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作者：Feng, Li; Gong, Huiying; Zhang, Shen; Liu, Xiang; Wang, Yu; Che, Jincan; Dong, Ang; Griffin, Christopher H.; Gragnoli, Claudia; Wu, Jie; Yau, Shing-Tung; Wu, Rongling
作者单位：Chinese Academy of Fishery Sciences; Fishery Engineering Research Institute, CAFS; Beijing Forestry University; Tsinghua University; Nankai University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Creighton University; Tsinghua University
摘要：Interactions among the underlying agents of a complex system are not only limited to dyads but can also occur in larger groups. Currently, no generic model has been developed to capture high- order interactions (HOI), which, along with pairwise interactions, portray a detailed landscape of complex systems. Here, we integrate evolutionary game theory and behavioral ecology into a unified statistical mechanics framework, allowing all agents (modeled as nodes) and their bidirectional, signed, and...
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作者：Levin, Ido; Sadaba, Naroa; Nelson, Alshakim; Keller, Sarah L.
作者单位：University of Washington; University of Washington Seattle
摘要：Unlike human intestines, which are long, hollow tubes, the intestines of sharks and rays contain interior helical structures surrounding a cylindrical hole. One function of these structures may be to create asymmetric flow, favoring passage of fluid down the digestive tract, from anterior to posterior. Here, we design and 3D print biomimetic models of shark intestines, in both rigid and deformable materials. We use the rigid models to test which physical parameters of the interior helices (the...
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作者：Regnard, Sarah; Otani, Masahiko; Keruzore, Marc; Teinturier, Alizee; Blondel, Marc; Kawakami, Naoto; Krapp, Anne; Colcombet, Jean
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Cite; INRAE; Meiji University; CHU Brest; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bretagne Occidentale; INRAE; Universite Paris Saclay; AgroParisTech
摘要：Seed dormancy corresponds to a reversible blockage of germination. Primary dormancy is established during seed maturation, while secondary dormancy is set up on the dispersed seed, following an exposure to unfavorable factors. Both dormancies are relieved in response to environmental factors, such as light, nitrate, and coldness. Quantitive Trait Locus (QTL) analyses for preharvest sprouting identified MKK3 kinase in cereals as a player in dormancy control. Here, we showed that MKK3 also plays...
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作者：Shaheen, Basamat S.; Huynh, Kenny; Quan, Yujie; Choudhry, Usama; Gnabasik, Ryan; Xiang, Zeyu; Goorsky, Mark; Liao, Bolin
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Los Angeles
摘要：Semiconductor heterojunctions have gained significant attention for efficient optoelectronic devices owing to their unique interfaces and synergistic effects. Interaction between charge carriers with the heterojunction plays a crucial role in determining device performance, while its spatial-temporal mapping remains lacking. In this study, we employ scanning ultrafast electron microscopy (SUEM), an emerging technique that combines high spatial-temporal resolution and surface sensitivity, to in...
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作者：Mair, Devin B.; Tsui, Jonathan H.; Higashi, Ty; Koenig, Paul; Dong, Zhipeng; Chen, Jeffrey F.; Meir, Jessica U.; Smith, Alec S. T.; Lee, Peter H. U.; Ahn, Eun Hyun; Countryman, Stefanie; Sniadecki, Nathan J.; Kim, Deok - Ho
作者单位：Johns Hopkins University; University of Washington; University of Washington Seattle; University of Colorado System; University of Colorado Boulder; National Aeronautics & Space Administration (NASA); University of Washington; University of Washington Seattle; Brown University; Johns Hopkins University; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
摘要：With current plans for manned missions to Mars and beyond, the need to better understand, prevent, and counteract the harmful effects of long- duration spaceflight on the body is becoming increasingly important. In this study, an automated heart- on- a- chip platform was flown to the International Space Station on a 1-mo mission during which contractile cardiac function was monitored in real- time. Upon return to Earth, engineered human heart tissues (EHTs) were further analyzed with ultrastru...
