37期

最新文章

• Phenoxyacetic acid enhances nodulation symbiosis during the rapid growth stage of soybean AI翻译
  作者：Li, Weijun; Zhu, Xinfang; Zhang, Mengyue; Yan, Xifeng; Leng, Junchen; Zhou, Yuhong; Liu, Like; Zhang, Dajian; Yuan, Xianzheng; Xue, Dawei; Tian, Huiyu; Ding, Zhaojun
  作者单位：Shandong University; Liaocheng University; Shandong Agricultural University; Shandong University; Hangzhou Normal University; Shandong University
  摘要：Root exudates are known signaling agents that influence legume root nodulation, but the molecular mechanisms for nonflavonoid molecules remain largely unexplored. The number of soybean root nodules during the initial growth phase shows substantial discrepancies at distinct developmental junctures. Using a combination of metabolomics analyses on root exudates and nodulation experiments, we identify a pivotal role for certain root exudates during the rapid growth phase in promoting nodulation. P...
• Biosynthesis of resolvin D1, resolvin D2, and RCTR1 from 7,8(S,S)- epoxytetraene in human neutrophils and macrophages AI翻译
  作者：Nshimiyimana, Robert; Simard, Melissa; Teder, Tarvi; Rodriguez, Ana R.; Spur, Bernd W.; Haeggstroem, Jesper Z.; Serhan, Charles N.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Karolinska Institutet; Rowan University
  摘要：While the acute inflammatory response to harmful stimuli is protective, unrestrained neutrophil swarming drives collateral tissue damage and inflammation. Biosynthesized from omega- 3 essential polyunsaturated fatty acids, resolvins are a family of signaling molecules produced by immune cells within the resolution phase to orchestrate return to homeostasis. Understanding the mechanisms that govern biosynthesis of these potent molecules gives insight into stimulating endogenous resolution and o...
• The Mitotic Checkpoint Complex controls the association of Cdc20 regulatory protein with the ubiquitin ligase APC/C in mitosis AI翻译
  作者：Sitry-Shevah, Danielle; Miniowitz-Shemtov, Shirly; Dan, Tanya Liburkin; Hershko, Avram
  作者单位：Technion Israel Institute of Technology; Rappaport Faculty of Medicine
  摘要：The ubiquitin ligase Anaphase- Promoting Complex/Cyclosome (APC/C) and its regulatory protein Cdc20 play important roles in the control of different stages of mitosis. APC/C associated with Cdc20 is active and promotes metaphase-anaphase transition by targeting for degradation inhibitors of anaphase initiation. Earlier in mitosis, premature action of APC/C is prevented by the mitotic checkpoint (or spindle assembly checkpoint) system, which ensures that anaphase is not initiated until all chro...
• Single-cell analysis via manifold fitting: A framework for RNA clustering and beyond AI翻译
  作者：Yao, Zhigang; Li, Bingjie; Lu, Yukun; Yau, Shing-Tung
  作者单位：National University of Singapore; Tsinghua University
  摘要：Single-cell RNA sequencing (scRNA-seq) data, susceptible to noise arising from biological variability and technical errors, can distort gene expression analysis and impact cell similarity assessments, particularly in heterogeneous populations. Current methods, including deep learning approaches, often struggle to accurately characterize cell relationships due to this inherent noise. To address these challenges, we introduce scAMF (Single-cell Analysis via Manifold Fitting), a framework designe...
• Gene length could be a critical factor in the aging of the genome AI翻译
  作者：Brouillette, Monique
• Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction AI翻译
  作者：Le, Shimin; Yu, Miao; Fu, Chaoyu; Heier, Jonathon A.; Martin, Sterling; Hardin, Jeff; Yan, Jie
  作者单位：National University of Singapore; Xiamen University; Zhejiang University; Zhejiang University; National University of Singapore; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; National University of Singapore; TJU-NUS Joint Institute
  摘要：The Caenorhabditis elegans HMP-2/HMP-1 complex, akin to the mammalian /3-catenin- a-catenin complex, serves as a critical mechanosensor at cell-cell adherens junctions, transducing tension between HMR-1 (also known as cadherin in mammals) and the actin cytoskeleton. Essential for embryonic development and tissue integrity in C. elegans, this complex experiences tension from both internal actomyosin contractility and external mechanical microenvironmental perturbations. While offering a valuabl...
• Relative genotoxicity of polycyclic aromatic hydrocarbons inferred from free energy perturbation approaches AI翻译
  作者：Urwin, Derek J.; Tran, Elise; Alexandrova, Anastassia N.
  作者单位：University of California System; University of California Los Angeles
  摘要：Utilizing molecular dynamics and free energy perturbation, we examine the relative binding affinity of several covalent polycyclic aromatic hydrocarbon- DNA (PAHDNA) adducts at the central adenine of NRAS codon-61, a mutational hotspot implicated in cancer risk. Several PAHs classified by the International Agency for Research on Cancer as probable, possible, or unclassifiable as to carcinogenicity are found to have greater binding affinity than the known carcinogen, benzo[a]pyrene (B[a]P). van...
• Breaking the activity-selectivity trade- off of CO2 hydrogenation to light olefins AI翻译
  作者：Wang, Xiaoyue; Zeng, Ting; Guo, Xiaohong; Yan, Zhiqiang; Ban, Hongyan; Yao, Ruwei; Li, Congming; Gu, Xiang-Kui; Ding, Mingyue
  作者单位：Taiyuan University of Technology; Wuhan University; Wuhan University
  摘要：Catalytic hydrogenation of CO2 to value- added fuels and chemicals is of great importance to carbon neutrality but suffers from an activity-selectivity trade- off, leading to limited catalytic performance. Herein, the ZnFeAlO4 + SAPO-34 composite catalyst was designed, which can simultaneously achieve a CO2 conversion of 42%, a CO selectivity of 50%, and a C2-C4= selectivity of 83%, resulting in a C2-C4= yield of almost 18%. This superior catalytic performance was found to be from the presence...
• High- level succinic acid production by overexpressing a magnesium transporter in Mannheimia succiniciproducens AI翻译
  作者：Kim, Ji Yeon; Lee, Jong An; Ahn, Jung Ho; Lee, Sang Yup
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Institute of Science & Technology (KIST)
  摘要：Succinic acid (SA), a dicarboxylic acid of industrial importance, can be efficiently produced by metabolically engineered Mannheimia succiniciproducens. Although the importance of magnesium (Mg2+) ion on SA production has been evident from our previous studies, the role of Mg2+ ion remains largely unexplored. In this study, we investigated the impact of Mg2+ ion on SA production and developed a hyper- SA producing strain of M. succiniciproducens by reconstructing the Mg2+ ion transport system....
• Early archaeological evidence of wheat and cotton from medieval Ile-Ife, Nigeria AI翻译
  作者：Logan, Amanda L.; Chouin, Gerard L.; Ogunfolakan, Adisa B.; Lally, Shannon; Kuma, Dela; Kuto, Eli; Bell, Kristina; Rosenzweig, Melissa S.; Beldados, Alemseged
  作者单位：Northwestern University; William & Mary; Obafemi Awolowo University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：This study reports the earliest directly dated occurrence of archaeological wheat and cotton in the humid forests of West Africa. These are the first archaeobotanical results from the medieval urban center of Ile- Ife, southwestern Nigeria, best known for its famous artworks. Both wheat and cotton likely spread through trans- Saharan trade networks that laid the foundation for later European trade systems. Forty- eight (48) grains of free- threshing wheat (Triticum aestivum/durum) represent th...