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作者：Wang, Zengming; Yu, Haolan; Bao, Wei; Qu, Min; Wang, Yan; Zhang, Liandong; Liu, Xubing; Liu, Chen; He, Miaoxia; Li, Jing; Dong, Zhenyang; Zhang, Yun; Yang, Bo; Hou, Jianguo; Xu, Chuanliang; Wang, Linhui; Li, Xin; Gao, Xu; Yang, Chenghua
作者单位：Naval Medical University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Naval Medical University; Shenzhen Bay Laboratory; Shanghai Jiao Tong University
摘要：Building upon our previous investigation of genomic, epigenomic, and transcriptomic profiles of prostate cancer in China, we conducted a comprehensive analysis of proteomic and phosphoproteomic profiles of 82 tumor tissues and matched adjacent normal tissues from 41 Chinese patients with localized prostate cancer. We identified three distinct proteomic subtypes with significant difference in both molecular features and clinical prognosis. Notably, these proteomic subtypes exhibited a parallel ...
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作者：Gervais, Adrian; Le Floc'h, Corentin; Le Voyer, Tom; Bizien, Lucy; Bohlen, Jonathan; Celmeli, Fatih; Al Qureshah, Fahd; Masson, Cecile; Rosein, Jeremi; Chbihi, Marwa; Levy, Romain; Castagnoli, Riccardo; Rothenbuhler, Anya; Jouanguy, Emmanuelle; Zhang, Qian; Zhang, Shen - Ying; Beziat, Vivien; Bustamante, Jacinta; Puela, Anne; Bastard, Paul; Casanova, Jean- Laurent
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Rockefeller University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; University of Pavia; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
摘要：Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-alpha,-beta, and/or-omega can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition. We stimulate whole blood from healthy individuals and patients with either inborn errors of type I IFN immunity or auto-Abs against type I IFNs with glycosylated human IFN-alpha 2,-beta, or-omega. As controls, we add a monoclonal antibody (mAb) blocking the type I IFN receptors ...
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作者：Kamat, Rupini, V; Sharpe, Aaron L.; Pendharkar, Mihir; Hu, Jenny; Tran, Steven J.; Zaborski Jr, Gregory; Hocking, Marisa; Finney, Joe; Watanabe, Kenji; Taniguchi, Takashi; Kastner, Marc A.; Mannix, Andrew J.; Heinz, Tony; Goldhaber-Gordon, David
作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; National Institute for Materials Science; Massachusetts Institute of Technology (MIT)
摘要：The electronic properties of moir & eacute; heterostructures depend sensitively on the relative orientation between layers of the stack. For example, near-magic-angle twisted bilayer graphene (TBG) commonly shows superconductivity, yet a TBG sample with one of the graphene layers rotationally aligned to a hexagonal Boron Nitride (hBN) cladding layer provided experimental observation of orbital ferromagnetism. To create samples with aligned graphene/hBN, researchers often align edges of exfolia...
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作者：Mcnutt, Marcia
作者单位：National Academies of Sciences, Engineering & Medicine
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作者：Rusch, T. Konstantin; Kirk, Nathan; Bronstein, Michael M.; Lemieux, Christiane; Rus, Daniela
作者单位：Massachusetts Institute of Technology (MIT); University of Waterloo; University of Oxford
摘要：Discrepancy is a well-known measure for the irregularity of the distribution of a point set. Point sets with small discrepancy are called low discrepancy and are known to efficiently fill the space in a uniform manner. Low-discrepancy points play a central role in many problems in science and engineering, including numerical integration, computer vision, machine perception, computer graphics, machine learning, and simulation. In this work, we present a machine learning approach to generate a n...
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作者：Busoms, Silvia; da Silva, Ana C.; Escola, Gloria; Abdilzadeh, Raziyeh; Curran, Emma; Bollmann-Giolai, Anita; Bray, Sian; Wilson, Michael; Poschenrieder, Charlotte; Yant, Levi
作者单位：Autonomous University of Barcelona; University of Nottingham; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of Nottingham; Charles University Prague; University of Cambridge; Max Planck Society
摘要：It is normally supposed that populations of the same species should evolve shared mechanisms of adaptation to common stressors due to evolutionary constraint. Here, we describe a system of within- species local adaptation to coastal habitats, Brassica fruticulosa, and detail surprising strategic variability in adaptive responses to high salinity. These different adaptive responses in neighboring populations are evidenced by transcriptomes, diverse physiological outputs, and distinct genomic se...
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作者：Chai, Liraz; Zaburdaev, Vasily; Kolter, Roberto
作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Queensland University of Technology (QUT); University of Erlangen Nuremberg; Harvard University; Harvard Medical School
摘要：Modern molecular microbiology elucidates the organizational principles of bacterial biofilms via detailed examination of the interplay between signaling and gene regulation. A complementary biophysical approach studies the mesoscopic dependencies at the cellular and multicellular levels with a distinct focus on intercellular forces and mechanical properties of whole biofilms. Here, motivated by recent advances in biofilm research and in other, seemingly unrelated fields of biology and physics,...
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作者：Liu, Wen; Yan, Minyi; King-Jones, Kirst
作者单位：University of Alberta
摘要：The prothoracic gland (PG) is a major insect endocrine organ. It is the principal source of insect steroid hormones, and critical for key developmental events such as the molts, the establishment of critical weight (CW), pupation, and sexual maturation. However, little is known about the developmental processes that regulate PG morphology. In this study, we identified soul, which encodes a PG- specific basic helix-loop-helix (bHLH) transcription factor. We demonstrate that Tap, also a bHLH pro...
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作者：Heatwole, Scott E.
作者单位：National Aeronautics & Space Administration (NASA)
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作者：Hartig, Elli I.; Day, Matthew; Jarysta, Amandine; Tarchini, Basile
作者单位：Tufts University; Jackson Laboratory
摘要：The hair bundle, or stereocilia bundle, is the mechanosensory compartment of hair cells (HCs) in the inner ear. To date, most mechanistic studies have focused on stereocilia bundle morphogenesis, and it remains unclear how this organelle critical for hearing preserves its precise dimensions during life in mammals. The GPSM2-GNAI complex occupies the distal tip of stereocilia in the tallest row and is required for their elongation during development. Here, we ablate GPSM2-GNAI in adult mouse HC...
