37期

最新文章

• Reply to Jautzy et al.: Considerations on methane equilibrium-do not forget to add the pepper AI翻译
  作者：Chowdhury, Anirban; Ventura, Gregory T.; Owino, Yaisa; Lalk, Ellen J.; MacAdam, Natasha; Dooma, John M.; Ono, Shuhei; Fowler, Martin; MacDonald, Adam; MacRae, R. Andrew; Hubert, Casey R. J.; Bentley, Jeremy N.; Kerr, Mitchell J.
  作者单位：Saint Marys University - Canada; Massachusetts Institute of Technology (MIT); University of Calgary
• Deep learning models map rapid plant species changes from citizen science and remote sensing data AI翻译
  作者：Gillespie, Lauren E.; Ruffley, Megan; Alonso, Moises Exposito -
  作者单位：Carnegie Institution for Science; Stanford University; University of California System; University of California Berkeley; Stanford University; Carnegie Institution for Science; Howard Hughes Medical Institute; University of California System; University of California Berkeley
  摘要：Anthropogenic habitat destruction and climate change are reshaping the geographic distribution of plants worldwide. However, we are still unable to map species shifts at high spatial, temporal, and taxonomic resolution. Here, we develop a deep learning model trained using remote sensing images from California paired with half a million citizen science observations that can map the distribution of over 2,000 plant species. Our model-Deepbiosphere-not only outperforms many common species distrib...
• Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2 AI翻译
  作者：Hattori, Shin-ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki
  作者单位：Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Tohoku University; Kumamoto University; Japan Synchrotron Radiation Research Institute; University of Tokyo; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; University of Tokyo; Tohoku University; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Wisconsin System; University of Wisconsin Madison; Kumamoto University
  摘要：We generated SARS-CoV-2 variants resistant to three SARS-CoV-2 main protease (Mpro) inhibitors (nirmatrelvir, TKB245, and 5h), by propagating the ancestral SARS- CoV- 2 WK521 WT in VeroE6 TMPRSS2 cells with increasing concentrations of each inhibitor and examined their structural and virologic profiles. A predominant E166V-carrying variant (SARS- CoV- 2 WK521E166V ), which emerged when passaged with nirmatrelvir and TKB245, proved to be resistant to the two inhibitors. A recombinant SARS- CoV-...
• Plasma cell- free RNA signatures of inflammatory syndromes in children AI翻译
  作者：Loy, Conor J.; Servellita, Venice; Sotomayor-Gonzalez, Alicia; Bliss, Andrew; Lenz, Joan S.; Belcher, Emma; Suslovic, Will; Nguyen, Jenny; Williams, Meagan E.; Oseguera, Miriam; Gardiner, Michael A.; Choi, Jong-Ha; Hsiao, Hui-Mien; Wang, Hao; Kim, Jihoon; Shimizu, Chisato; Tremoulet, Adriana H.; Delaney, Meghan; DeBiasi, Roberta L.; Rostad, Christina A.; Burns, Jane C.; Chiu, Charles Y.; De Vlaminck, Iwijn
  作者单位：Cornell University; University of California System; University of California San Francisco; Children's National Health System; Rady Childrens Hospital San Diego; University of California System; University of California San Diego; Emory University; Children's Healthcare of Atlanta (CHOA); Yale University; George Washington University; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI)
  摘要：Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell- free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, i...
• Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity AI翻译
  作者：Martinez, Matias; Cai, Tianying; Yang, Beiming; Zhou, Zexi; Shankman, Stewart A.; Mittal, Vijay A.; Haase, Claudia M.; Qu, Yang
  作者单位：Northwestern University; Northwestern University; Northwestern University; University of Minnesota System; University of Minnesota Twin Cities; University of Texas System; University of Texas Austin; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：The transition to adolescence is a critical period for mental health development. Socio- experiential environments play an important role in the emergence of depressive symptoms with some adolescents showing more sensitivity to social contexts than others. Drawing on recent developmental neuroscience advances, we examined whether hippocampal volume amplifies social context effects in the transition to adolescence. We analyzed 2- y longitudinal data from the Adolescent Brain Cognitive Developme...
• Performance enhancement and mechanism of electroenhanced peroxymonosulfate activation by single- atom Fe catalyst modified electrodes AI翻译
  作者：Li, Shuaishuai; Wang, Wei; Wu, Huizhong; Zhang, Xiuwu; Liang, Ruiheng; Zhang, Xuyang; Song, Ge; Jing, Jiana; Li, Shasha; Zhou, Minghua
  作者单位：Nankai University
  摘要：Peroxymonosulfate-based electrochemical advanced oxidation processes (PMS- EAOPs) have great potential for sustainable water purification, so an in- depth understanding of its catalytic mechanism is imperative to facilitate its practical application. Herein, the performance enhancement and mechanism of electroenhanced PMS activation by single- atom Fe catalyst modified carbon felt was investigated. Compared with the anode, the cathode exhibited faster bisphenol A degradation ( k cathode = 0.07...
• Diapiric controls on deep- biosphere oases: Take with a grain of salt AI翻译
  作者：Jautzy, Josue J.; Campbell, Calvin; Desiage, Pierre- Arnaud; Douglas, Peter M. J.; Fosu, Benjamin R.; Larmagnat, Stephanie; Savard, Martine M.
  作者单位：Natural Resources Canada; Lands & Minerals Sector - Natural Resources Canada; Geological Survey of Canada; Natural Resources Canada; Lands & Minerals Sector - Natural Resources Canada; Geological Survey of Canada; McGill University
• ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation AI翻译
  作者：Sato, Kaoru; Takayama, Ken - ichi; Saito, Yuko; Inoue, Satoshi
  摘要：Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by cognitive decline and learning/memory impairment associated with neuronal cell loss. Estrogen- related receptor alpha (ERR alpha) and ERR gamma, which are highly expressed in the brain, have emerged as potential AD regulators, with unelucidated underlying mechanisms. Here, we identified genome-wide binding sites for ERR alpha and ERR gamma in human neuronal cells. They commonly target a subset of genes associate...
• Time- resolved NMR detection of prolyl- hydroxylation in intrinsically disordered region of HIF-1α AI翻译
  作者：He, Wenguang; Seabrook, Genevieve M. C. Gasmi; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
  作者单位：University of Toronto; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University of Toronto
  摘要：Prolyl- hydroxylation is an oxygen- dependent posttranslational modification (PTM) that is known to regulate fibril formation of collagenous proteins and modulate cellular expression of hypoxia- inducible factor (HIF) alpha subunits. However, our understanding of this important but relatively rare PTM has remained incomplete due to the lack of biophysical methodologies that can directly measure multiple prolyl- hydroxylation events within intrinsically disordered proteins. Here, we describe a ...
• Superresolution imaging of antibiotic- induced structural disruption of bacteria enabled by photochromic glycomicelles AI翻译
  作者：Hu, Xi-Le; Gan, Hui-Qi; Gui, Wen-Zhen; Yan, Kai-Cheng; Sessler, Jonathan L.; Yi, Dong; Tian, He; He, Xiao-Peng
  作者单位：East China University of Science & Technology; East China University of Science & Technology; Naval Medical University; University of Bath; University of Texas System; University of Texas Austin
  摘要：Bacterial evolution, particularly in hospital settings, is leading to an increase in multidrug resistance. Understanding the basis for this resistance is critical as it can drive discovery of new antibiotics while allowing the clinical use of known antibiotics to be optimized. Here, we report a photoactive chemical probe for superresolution microscopy that allows for the in situ probing of antibiotic- induced structural disruption of bacteria. Conjugation between a spiropyran (SP) and galactos...