37期

最新文章

• Generalized Einstein relations between absorption and emission spectra at thermodynamic equilibrium AI翻译
  作者：Ryu, Jisu; Yeola, Sarang; Jonas, David M.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：We present Einstein coefficient spectra and a detailed-balance derivation of generalized Einstein relations between them that is based on the connection between spontaneous and stimulated emission. If two broadened levels or bands overlap in energy, transitions between them need not be purely absorptive or emissive. Consequently, spontaneous emission can occur in both transition directions, and four Einstein coefficient spectra replace the three Einstein coefficients for a line. At equilibrium...
• ER- associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA- PKcs AI翻译
  作者：Xiang, Zhiyuan; Hou, Guixue; Zheng, Shanliang; Lu, Minqiao; Li, Tianyu; Lin, Qingyu; Liu, Hao; Wang, Xingwen; Guan, Tianqi; Wei, Yuhan; Zhang, Wenxin; Zhang, Yi; Liu, Chaoran; Li, Li; Lei, Qun-ying; Hu, Ying
  作者单位：Harbin Institute of Technology; Harbin Institute of Technology; Beijing Genomics Institute (BGI); Harbin Medical University; Fudan University; Fudan University
  摘要：Proteostasis and genomic integrity are respectively regulated by the endoplasmic reticulum-associated protein degradation (ERAD) and DNA damage repair signaling pathways, with both pathways essential for carcinogenesis and drug resistance. How these signaling pathways coordinate with each other remains unexplored. We found that ER stress specifically induces the DNA-PKcs-regulated nonhomologous end joining (NHEJ) pathway to amend DNA damage and impede cell death. Intriguingly, sustained ER str...
• Long- lasting organics removal via •OH adsorbed transition metal flocs: Electron transfer- mediated H- bond and van der Waals force AI翻译
  作者：Zhao, Manshu; Wang, Xinhua; Wang, Shuguang; Lu, Wenhui; He, Maoxia; Gao, Mingming
  作者单位：Shandong University; Shandong University; Shandong University; Qilu University of Technology; Shandong University
  摘要：Homogenous advanced oxidation processes (AOPs) based on transition metal catalysts toward the activation of H2O2 to hydroxyl radical (center dot OH) have been widely applied to organic pollutants removal, such as Fenton and Fenton- like processes. These transition metal catalysts mostly flocculate as the pH increases. It's worth noting that the formed transition metal flocs are complex heterogeneous aggregations with active substances, providing diverse reaction spaces and interfaces. However,...
• Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss AI翻译
  作者：Akiba, Ryutaro; Boniec, Shane Lind; Knecht, Sharm; Uyama, Hirofumi; Tu, Hung- Ya; Baba, Takayuki; Takahashi, Masayo; Mandai, Michiko; Wong, Rachel O.
  作者单位：University of Washington; University of Washington Seattle; RIKEN; Chiba University; University of Osaka
  摘要：The retinal fovea in human and nonhuman primates is essential for high acuity and color vision. Within the fovea lies specialized circuitry in which signals from a single cone photoreceptor are largely conveyed to one ON and one OFF type midget bipolar cell (MBC), which in turn connect to a single ON or OFF midget ganglion cell (MGC), respectively. Restoring foveal vision requires not only photoreceptor replacement but also appropriate reconnection with surviving ON and OFF MBCs and MGCs. Howe...
• The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease AI翻译
  作者：Jensen, Anne Mette G.; Raska, Jan; Fojtik, Petr; Monti, Giulia; Lunding, Melanie; Bartova, Simona; Pospisilova, Veronika; van der Lee, Sven J.; Van Dongen, Jasper; Bossaerts, Liene; Van Broeckhoven, Christine; Dols-Icardo, Oriol; Lleo, Alberto; Bellini, Sonia; Ghidoni, Roberta; Hulsman, Marc; Petsko, Gregory A.; Sleegers, Kristel; Bohaciakova, Dasa; Holstege, Henne; Andersen, Olav M.
  作者单位：Aarhus University; Masaryk University; St. Anne's University Hospital Brno (FNUSA); St. Anne's University Hospital Brno (FNUSA-ICRC); Vrije Universiteit Amsterdam; Flanders Institute for Biotechnology (VIB); University of Antwerp; Flanders Institute for Biotechnology (VIB); Autonomous University of Barcelona; CIBERNED; Autonomous University of Barcelona; IRCCS Fatebenefratelli; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
  摘要：Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA, have been accepted as causal of Alzheimer's disease (AD). However, most genetic variants observed in SORL1 are missense variants, for which it is complicated to determine the pathogenicity level because carriers come from pedigrees too small to be informative for penetrance estimations. Here, we describe three unrelated families in which the SORL1 coding missense variant rs772677709, that leads to a p.Y1816C ...
