40期

最新文章

• Accurate prediction of discontinuous crack paths in random porous media via a generative deep learning model AI翻译
  作者：He, Yuxiang; Tan, Yu; Yang, Mingshan; Wang, Yongbin; Xu, Yangguang; Yuan, Jianghong; Li, Xiangyu; Chen, Weiqiu; Kang, Guozheng
  作者单位：Southwest Jiaotong University; Chengdu University of Technology; Zhejiang University
  摘要：Pore structures provide extra freedoms for the design of porous media, leading to desirable properties, such as high catalytic rate, energy storage efficiency, and specific strength. This unfortunately makes the porous media susceptible to failure. Deep understanding of the failure mechanism in microstructures is a key to customizing high- performance crack- resistant porous media. However, solving the fracture problem of the porous materials is computationally intractable due to the highly co...
• Alveolar macrophage function is impaired following inhalation of berry e- cigarette vapor AI翻译
  作者：Kulle, Amelia; Li, Ziyi; Kwak, Ashley; Mancini, Mathieu; Young, Daniel; Avizonis, Daina Zofija; Groleau, Marc; Baglole, Carolyn J.; Behr, Marcel A.; King, Irah L.; Divangahi, Maziar; Langlais, David; Wang, Jing; Blagih, Julianna; Penz, Erika; Dufour, Antoine; Thanabalasuriar, Ajitha
  作者单位：McGill University; McGill University; University of Calgary; McGill University; McGill University; McGill University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Universite de Montreal; University of Saskatchewan
  摘要：In the lower respiratory tract, the alveolar spaces are divided from the bloodstream and the external environment by only a few microns of interstitial tissue. Alveolar macrophages (AMs) defend this delicate mucosal surface from invading infections by regularly patrolling the site. AMs have three behavior modalities to achieve this goal: extending cell protrusions to probe and sample surrounding areas, squeezing the whole cell body between alveoli, and patrolling by moving the cell body around...
• miR-96-5p expression is sufficient to induce and maintain the senescent cell fate in the absence of stress AI翻译
  作者：Santiago, Fernando E.; Adige, Tanvi; Mahmud, Shamsed; Dong, Xiao; Niedernhofer, Laura J.; Robbins, Paul D.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Senescence is a cell fate driven by different types of stress that results in exit from the cell cycle and expression of an inflammatory senescence- associated secretory phenotype (SASP). Here, we demonstrate that stable overexpression of miR-96-5p was sufficient to induce cellular senescence in the absence of genotoxic stress, inducing expression of certain markers of early senescence including SASP factors while repressing markers of deep senescence including LINE- 1 and type 1 interferons. ...
• PUFAs regulate SREBP1c through phosphorylation of Insig2 AI翻译
  作者：Xiao, Xu; Tontonoz, Peter
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
• Repetition dynamically and rapidly increases cortical, but not hippocampal, offline reactivation AI翻译
  作者：Yu, Wangjing; Zadbood, Asieh; Chanales, Avi J. H.; Davachi, Lila
  作者单位：Columbia University; New York University; Nathan Kline Institute for Psychiatric Research
  摘要：No sooner is an experience over than its neural representation begins to be transformed through memory reactivation during offline periods. The lion's share of prior research has focused on understanding offline reactivation within the hippocampus. However, it is hypothesized that consolidation processes involve offline reactivation in cortical regions as well as coordinated reactivation in the hippocampus and cortex. Using fMRI, we presented novel and repeated paired associates to participant...
• Intercellular friction and motility drive orientational order in cell monolayers AI翻译
  作者：Chiang, Michael; Hopkins, Austin; Loewe, Benjamin; Marchetti, M. Cristina; Marenduzzo, Davide
  作者单位：University of Edinburgh; University of California System; University of California Santa Barbara; Pontificia Universidad Catolica de Chile
  摘要：Spatiotemporal patterns in multicellular systems are important to understanding tissue dynamics, for instance, during embryonic development and disease. Here, we use a multiphase field model to study numerically the behavior of a near-confluent monolayer of deformable cells with intercellular friction. Varying friction and cell motility drives a solid-liquid transition, and near the transition boundary, we find the emergence of local nematic order of cell deformation driven by shear-aligning c...
• A geometric-tension-dynamics model of epithelial convergent extension AI翻译
  作者：Claussen, Nikolas H.; Brauns, Fridtjof; Shraiman, Boris I.
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara
  摘要：Convergent extension of epithelial tissue is a key motif of animal morphogenesis. On a coarse scale, cell motion resembles laminar fluid flow; yet in contrast to a fluid, epithelial cells adhere to each other and maintain the tissue layer under actively generated internal tension. To resolve this apparent paradox, we formulate a model in which tissue flow in the tension-dominated regime occurs through adiabatic remodeling of force balance in the network of adherens junctions. We propose that t...
• RIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1 AI翻译
  作者：Zhang, Jing; Wei, Yuehan; Yue, Yangbo; Jiao, Huike; Wu, Yan; Fu, Wan; Lin, Keng - Mean; Lu, Christopher; Mou, Shan; Zhong, Qing
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：One of the most critical axes for cell fate determination is how cells respond to excessive reactive oxygen species (ROS)-oxidative stress. Extensive lipid peroxidation commits cells to death via a distinct cell death paradigm termed ferroptosis. However, the molecular mechanism regulating cellular fates to distinct ROS remains incompletely understood. Through siRNA against human receptor- interacting protein kinase (RIPK) family members, we found that RIPK4 is crucial for oxidative stress and...
• QnAs with Scott E. Heatwole and Robert F. Pfaff AI翻译
  作者：Hardcastle, Matthew
  摘要：The physicist Robert H. Goddard is considered one of the founding fathers of rocketry and space flight. Among his early work was an article published in 1920 in PNAS titled, The possibilities of the rocket in weather forecasting ( 1 ). In this now-classic article, Goddard outlined the potential use of rockets to collect high-altitude data on atmospheric conditions to improve weather forecasting. Goddard estimated that rockets carrying recording instruments could reach a height of 10 kilometers...
• Global fishing patterns amplify human exposures to methylmercury AI翻译
  作者：Li, Mi-Ling; Thackray, Colin P.; Lam, Vicky W. Y.; Cheung, William W. L.; Sunderland, Elsie M.
  作者单位：University of Delaware; Harvard University; University of British Columbia; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Global pollution has exacerbated accumulation of toxicants like methylmercury (MeHg) in seafood. Human exposure to MeHg has been associated with long- term neurodevelopmental delays and impaired cardiovascular health, while many micro- nutrients in seafood are beneficial to health. The largest MeHg exposure source for many general populations originates from marine fish that are harvested from the global ocean and sold in the commercial seafood market. Here, we use high- resolution catch data ...