40期

最新文章

• Effect of a cash transfer intervention on memory decline and dementia probability in older adults in rural South Africa AI翻译
  作者：Rosenberg, Molly; Beidelman, Erika T.; Chen, Xiwei; Kabudula, Chodziwadziwa Whiteson; Pettifor, Audrey; Bassil, Darina T.; Berkman, Lisa; Kahn, Kathleen; Tollman, Stephen; Kobayashi, Lindsay C.
  作者单位：Indiana University System; Indiana University Bloomington; South African Medical Research Council; University of Witwatersrand; Indiana University System; Indiana University Bloomington; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Harvard University; Harvard T.H. Chan School of Public Health; Umea University; University of Michigan System; University of Michigan
  摘要：Evidence on cash transfers as a population- level intervention to support healthy cognitive aging in low- income settings is sparse. We assessed the effect of a cash transfer intervention on cognitive aging outcomes in older South African adults. We leveraged the overlap in the sampling frames of a Phase 3 randomized cash transfer trial [HIV Prevention Trial Network (HPTN) 068, 2011-2015] and an aging cohort [Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community (HAALSI), 20...
• Causal message-passing for experiments with unknown and general network interference AI翻译
  作者：Shirani, Sadegh; Bayati, Mohsen
  作者单位：Stanford University
  摘要：Randomized experiments are a powerful methodology for data-driven evaluation of decisions or interventions. Yet, their validity may be undermined by network interference. This occurs when the treatment of one unit impacts not only its outcome but also that of connected units, biasing traditional treatment effect estimations. Our study introduces a framework to accommodate complex and unknown network interference, moving beyond specialized models in the existing literature. Our framework, terme...
• Small field chaos in spin glasses: Universal predictions from the ultrametric tree and comparison with numerical simulations AI翻译
  作者：Aguilar-Janita, Miguel; Franz, Silvio; Martin-Mayor, Victor; Moreno-Gordo, Javier; Parisi, Giorgio; Ricci-Tersenghi, Federico; Ruiz-Lorenzo, Juan J.
  作者单位：Universidad Rey Juan Carlos; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - UAM - Institut de Fisica Teorica (IFT); Complutense University of Madrid; University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - UAM - Institut de Fisica Teorica (IFT); Universidad de Extremadura; Universidad de Extremadura; Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR); Sapienza University Rome; Istituto Nazionale di Fisica Nucleare (INFN)
  摘要：Replica symmetry breaking (RSB) for spin glasses predicts that the equilibrium configuration at two different magnetic fields are maximally decorrelated. We show that this theory presents quantitative predictions for this chaotic behavior under the application of a vanishing external magnetic field, in the crossover region where the root field intensity scales proportionally to 1/ N , being N the system size. We show that RSB theory provides universal predictions for chaotic behavior: They dep...
• Reply to Wang et al.: Body size and composition are the primary contributors to human thermoregulatory variation by sex AI翻译
  作者：Brychta, Robert J.; Lamunion, Samuel R.; Courville, Amber B.; Reitman, Marc L.; Cypess, Aaron M.; Chen, Kong Y.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
• Cell- type- specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex AI翻译
  作者：McCollum, Mason; Manning, Abbey; Bender, Philip T. R.; Mendelson, Benjamin Z.; Anderson, Charles T.
  作者单位：West Virginia University
  摘要：Stimulus- specific adaptation is a hallmark of sensory processing in which a repeated stimulus results in diminished successive neuronal responses, but a deviant stimulus will still elicit robust responses from the same neurons. Recent work has established that synaptically released zinc is an endogenous mechanism that shapes neuronal responses to sounds in the auditory cortex. Here, to understand the contributions of synaptic zinc to deviance detection of specific neurons, we performed wide- ...
• Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity AI翻译
  作者：Abu-Remaileh, Muhannad; Persky, Nicole S.; Lee, Yenarae; Root, David E.; Kaelin Jr, William G.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Howard Hughes Medical Institute
  摘要：Loss- of- function germline von Hippel-Lindau (VHL) tumor suppressor mutations cause VHL disease, which predisposes individuals to kidney cancer, hemangioblastomas, and paragangliomas. The risk that a given VHL disease family will manifest some or all these tumor types is profoundly influenced by the VHL allele it carries. For example, almost all VHL disease families that develop paraganglioma have missense VHL mutations. VHL families with null VHL alleles develop kidney cancer and hemangiobla...
• Paracrine FGF1 directs architecture and size AI翻译
  作者：Khetchoumian, Konstantin; Sochodolsky, Kevin; Lafont, Chrystel; Gouhier, Arthur; Bemmo, Amandine; Kherdjemil, Yacine; Kmita, Marie; Le Tissier, Paul; Mollard, Patrice; Christian, Helen; Drouin, Jacques
  作者单位：Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); University of Edinburgh; University of Oxford
  摘要：Organ architecture is established during development through intricate cell-cell communication mechanisms, yet the specific signals mediating these communications often remain elusive. Here, we used the anterior pituitary gland that harbors different interdigitated hormone- secreting homotypic cell networks to dissect cell-cell communication mechanisms operating during late development. We show that blocking differentiation of corticotrope cells leads to pituitary hypoplasia with a major effec...
• Subcellular activation of β- adrenergic receptors using a spatially restricted antagonist AI翻译
  作者：Liccardo, Federica; Morstein, Johannes; Lin, Ting-Yu; Pampel, Julius; Lang, Di; Shokat, Kevan M.; Irannejad, Roshanak
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco
  摘要：Gprotein- coupled receptors (GPCRs) regulate several physiological and pathological processes and represent the target of approximately 30% of Food and Drug Administration- approved drugs. GPCR- mediated signaling was thought to occur exclusively at the plasma membrane. However, recent studies have unveiled their presence and function at subcellular membrane compartments. There is a growing interest in studying compartmentalized signaling of GPCRs. This requires development of tools to separat...
• Akira Endo, who discovered a penicillin for heart attacks (1933 to 2024) AI翻译
  作者：Goldstein, Joseph L.; Brown, Michael S.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center
• Mechanically adaptive and deployable intracortical probes enable long- term neural electrophysiological recordings AI翻译
  作者：Wang, Suhao; Jiang, Qianqian; Liu, Hang; Yu, Chaonan; Li, Pengxian; Pan, Gang; Xu, Kedi; Xiao, Rui; Hao, Yaoyao; Wang, Chengjun; Song, Jizhou
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Flexible intracortical probes offer important opportunities for stable neural interfaces by reducing chronic immune responses, but their advances usually come with challenges of difficult implantation and limited recording span. Here, we reported a mechanically adaptive and deployable intracortical probe, which features a foldable fishbone-like structural design with branching electrodes on a temperature- responsive shape memory polymer (SMP) substrate. Leveraging the temperature- triggered so...