37期

最新文章

• Inherited human RelB deficiency impairs innate and adaptive immunity to infection AI翻译
  作者：Le Voyer, Tom; Renkilaraj, Majistor Raj Luxman Maglorius; Moriya, Kunihiko; Lorenzo, Malena Perez; Nguyen, Tina; Gao, Liwei; Rubin, Tamar; Cederholm, Axel; Ogishi, Masato; Franco, Carlos A. Arango-; Beziat, Vivien; Levy, Romain; Migaud, Melanie; Rapaport, Franck; Itan, Yuval; Deenick, Elissa K.; Cortese, Irene; Lisco, Andrea; Boztug, Kaan; Abel, Laurent; Boisson-Dupuis, Stephanie; Boisson, Bertrand; Frosk, Patrick; Ma, Cindy S.; Landegren, Nils; Celmeli, Fatih; Casanova, Jean- Laurent; Tangye, Stuart G.; Puel, Anne
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Garvan Institute of Medical Research; University of New South Wales Sydney; University of Manitoba; Uppsala University; Rockefeller University; Universidad de Antioquia; Icahn School of Medicine at Mount Sinai; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Saint Anna Children's Hospital; St. Anna Children's Cancer Research Institute (CCRI); Medical University of Vienna; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; University of Manitoba; Antalya Training & Research Hospital; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Howard Hughes Medical Institute
  摘要：We report two unrelated adults with homozygous (P1) or compound heterozygous (P2) private loss- of- function variants of V-Rel Reticuloendotheliosis Viral Oncogene Homolog B ( RELB ) . The resulting deficiency of functional RelB impairs the induction of NFKB2 mRNA and NF-kappa B2 (p100/p52) protein by lymphotoxin in the fibroblasts of the patients. These defects are rescued by transduction with wild- type RELB complementary DNA (cDNA). By contrast, the response of RelB- deficient fibroblasts t...
• Evolution fails to rescue a population in an increasingly variable environment AI翻译
  作者：Olazcuaga, Laure; Hufbauer, Ruth A.
  作者单位：Centre National de la Recherche Scientifique (CNRS); Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
• Efficient asymmetric diffusion channel in MnCo2O4 spinel for ammonium- ion batteries AI翻译
  作者：Xiao, Kang; Xiao, Bo-Hao; Li, Jian-Xi; Cao, Shunsheng; Liu, Zhao-Qing
  作者单位：Guangzhou University; Guangzhou University; Guangzhou University; Jiangsu University
  摘要：Transition metal oxides ion diffusion channels have been developed for ammonium- ion batteries (AIBs). However, the influence of microstructural features of diffusion channels on the storage and diffusion behavior of NH4+is not fully unveiled. In this study, by using MnCo2O4 spinel as a model electrode, the asymmetric ion diffusion channels of MnCo2O4 have been regulated through bond length optimization strategy and investigate the effect of channel size on the diffusion process of NH4+. In ad...
• Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis AI翻译
  作者：Lopes, Filipa L.; Jordan, Pau Formosa; Malivert, Alice; Margalha, Leonor; Confraria, Ana; Feil, Regina; Lunn, John E.; Jonsson, Henrik; Landrein, Benoit; Baena-Gonzalez, Elena
  作者单位：Instituto Gulbenkian de Ciencia; Universidade Nova de Lisboa; University of Cambridge; University of Oxford; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; INRAE; Max Planck Society; University of Cambridge; Lund University
  摘要：In plants, development of all above- ground tissues relies on the shoot apical meristem (SAM) which balances cell proliferation and differentiation to allow life- long growth. To maximize fitness and survival, meristem activity is adjusted to the prevailing conditions through a poorly understood integration of developmental signals with environmental and nutritional information. Here, we show that sugar signals influence SAM function by altering the protein levels of SHOOT MERISTEMLESS (STM), ...
