Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance

• 成果类型: Article
• 署名作者: Zhang, Nan; Zhang, Rui; Jiang, Lei; Gao, Zhaoyu; Xia, Wenzhen; Ma, Xiaoying; Qin, Yushi; Zhang, Di; Li, Jiazheng; Tian, Pei; Zhang, Qi; Wang, Wanchang; Zhang, Kaixia; Xu, Shan; Zhao, Na; Xu, Shunjiang
• 署名单位: Hebei Medical University; Chinese Academy of Medical Sciences - Peking Union Medical College
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14641
• DOI: 10.1073/pnas.2314337121
• 发表日期: 2024-09-10
• 关键词: lipopolysaccharide; permeability; association; complex

摘要

Epidemiological studies have revealed an inverse relationship between the incidence We aimed to determine whether the incidence of CRC is reduced in AD- like mice and whether gut microbiota confers resistance to tumorigenesis through inducing inflammatory tolerance using 16S ribosomal RNA gene sequencing and fecal microbiota transplantation (FMT). AD- like mice experienced a significantly decreased incidence of CRC tumorigenesis induced by azoxymethane-dextran sodium sulfate as evidenced by suppressed intestinal inflammation compared with control mice. However, FMT from age- matched control mice reversed the inhibitory effects on the tumorigenesis of CRC and inflammatory response in AD- like mice. The key bacterial genera in gut microbiota, including Prevotella, were increased in both the AD- like mice and in patients with amnestic mild cognitive impairment (aMCI) but were decreased in patients with mice. Imbalanced gut microbiota increased intestinal barrier permeability, which facil