• Charting the future of high forest low deforestation jurisdictions AI翻译
  作者：Teo, Hoong Chen; Sarira, Tasya Vadya; Tan, Audrey R. P.; Cheng, Yanyan; Koh, Lian Pin
  作者单位：National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore
  摘要：High forest low deforestation jurisdictions (HFLDs) contain many of the world's last intact forests with historically low deforestation. Since carbon financing typically uses historical deforestation rates as baselines, HFLDs facing the prospect of future threats may receive insufficient incentives to be protected. We found that from 2002 to 2020, HFLDs (n = 310) experienced 44% higher deforestation rates than their historical baselines, and 60 HFLDs underwent periods of high deforestation (de...
• Structural basis for surface activation of the classical complement cascade by the short pentraxin C- reactive protein AI翻译
  作者：Noone, Dylan P.; Isendoorn, Marjolein M. E.; Hamers, Sebastiaan M. W. R.; Keizer, Mariska E.; Wulffele, Jip; van der Velden, Tijn T.; Dijkstra, Douwe J.; Trouw, Leendert A.; Filippov, Dmitri V.; Sharp, Thomas H.
  作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Bristol
  摘要：Human C- reactive protein (CRP) is a pentameric complex involved in immune defense and regulation of autoimmunity. CRP is also a therapeutic target, with both administration and depletion of serum CRP being pursued as a possible treatment for autoimmune and cardiovascular diseases, among others. CRP binds to phosphocholine (PC) moieties on membranes to activate the complement system via the C1 complex, but it is unknown how CRP, or any pentraxin, binds to C1. Here, we present a cryoelectron to...
• pSTAT3 activation of Foxl2 initiates the female pathway underlying temperature- dependent sex determination AI翻译
  作者：Wu, Pengfei; Wang, Xifeng; Ge, Chutian; Jin, Lin; Ding, Zihan; Liu, Fang; Zhang, Ju; Gao, Fei; Du, Weiguo
  作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang Wanli University; Zhejiang Wanli University; Chinese Academy of Sciences; Institute of Zoology, CAS
  摘要：Ovarian development was traditionally recognized as a default sexual outcome and therefore received much less scientific attention than testis development. In turtles with temperature- dependent sex determination (TSD), how the female pathway is initiated to induce ovary development remains unknown. In this study, we have found that phosphorylation of the signal transducer and activator of transcription 3 (pSTAT3) and Foxl2 exhibit temperature- dependent sexually dimorphic patterns and tempo- ...
• Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance AI翻译
  作者：Zhang, Nan; Zhang, Rui; Jiang, Lei; Gao, Zhaoyu; Xia, Wenzhen; Ma, Xiaoying; Qin, Yushi; Zhang, Di; Li, Jiazheng; Tian, Pei; Zhang, Qi; Wang, Wanchang; Zhang, Kaixia; Xu, Shan; Zhao, Na; Xu, Shunjiang
  作者单位：Hebei Medical University; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：Epidemiological studies have revealed an inverse relationship between the incidence We aimed to determine whether the incidence of CRC is reduced in AD- like mice and whether gut microbiota confers resistance to tumorigenesis through inducing inflammatory tolerance using 16S ribosomal RNA gene sequencing and fecal microbiota transplantation (FMT). AD- like mice experienced a significantly decreased incidence of CRC tumorigenesis induced by azoxymethane-dextran sodium sulfate as evidenced by su...
• Joint trajectory inference for single-cell genomics using deep learning with a mixture prior AI翻译
  作者：Du, Jin-Hong; Chen, Tianyu; Gao, Ming; Wang, Jingshu
  作者单位：Carnegie Mellon University; Carnegie Mellon University; University of Texas System; University of Texas Austin; University of Chicago; University of Chicago
  摘要：Trajectory inference methods are essential for analyzing the developmental paths of cells in single-cell sequencing datasets. It provides insights into cellular differentiation, transitions, and lineage hierarchies, helping unravel the dynamic processes underlying development and disease progression. However, many existing tools lack a coherent statistical model and reliable uncertainty quantification, limiting their utility and robustness. In this paper, we introduce VITAE (Variational Infere...