachiasmatic nucleus; blood-pressure; rhythms; per1; metabolism; shift; disruption; sleep; leads; rats

摘要

Time- restricted feeding (RF) is known to shift the phasing of gene expression in most primary metabolic tissues, whereas a time misalignment between the suprachiasmatic nucleus circadian clock (SCNCC) and its peripheral CCs (PCC's) is known to induce various pathophysiological conditions, including a metabolic syndrome. We now report that a unique light therapy, involving different light intensities (T ZT0- ZT12150-TZT0- ZT12 700lx, T ZT0- ZT1275-TZT0- ZT12150 lx, and T ZT0- ZT12350-TZT0- ZT12700 lx), realigns the RF- generated misalignment between the SCNCC and the PCC's. Using such high- light regime, we show that through shifting the SCNCC and its activity, it is possible in a RF and night- shifted mouse model to prevent/correct pathophysiologies (e.g., a metabolic syndrome, a loss of memory, cardiovascular abnormalities). Our data indicate that such a high- light regime could be used as a unique chronotherapy, for those working on night shifts or suffering from jet- lag, in order to realign their SCNCC and PCC's, thereby preventing the generation of pathophysiological conditions.