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作者：Davis, Christina L.; Li, Jialu; Miyano, Sayumi
作者单位：Harvard University; Harvard University
摘要：States have long used economic sanctions in response to violations of international law as a strategy to restore order. Increasingly, firms also reject doing business with violators. In response to the war in Ukraine, hundreds of multinational corporations voluntarily withdrew from Russia, even when policymakers were still debating the extent of sanctions. How did firm managers evaluate whether to withdraw from the Russian market? Using a survey experiment with Japanese firm managers conducted...
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作者：de la Malla, Cristina; Poletti, Martina
作者单位：University of Barcelona; University of Rochester; University of Rochester; University of Rochester
摘要：Humans explore visual scenes by alternating short fixations with saccades directing the fovea to points of interest. During fixation, the visual system not only examines the foveal stimulus at high resolution, but it also processes the extrafoveal input to plan the next saccade. Although foveal analysis and peripheral selection occur in parallel, little is known about the temporal dynamics of foveal and peripheral processing upon saccade landing, during fixation. Here we investigate whether th...
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作者：Liu, Shih - Hsien; Rukmani, Shalini J.; Mohan, Mood; Yu, Yan; Vural, Derya; Johnson, Donna A.; Copenhaver, Katie; Bhagia, Samarthya; Lamm, Meghan E.; Li, Kai; Chen, Jihua; Goswami, Monojoy; Smith, Micholas Dean; Petridis, Loukas; Ozcan, Soydan; Smith, Jeremy C.
作者单位：University of Tennessee System; University of Tennessee Knoxville; United States Department of Energy (DOE); Oak Ridge National Laboratory; University of Tennessee System; University of Tennessee Knoxville; United States Department of Energy (DOE); Oak Ridge National Laboratory; Marmara University; University of Maine System; University of Maine Orono; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences; United States Department of Energy (DOE); Oak Ridge National Laboratory
摘要：The outstanding mechanical properties, light weight, and biodegradability of cellulose nanofibrils (CNFs) make them promising components of renewable and sustainable next-generation reinforced composite biomaterials and bioplastics. Manufacturing CNFs at a pilot scale requires disc-refining fibrillation of dilute cellulose fibers in aqueous pulp suspensions to shear the fibers apart into their nanodimensional forms, which is, however, an energy-intensive process. Here, we used atomistic molecu...
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作者：Zhang, Yuchao; Sun, Yishan; Shi, Jungang; Xu, Peng; Wang, Yingli; Liu, Jianping; Gong, Xinyu; Wang, Yaru; Tang, Yubin; Liu, Haobo; Zhou, Xindi; Lin, Zhiqiao; Baba, Otto; Morita, Tsuyoshi; Yu, Biao; Pan, Lifeng
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tokushima University
摘要：Autophagy of glycogen (glycophagy) is crucial for the maintenance of cellular glucose homeostasis and physiology in mammals. STBD1 can serve as an autophagy receptor to mediate glycophagy by specifically recognizing glycogen and relevant key autophagic factors, but with poorly understood mechanisms. Here, we systematically characterize the interactions of STBD1 with glycogen and related saccharides, and determine the crystal structure of the STBD1 CBM20 domain with maltotetraose, uncovering a ...
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作者：Gualdani, Roberta; Barbeau, Solene; Yuan, Jun - Hui; Jacobs, Deborah S.; Gailly, Philippe; Dib-Hajj, Sulayman D.; Waxman, Stephen G.
作者单位：Universite Catholique Louvain; Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary
摘要：The factors that contribute to pain after nerve injury remain incompletely understood. Laser- assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) are common surgical techniques to correct refractive errors. After LASIK or PRK, a subset of patients suffers intense and persistent pain, of unknown origin, described by patients as feeling like shards of glass in their eye. Here, we evaluated a TRPV1 variant, p.V527M, found in a 49- y- old woman who developed corneal pain ...
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作者：Huang, Baolian; Yin, Te; Fu, Shuilian; Liu, Lina; Yang, Chen; Zhou, Lulu; Liu, Xing; Zhuang, Hongqin; Cao, Zhiting; Hua, Zichun
作者单位：China Pharmaceutical University; Nanjing University
摘要：Oral delivery of proteins faces challenges due to the harsh conditions of the gastrointestinal (GI) tract, including gastric acid and intestinal enzyme degradation. Permeation enhancers are limited in their ability to deliver proteins with high molecular weight and can potentially cause toxicity by opening tight junctions. To overcome these challenges, we propose the use of montmorillonite (MMT) as an adjuvant that possesses both inflammation- oriented abilities and the ability to regulate gut...
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作者：Hayakawa-Yano, Yoshika; Furukawa, Takako; Matsuo, Tsuyoshi; Ogasawara, Takahisa; Nogami, Masahiro; Yokoyama, Kazumasa; Yugami, Masato; Shinozaki, Munehisa; Nakamoto, Chihiro; Sakimura, Kenji; Koyama, Akihide; Ogi, Kazuhiro; Onodera, Osamu; Takebayashi, Hirohide; Okano, Hideyuki; Yano, Masato
作者单位：Niigata University; Keio University; Keio University; Takeda Pharmaceutical Company Ltd; Niigata University; Niigata University; Niigata University
摘要：Many RNA- binding proteins (RBPs) are linked to the dysregulation of RNA metabolism in motor neuron diseases (MNDs). However, the molecular mechanisms underlying MN vulnerability have yet to be elucidated. Here, we found that such an RBP, Quaking5 (Qki5), contributes to formation of the MN- specific transcriptome profile, termed MN- ness, through the posttranscriptional network and maintenance of the mature MNs. Immunohistochemical analysis and single- cell RNA sequencing (scRNA- seq) revealed...
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作者：Taira, Masanori; Ozato, Keiko; Harland, Richard M.; Moody, Sally A.; Saint-Jeannet, Jean-Pierre
作者单位：Chuo University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); University of California System; University of California Berkeley; George Washington University; New York University
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作者：Webber, Quinn
作者单位：University of Guelph
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作者：Armanetti, Paolo; Locatelli, Irene; Venegoni, Chiara; Alchera, Elisa; Campanella, Beatrice; Pederzoli, Filippo; Maturi, Mirko; Locatelli, Erica; Tortorella, Silvia; Curnis, Flavio; Corti, Angelo; Luciano, Roberta; Onor, Massimo; Salonia, Andrea; Montorsi, Francesco; Moschini, Marco; Popov, Viktor; Jose, Jithin; Franchini, Mauro Comes; Ooi, Ean Hin; Menichetti, Luca; Alfano, Massimo
作者单位：Consiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale delle Ricerche (CNR); Vita-Salute San Raffaele University; University of Bologna; Fujifilm Corporation; Monash University; Monash University Malaysia
摘要：Residual nonvisible bladder cancer after proper treatment caused by technological and therapeutic limitations is responsible for tumor relapse and progression. This study aimed to demonstrate the feasibility of a solution for simultaneous detection and treatment of bladder cancer lesions smaller than one millimeter. The alpha 5f31 integrin was identified as a specific marker in 81% of human high- grade nonmuscle invasive bladder cancers and used as a target for the delivery of targeted gold na...