• High- resolution stereolithography: Negative spaces enabled by control of fluid mechanics AI翻译
  作者：Coates, Ian A.; Pan, William; Saccone, Max A.; Lipkowitz, Gabriel; Ilyin, Dan; Driskill, Madison M.; Dulay, Maria T.; Frank, Curtis W.; Shaqfeh, Eric S. G.; Desimone, Joseph M.
  作者单位：Stanford University; Stanford University; Stanford University
  摘要：Stereolithography enables the fabrication of three- dimensional (3D) freeform structures via light- induced polymerization. However, the accumulation of ultraviolet dose within resin trapped in negative spaces, such as microfluidic channels or voids, can result in the unintended closing, referred to as overcuring, of these negative spaces. We report the use of injection continuous liquid interface production to continuously displace resin at risk of overcuring in negative spaces created in pre...
• QnAs with Laura E. Wallace AI翻译
  作者：Hardcastle, Matthew
• Microevolutionary change in wild stickleback: Using integrative time- series data to infer responses to selection AI翻译
  作者：Strickland, Kasha; Matthews, Blake; Phillips, Joseph S.; Jonsson, Zophonias O.; Einarsson, Arni; Kristjansson, Bjarni K.; Rasanen, Katja
  作者单位：University of Edinburgh; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Iceland; Creighton University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Jyvaskyla
  摘要：A central goal in evolutionary biology is to understand how different evolutionary processes cause trait change in wild populations. However, quantifying evolutionary change in the wild requires linking trait change to shifts in allele frequencies at causal loci. Nevertheless, datasets that allow for such tests are extremely rare and existing theoretical approaches poorly account for the evolutionary dynamics that likely occur in ecological settings. Using a decade- long integrative phenome-to...
• Reversed I1Cu4 single- atom sites for superior neutral ammonia electrosynthesis with nitrate AI翻译
  作者：Zhou, Bing; Tong, Yawen; Yao, Yancai; Zhang, Weixing; Zhan, Guangming; Zheng, Qian; Hou, Wei; Gu, Xiang - Kui; Zhang, Lizhi
  作者单位：Central China Normal University; Shanghai Jiao Tong University; Wuhan University
  摘要：Electrochemical ammonia (NH3) synthesis from nitrate reduction (NITRR) offers an appealing solution for addressing environmental concerns and the energy crisis. However, most of the developed electrocatalysts reduce NO3- to NH3 via a hydrogen (H*)- mediated reduction mechanism, which suffers from undesired H*- H* dimerization to H2, resulting in unsatisfactory NH3 yields. Herein, we demonstrate that reversed I1Cu4 single- atom sites, prepared by anchoring iodine single atoms on the Cu surface,...
• Fluorescence- activated droplet sequencing (FAD- seq) directly provides sequences of screening hits in antibody discovery AI翻译
  作者：Autour, Alexis; Merten, Christoph A.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; European Molecular Biology Laboratory (EMBL)
  摘要：Droplet microfluidics has become a very powerful tool in high- throughput screening, including antibody discovery.Screens are usually carried out by physically sorting droplets hosting cells of the desired phenotype, breaking them, recovering the encapsulated cells, and sequencing the paired antibody light and heavy chain genes at the single- cell level. This series of multiple consecutive manipulation steps of rare screening hits is complex and challenging, resulting in a significant loss of ...
• Achieving metal- like catalysis from semiconductors for on- surface synthesis AI翻译
  作者：E., Wenlong; Yi, Wei; Ding, Honghe; Zhu, Junfa; Rosei, Federico; Yang, Xueming; Yu, Miao
  作者单位：Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Harbin Institute of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of Trieste; Southern University of Science & Technology; University of Electronic Science & Technology of China
  摘要：Free of posttransfer, on- surface synthesis (OSS) of single- atomic- layer nanostructures directly on semiconductors holds considerable potential for next- generation devices. However, due to the high diffusion barrier and abundant defects on semiconductor surfaces, extended and well- defined OSS on semiconductors has major difficulty. Furthermore, given semiconductors' limited thermal catalytic activity, initiating high- barrier reactions remains a significant challenge. Herein, using TiO2(01...