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作者：Bartolucci, Silvia; Caccioli, Fabio; Caravelli, Francesco; Vivo, Pierpaolo
作者单位：University of London; University College London; Imperial College London; University of London; London School Economics & Political Science; United States Department of Energy (DOE); Los Alamos National Laboratory; University of London; King's College London
摘要：The Katz centrality of a node in a complex network is a measure of the node's importance as far as the flow of information across the network is concerned. For ensembles of locally tree-like undirected random graphs, this observable is a random variable. Its full probability distribution is of interest but difficult to handle analytically because of its global character and its definition in terms of a matrix inverse. Leveraging a fast Gaussian Belief Propagation-Cavity algorithm to solve line...
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作者：Curtis, Zachary; Escudeiro, Pedro; Mallon, John; Leland, Olivia; Rados, Theopi; Dodge, Ashley; Andre, Katherine; Kwak, Jasmin; Yun, Kun; Isaac, Berith; Pastor, Mar Martinez; Schmid, Amy K.; Pohlschroder, Mechthild; Alva, Vikram; Bisson, Alex
作者单位：Brandeis University; University of Pennsylvania; Duke University
摘要：Bactofilins are rigid, nonpolar bacterial cytoskeletal filaments that link cellular processes to specific curvatures of the cytoplasmic membrane. Although homologs of bactofilins have been identified in archaea and eukaryotes, functional studies have remained confined to bacterial systems. Here, we characterize representatives of two families of archaeal bactofilins from the pleomorphic archaeon Haloferax volcanii, halofilin A straight bundles. HalA polymers are highly dynamic and accumulate a...
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作者：Dibari, Leonardo; Bisardi, Matteo; Cotogno, Sabrina; Weigt, Martin; Zamponi, Francesco
作者单位：Polytechnic University of Turin; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Sapienza University Rome
摘要：We introduce a data-driven epistatic model of protein evolution, capable of generating evolutionary trajectories spanning very different time scales reaching from individual mutations to diverged homologs. Our in silico evolution encompasses random nucleotide mutations, insertions and deletions, and models selection using a fitness landscape, which is inferred via a generative probabilistic model for protein families. We show that the proposed framework accurately reproduces the sequence stati...
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作者：Garbowski, Magda; Laughlin, Daniel C.; Blumenthal, Dana M.; Sofaer, Helen R.; Barnett, David T.; Beaury, Evelyn M.; Buonaiuto, Daniel M.; Corbin, Jeffrey D.; Dukes, Jeffrey S.; Early, Regan; Nebhut, Andrea N.; Petri, Lais; Vila, Montserrat; Pearse, Ian S.
作者单位：University of Wyoming; United States Department of Agriculture (USDA); United States Department of the Interior; United States Geological Survey; Princeton University; University of Massachusetts System; University of Massachusetts Amherst; United States Department of the Interior; United States Geological Survey; Union College; Carnegie Institution for Science; Stanford University; Stanford University; University of Exeter; Michigan State University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); University of Sevilla; United States Department of the Interior; United States Geological Survey
摘要：Despite decades of research documenting the consequences of naturalized and invasive plant species on ecosystem functions, our understanding of the functional underpinnings of these changes remains rudimentary.This is partially due to ineffective scaling of trait differences between native and naturalized species to whole plant communities. Working with data from over 75,000 plots and over 5,500 species from across the United States, we show that changes in the functional composition of commun...
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作者：Qu, Zhen; Jacob, Daniel J.; Bloom, A. Anthony; Worden, John R.; Parker, Robert J.; Boesch, Hartmut
作者单位：North Carolina State University; Harvard University; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Leicester; University of Leicester; University of Bremen
摘要：Atmospheric methane concentrations rose rapidly over the past decade and surged in 2020-2022 but the causes have been unclear. We find from inverse analysis of GOSAT satellite observations that emissions from the wet tropics drove the 2010-2019 increase and the subsequent 2020-2022 surge, while emissions from northern mid- latitudes decreased. The 2020-2022 surge is principally contributed by emissions in Equatorial Asia (43%) and Africa (30%). Wetlands are the major drivers of the 2020-2022 e...
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作者：Wang, Faming; Wang, Lijuan; Lei, Tze- Huan
作者单位：Xi'an University of Science & Technology; Xi'an Polytechnic University
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作者：Han, Jian; Song, Yangyang; Xie, Jinghe; Tano, Vincent; Shen, Haoqing; Gan, Wei Liang; Ng, Larry; Ng, Bryan Yik Loong; Ng, Vanessa Hui En; Sui, Xiaohui; Tang, Sze Jing; Chen, Leilei
作者单位：National University of Singapore; National University of Singapore
摘要：N6- methyladenosine (m6A) RNA methylation is a prevalent RNA modification that significantly impacts RNA metabolism and cancer development. Maintaining the global m6A levels in cancer cells relies on RNA accessibility to methyltransferases and the availability of the methyl donor S- adenosylmethionine (SAM). Here, we reveal that death associated protein 3 (DAP3) plays a crucial role in preserving m6A levels through two distinct mechanisms. First, although DAP3 is not a component of the m6A wri...
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作者：Mendieta, John Pablo; Tu, Xiaoyu; Jiang, Daiquan; Yan, Haidong; Zhang, Xuan; Marand, Alexandre P.; Zhong, Silin; Schmitz, Robert J.
作者单位：University of Michigan System; University of Michigan; University System of Georgia; University of Georgia; Shanghai Jiao Tong University; Chinese University of Hong Kong
摘要：While considerable knowledge exists about the enzymes pivotal for C4 photosynthesis, much less is known about the cis- regulation important for specifying their expression in distinct cell types. Here, we use single- cell- indexed ATAC-seq to identify cell- type- specific accessible chromatin regions (ACRs) associated with C4 enzymes for five different grass species. This study spans four C4 species, covering three distinct photosynthetic subtypes: Zea mays and Sorghum bicolor (NADP- dependent...
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作者：Kamra, Lina Johnsen; Lu, Bo; Linder, Jacob; Tanaka, Yukio; Nagaosa, Naoto
作者单位：Norwegian University of Science & Technology (NTNU); Autonomous University of Madrid; Autonomous University of Madrid; Massachusetts Institute of Technology (MIT); Tianjin University; Nagoya University; Nagoya University; RIKEN; RIKEN
摘要：The Majorana fermion offers fascinating possibilities such as non-Abelian statistics , nonlocal robust qubits , hunting it is one of the most important topics in current condensed matter physics. Most of the efforts have been focused on the Majorana bound state at zero energy in terms of scanning tunneling spectroscopy searching for the quantized conductance. On the other hand, a chiral Majorana edge channel appears at the surface of a three-dimensional topological insulator when engineering a...
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作者：Radhakrishnan, Harikrishnan; Newmyer, Sherri L.; Javitz, Harold S.; Bhatnagar, Parijat
作者单位：SRI International; SRI International
摘要：The CD4 T cell, when engineered with a chimeric antigen receptor (CAR) containing specific intracellular domains, has been transformed into a zero-order drug-delivery platform. This introduces the capability of prolonged, disease-specific engineered protein biologics production, at the disease site. Experimental findings demonstrate that CD4 T cells offer a solution when modified with a CAR that includes 4-1BB but excludes CD28 intracellular domain. In this configuration, they achieve similar ...