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作者：Maiuri, Tamara; Bazan, Carlos Barba; Harding, Rachel J.; Begeja, Nola; Kam, Tae-In; Byrne, Lauren M.; Rodrigues, Filipe B.; Warner, Monica M.; Neuman, Kaitlyn; Mansoor, Muqtasid; Badiee, Mohsen; Dasovich, Morgan; Wang, Keona; Thompson, Leslie M.; Leung, Anthony K. L.; Andres, Sara N.; Wild, Edward J.; Dawson, Ted M.; Dawson, Valina L.; Arrowsmith, Cheryl H.; Truant, Ray
作者单位：McMaster University; University of Toronto; University of Toronto; Structural Genomics Consortium; University of Toronto; Johns Hopkins University; Johns Hopkins University; University of London; University College London; McMaster University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of California System; University of California Irvine; University of California System; University of California Irvine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto
摘要：Huntington disease (HD) is a genetic neurodegenerative disease caused by cytosine, adenine, guanine (CAG) expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract in the HTT protein. Age at disease onset correlates to CAG repeat length but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health pathways. Clinical studies show elevated DNA damage in HD, even at ...
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作者：Shukla, Vinay; Moreno-Irusta, Ayelen; Varberg, Kaela M.; Kuna, Marija; Iqbal, Khursheed; Galligos, Anna M.; Aplin, John D.; Choudhury, Ruhul H.; Okae, Hiroaki; Arima, Takahiro; Soares, Michael J.
作者单位：University System of Maryland; University of Maryland Baltimore; Children's Mercy Hospital; Oklahoma State University System; Oklahoma State University - Stillwater; Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center; University of Manchester; University of Manchester; Kumamoto University; Tohoku University; Children's Mercy Hospital; University of Kansas; University of Kansas Medical Center
摘要：Trophoblast stem (TS) cells have the unique capacity to differentiate into specialized cell types, including extravillous trophoblast (EVT) cells. EVT cells invade into and transform the uterus where they act to remodel the vasculature facilitating the redirection of maternal nutrients to the developing fetus. Disruptions in EVT cell development and function are at the core of pregnancy- related disease. WNT- activated signal transduction is a conserved regulator of morphogenesis of many organ...
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作者：Kobylkov, Dmitry; Salva, Orsola Rosa -; Zanon, Mirko; Vallortigara, Giorgio
作者单位：University of Trento
摘要：Shortly after birth, both na & iuml;ve animals and newborn babies exhibit a spontaneous attraction to faces and face- like stimuli. While neurons selectively responding to faces have been found in the inferotemporal cortex of adult primates, face- selective domains in the brains of young monkeys seem to develop only later in life after exposure to faces. This has fueled a debate on the role of experience in the development of face- detector mechanisms, since face preferences are well documente...
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作者：Richardson, Jon; Hoversten, Isabelle P.; Zuk, Marlene
作者单位：University of Minnesota System; University of Minnesota Twin Cities
摘要：Same- sex sexual behavior (SSB) is widespread among animals and is often treated as an evolutionary anomaly or mistake. An alternative view is that SSB occurs because individuals have broader or more permissive mating filters. A broader filter means directing courtship toward anything that resembles a potential mate, while a narrower filter means having stricter criteria about when to court. Broader filters help ensure animals do not miss out on mating opportunities. However, it may be advanta...
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作者：Bitter, Ryan M.; Zimmerman, Maxwell I.; Summers, Brock T.; Pinkner, Jerome S.; Dodson, Karen W.; Hultgren, Scott J.; Yuan, Peng
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Gram- negative bacteria produce chaperone-usher pathway pili, which are extracellular protein fibers tipped with an adhesive protein that binds to a receptor with stereochemical specificity to determine host and tissue tropism. The outer- membrane usher protein, together with a periplasmic chaperone, assembles thousands of pilin subunits into a highly ordered pilus fiber. The tip adhesin in complex with its cognate chaperone activates the usher to allow extrusion across the outer membrane. The...
