37期

最新文章

• Mechanical force matters in early T cell activation AI翻译
  作者：Fritzsche, Marco; Kruse, Karsten
  作者单位：University of Oxford; Kennedy Institute for Rheumatology; Rosalind Franklin Institute; University of Geneva; University of Geneva
  摘要：Mechanical force has repeatedly been highlighted to be involved in T cell activation. However, the biological significance of mechanical force for T cell receptor signaling remains under active consideration. Here, guided by theoretical analysis, we provide a perspective on how mechanical forces between a T cell and an antigen-presenting cell can influence the bond of a single T cell receptor major histocompatibility complex during early T cell activation. We point out that the lifetime of T c...
• Presaccadic preview shapes postsaccadic processing more where perception is poor AI翻译
  作者：Liu, Xiaoyi; Melcher, David; Carrasco, Marisa; Hanning, Nina M.
  作者单位：New York University; New York University Abu Dhabi; Princeton University; New York University; New York University Abu Dhabi; New York University; Humboldt University of Berlin
  摘要：The presaccadic preview of a peripheral target enhances the efficiency of its postsaccadic processing, termed the extrafoveal preview effect. Peripheral visual performance-and thus the quality of the preview-varies around the visual field, even at isoeccentric locations: It is better along the horizontal than vertical meridian and along the lower than upper vertical meridian. To investigate whether these polar angle asymmetries influence the preview effect, we asked human participants to previ...
• Social evolution and reproductive castes in trematode parasites AI翻译
  作者：Richards, Miriam H.
  作者单位：Brock University
• Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration AI翻译
  作者：Fu, Chaoyu; Dilasser, Florian; Lin, Shao-Zhen; Karnat, Marc; Arora, Aditya; Rajendiran, Harini; Ong, Hui Ting; Brenda, Nai Mui Hoon; Phow, Sound Wai; Hirashima, Tsuyoshi; Sheetz, Michael; Rupprecht, Jean-Francois; Tlili, Sham; Viasnoff, Virgile
  作者单位：National University of Singapore; Aix-Marseille Universite; Universite de Toulon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); National University of Singapore; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
  摘要：Collective cell migration is crucial in various physiological processes, including wound healing, morphogenesis, and cancer metastasis. Adherens Junctions (AJs) play a pivotal role in regulating cell cohesion and migration dynamics during tissue remodeling. While the role and origin of the junctional mechanical tension at AJs have been extensively studied, the influence of the actin cortex structure and dynamics on junction plasticity remains incompletely understood. Moreover, the mechanisms u...
• Interoceptive signals shape the earliest markers and neural pathway to awareness at the visual threshold AI翻译
  作者：Leupin, Viviana; Britz, Juliane
  作者单位：University of Fribourg
  摘要：respiratory cycle can modulate cortical excitability and so affect awareness. It remains debated at what stages of processing they affect awareness- related event- related potentials (ERPs) in different sensory modalities. We investigated the influence of the cardiac (systole/diastole) and the respiratory (inhalation/exhalation) phase on awareness- related ERPs. Subjects discriminated visual threshold stimuli while their electroencephalogram, electrocardiogram, and respiration were simultaneou...
• Structure- based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion- like conformation AI翻译
  作者：Sponholtz, Madeline R.; Byrne, Patrick O.; Lee, Alison G.; Ramamohan, Ajit R.; Goldsmith, Jory A.; McCool, Ryan S.; Zhou, Ling; Johnson, Nicole V.; Hsieh, Ching- Lin; Connors, Megan; Karthigeyan, Krithika P.; Crooks, Chelsea M.; Fuller, Adelaide S.; Campbell, John D.; Permar, Sallie R.; Maynard, Jennifer A.; Yu, Dong; Bottomley, Matthew J.; McLellan, Jason S.
  作者单位：University of Texas System; University of Texas Austin; Cornell University; Weill Cornell Medicine; Dynavax Technologies; University of Texas System; University of Texas Austin; GlaxoSmithKline
  摘要：Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein required for viral entry. HCMV vaccine candidates containing gB have demonstrated moderate clinical efficacy, but no HCMV vaccine has been approved. Here, we used structure- based design to identify and characterize amino acid substitutions that stabilize gB in its metastable prefusion conformation. One variant containing two engineered interprotomer disulfide bonds and two cavity- filling substitutions (gB...